Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)

Han, Kyungdo; Hong, Jihye; Park, Jung Ho; Bae, Ji Hoon; Moon, Young-Wan; Kim, Jae Gyoon

doi:10.1016/j.joca.2015.10.011

Cited by 42 publications

(46 citation statements)

References 46 publications

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“…Yet another cross‐sectional study found increasing odds of knee OA with increasing quartiles of BMI and fat mass, but no association was found with lower extremity muscle mass . In the same study, obese subjects with a low percentage of lower extremity muscle mass (comparable to sarcopenic obese subjects in our study) and nonobese subjects with a low percentage of lower extremity muscle mass (comparable to sarcopenic subjects in our study) were found to have greater odds of radiographic OA compared with nonobese subjects with normal lower extremity muscle mass.…”

Section: Discussionsupporting

confidence: 60%

“…The few previous studies that have examined the association of body composition with knee OA have found conflicting results . Issues with study design and lack of consistency in definition of obesity and sarcopenia from body composition assessment (i.e., fat and muscle mass) partly explain discordant results.…”

Section: Discussionmentioning

confidence: 96%

“…Thus, it is not clear whether the effects of “BMI,” typically interpreted as effects of obesity, are truly due to excess adiposity rather than to overall loading due to the combined weight of body mass. The few studies that have examined body composition in relation to knee OA have mostly been cross‐sectional in design, which limits one's ability to make an inference regarding directionality of the association . To better understand how total body mass as opposed to adiposity leads to knee OA, a longitudinal study of body composition and risk of knee OA is needed.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia

Misra

Fielding

Felson

et al. 2019

Arthritis & Rheumatology

129

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia

Misra

Fielding

Felson

et al. 2019

Arthritis & Rheumatology

129

View full text Add to dashboard Cite

show abstract

“…In the case of KNHANES V 1–2, a total of 6,567 households selected from 384 survey regions responded to the questionnaire-based survey and were categorized by region, gender, age, and average household size. The details of the KNHANES V have been previously described elsewhere [1, 17, 18]. This cross-sectional study used data from the fifth KNHANES V 1–2 (N = 17,476; performed from January 2010 to December 2011).…”

Section: Methodsmentioning

confidence: 99%

Relationship between decreased lower extremity muscle mass and knee pain severity in both the general population and patients with knee osteoarthritis: Findings from the KNHANES V 1-2

et al. 2017

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ObjectiveTo identify the prevalence of and risk factors for knee pain and radiographic knee osteoarthritis (RKOA) and to investigate the relationship between decreased lower extremity muscle mass (DLEM) and knee pain severity.MethodsUsing data from the Korea National Health and Nutrition Examination Survey, 3,278 participants who were ≥50 years old and who underwent dual x-ray absorptiometry, plain knee radiographs and completed a knee pain questionnaire were enrolled. Lower extremity muscle mass (LEM) was defined as the sum of the fat-free soft tissue mass of the legs, and lower extremity muscle mass index (LMI) was calculated as LEM/body weight (%). DLEM was defined as an LMI more than two standard deviations below the mean of a gender-matched young reference group. Categorical variables were presented as numbers (weighted %).ResultsThe prevalence of knee pain and RKOA were 22% (n = 721) and 34.7% (n = 1,234), respectively. Multivariate logistic regression analysis showed being female (OR 2.15, 95% CI 1.67–2.79), older (OR 1.03, 95% CI 1.01–1.04), less educated (OR 1.72, 95% CI 1.09–2.71), stiffness (OR 16.15, 95% CI 12.04–21.66), bed rest (OR 2.49, 95% CI 1.81–3.43), RKOA (OR 2.20, 95% CI 1.78–2.74) and DLEM (OR 1.54, 95% CI 1.09–2.17) were associated with knee pain. Participants with simultaneous RKOA and DLEM complained of more severe pain (pain score 7.18 ± 2.48) than those with knee pain without RKOA or DLEM (5.02 ± 2.44), those with only RKOA (6.29 ± 2.50), or those with only DLEM (6.78 ± 2.18) (P<0.001). These results remained after multivariate analyses of variance (MANOVAs).ConclusionThe prevalence of knee pain and RKOA were 22% and 34.7%, respectively, in the general Korean population. DLEM was an independent risk factor for knee pain and it was associated with increased pain severity, regardless of RKOA.

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“…Obesity influences OA not only by increasing weight loads on the knee joints, but also by adipose tissue working as a source of inflammation . Body composition represented as fat mass, rather than body weight, is more important and closely related to knee OA . Adipose tissue releases adipokines, which enhance catabolic factors and lead to the synovial inflammation and structural damage of OA …”

Section: Discussionmentioning

confidence: 99%

Association of periodontitis with radiographic knee osteoarthritis

Kim

Chung

Lee

et al. 2019

Journal of Periodontology

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Background To examine whether periodontitis is associated with the presence and severity of radiographic knee osteoarthritis (OA). Methods Using data from the Korea National Health and Nutrition Examination Survey between 2010 and 2013, participants over the age of 50 were included in this study. Dental examinations and knee radiographs are performed in participants aged ≥50 years in this cohort. Periodontitis was defined using the community periodontal index, which was determined by measuring periodontal probing depth. The definition of radiographic knee OA was based on the Kellgren‐Lawrence (K‐L) grading system, which determined a K‐L class ≥2 to be radiographic knee OA. The associations between periodontitis and presence and severity of radiographic knee OA were examined using logistic regression analyses. Results Among 7969 total participants, 965 men and 2078 women had radiographic knee OA. Periodontitis was observed in 1,185 (39.4%) people among those who had radiographic knee OA. Periodontitis (adjusted odds radio [aOR] 1.21, 95% confidence interval 1.05 to 1.40) was associated with radiographic knee OA after adjusting for variables including age, sex, body mass index, socioeconomic status, diabetes, and dental status. Participants were more likely to have radiographic knee OA as the severity of periodontitis increased (non‐severe periodontitis, aOR 1.14 [0.98 to 1.32]; severe periodontitis, aOR 1.47 [1.17 to 1.85]). Moreover, the presence of periodontitis significantly increased with an increasing K‐L class (class 1, aOR 1.30 [1.09 to 1.54]; class 2, aOR 1.32 [1.08 to 1.60]; class 3, aOR 1.39 [1.14 to 1.70]; class 4, aOR 1.45 [1.11 to 1.90]). Conclusion Periodontitis is associated with the presence and severity of radiographic knee OA.

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Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)

Abstract: In women, high fat mass and low lower extremity muscle mass were associated with presence and severity of knee OA. Lower extremity muscle mass was more closely correlated with knee OA than obesity in women.

Cited by 42 publications

References 46 publications

Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia

Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia

Relationship between decreased lower extremity muscle mass and knee pain severity in both the general population and patients with knee osteoarthritis: Findings from the KNHANES V 1-2

Association of periodontitis with radiographic knee osteoarthritis

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