Beam distribution homogenization design for laser-driven proton therapy accelerator

Wang, Kedong; Easton, Matthew; Li, Y.J.; Wang, K.; Xie, X. C.; Lan, Haiping; Cai, Siyuan; Wang, H.; Ge, Huilin; Zhu, Tingru; Li, J.; Zhang, C.J.; Zhao, Xiaozhen; Lin, Chen; Yan, Xueqing

doi:10.1016/j.nima.2022.167196

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…Therefore, each term of the x and y expansions above represents the formula for the magnetic field strength of the 2n pole, respectively. When n = 4 and n = 6, the magnetic field formula of the normalized positive octupole-pole field and dodecapole-pole field is [21,22] listed in Table 1:…”

Section: Multipole Magnetmentioning

confidence: 99%

“…Firstly, to minimize beam coupling in the horizontal and vertical directions, the beam cross-section at the nonlinear magnet should be "flattened". This means that the horizontal size-to-vertical size ratio of the beam should be greater than 4 [21]. This ensures that coupling effects between the two directions do not adversely affect uniformization.…”

Section: The Physical Principle Of Beam Uniformization Using Nonlinea...mentioning

confidence: 99%

“…Jing-yu Tang proposed a step-like field magnet (SFM) and studied its uniformization effect [19]. Both domestically and internationally, schemes for beam transport uniformization include nonlinear magnets with two pairs of octupole magnets and twelve-pole magnets in the ESS long-pulse target transport line [20], and two pairs of octupole nonlinear magnets in the CLAPA-II laser accelerator at Peking University [21]. A step-like magnet was designed for the IFIF-HEBT transport lines [20].…”

Section: Introductionmentioning

confidence: 99%

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Investigation into the Uniformization of Proton Beams for FLASH Therapy

Han,

Zhang

2024

Applied Sciences

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FLASH proton therapy is widely considered in many labs. However, achieving a dose rate sufficient for FLASH is challenging, especially when using the scanning method. A beam uniformization process using a nonlinear magnet is employed to reduce the scanning time, supplemented by multi-energy extraction to enhance the dose rate. The impact of octupole fields, multipole field components, and step field on the transport line are tested. The nonlinear effect of the magnetic fields on the transverse motion of the particle beam is used to establish a uniform dose distribution at the target. Different schemes are investigated and the octupole approach was finally selected.

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Section: Multipole Magnetmentioning

confidence: 99%

Section: The Physical Principle Of Beam Uniformization Using Nonlinea...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation into the Uniformization of Proton Beams for FLASH Therapy

Han,

Zhang

2024

Applied Sciences

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A design of debris mitigation system for high-repetition-rate petawatt laser experiments

Chen,

Zhao,

et al. 2024

Nuclear Instruments and Methods in Physics Research Section A:

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Human radiological safety assessment for petawatt laser-driven ion acceleration experiments in CLAPA-T

Zhang,

Zhao,

et al. 2024

Matter and Radiation at Extremes

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The newly built Compact Laser Plasma Accelerator–Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs duration. Driven by this petawatt laser facility, proton beams with energy up to 200 MeV are expected to be generated for tumor therapy. During high-repetition operation, both prompt radiation and residual radiation may cause safety problems. Therefore, human radiological safety assessment before commissioning is essential. In this paper, we simulate both prompt and residual radiation using the Geant4 and FLUKA Monte Carlo codes with reasonable proton and as-produced electron beam parameters. We find that the prompt radiation can be shielded well by the concrete wall of the experimental hall, but the risk from residual radiation is nonnegligible and necessitates adequate radiation cooling. On the basis of the simulation results, we discuss the constraints imposed by radiation safety considerations on the annual working time, and we propose radiation cooling strategies for different shooting modes.

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Beam distribution homogenization design for laser-driven proton therapy accelerator

Cited by 7 publications

References 30 publications

Investigation into the Uniformization of Proton Beams for FLASH Therapy

Investigation into the Uniformization of Proton Beams for FLASH Therapy

A design of debris mitigation system for high-repetition-rate petawatt laser experiments

Human radiological safety assessment for petawatt laser-driven ion acceleration experiments in CLAPA-T

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