BDNF Val66Met polymorphism and goal-directed behavior in healthy elderly — evidence from auditory distraction

Getzmann, Stephan; Gajewski, Patrick D.; Hengstler, Jan G.; Falkenstein, Michael; Beste, Christian

doi:10.1016/j.neuroimage.2012.08.079

Cited by 48 publications

(32 citation statements)

References 74 publications

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“…Similar to some previous reports (Barton et al, 2014; Erickson et al, 2008; Gajewski et al, 2011; Getzmann et al, 2013), we found paradoxical results for the BDNF met allele in relation to behavior. That is, we found that BDNF met homozygotes performed superior to the val allele carriers in the sequence learning task.…”

Section: Resultssupporting

confidence: 87%

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

et al. 2016

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The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults’ performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals’ motor learning and performance were associated with their age and genotypes. We selected three genetic polymorphisms: Catechol-O-Methyl Transferase (COMT val158met) and Dopamine D2 Receptor (DRD2 G > T), which are involved with dopaminergic regulation, and Brain Derived Neurotrophic Factor (BDNF val66met) that modulates neuroplasticity and has been shown to interact with dopaminergic genes. Although the underlying mechanisms of the function of these three genotypes are different, the high performance alleles of each have been linked to better learning and performance. We created a composite polygene score based on the Number of High Performance Alleles (NHPA) that each individual carried. We found several associations between genetic profile, motor performance, and sensorimotor adaptation. More importantly, we found that this association varies with age, task type, and engagement of implicit versus explicit learning processes.

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Section: Resultssupporting

confidence: 87%

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

et al. 2016

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“…Unfortunately, studies with healthy elderly subjects represent a challenge in this field. Finally, it is already known that the BDNF Val66Met polymorphism has effects on other cognitive domains besides memory, including distinct components of executive functions, 35,38 reasoning, 16 attention, 39 and visualauditory working memory. 40 Therefore, we were not able to restrict the effects of this SNP to memory.…”

Section: Discussionmentioning

confidence: 99%

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

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Levandowski

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged 4 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.

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“…A strength of this cross-sectional design, however is the sampling from the whole adult lifespan, rather than using the more common, but limited extreme age group comparison approach, which cannot explore age trajectories across the lifespan, nor can examine linear age x genotype interactions. Second, several studies have found that BDNF val66met polymorphism also exerts effects on domains of cognition besides memory: reasoning (Harris et al, 2006), executive functions (Erikson et al, 2008), task-switching (Gajewski et al, 2011), attention (Getzmann et al, 2013), and processing speed (Ghisletta et al, 2014; Raz et al, 2009). Thus, the effect of BDNF is likely not selective to memory, per se , but impacts other cognitive processes, that may in turn relate to memory processes.…”

Section: Discussionmentioning

confidence: 99%

BDNF val66met polymorphism affects aging of multiple types of memory

et al. 2015

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The BDNF val66met polymorphism (rs6265) influences activity-dependent secretion of brain-derived neurotrophic factor in the synapse, which is crucial for learning and memory. Individuals homozygous or heterozygous for the met allele have lower BDNF secretion than val homozygotes and may be at risk for reduced declarative memory performance, but it remains unclear which types of declarative memory may be affected and how aging of memory across the lifespan is impacted by the BDNF val66met polymorphism. This cross-sectional study investigated the effects of BDNF polymorphism on multiple indices of memory (item, associative, prospective, subjective complaints) in a lifespan sample of 116 healthy adults aged 20-93 years. Advancing age showed a negative effect on item, associative and prospective memory, but not on subjective memory complaints. For item and prospective memory, there were significant age x BDNF group interactions, indicating the adverse effect of age on memory performance across the lifespan was much stronger in the BDNF met carriers than for the val homozygotes. BDNF met carriers also endorsed significantly greater subjective memory complaints, regardless of age, and showed a trend (p < .07) toward poorer associative memory performance compared to val homozygotes. These results suggest that genetic predisposition to the availability of brain-derived neurotrophic factor, by way of the BDNF val66met polymorphism, exerts an influence on multiple indices of episodic memory – in some cases in all individuals regardless of age (subjective memory and perhaps associative memory), in others as an exacerbation of age-related differences in memory across the lifespan (item and prospective memory).

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BDNF Val66Met polymorphism and goal-directed behavior in healthy elderly — evidence from auditory distraction

Cited by 48 publications

References 74 publications

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

BDNF val66met polymorphism affects aging of multiple types of memory

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