BDNF expression in olfactory bulb and epithelium during regeneration of olfactory epithelium

Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis

“…Moreover, during forced OE regeneration, there is also gene expression of BDNF in the OE and OB. These results are not in accordance with the hypothesis that in normal OE, BDNF protein is only produced in OB and then retrogradely transported to ORN through their axons, in order to promote the maturation of newly generated neurons (Feron et al, 2008;Uranagase et al, 2012).…”

“…This does not preclude that BDNF acts on neuronal homeostasis: as it has recently been shown that BDNF synthetized in hippocampal astrocytes acts in a paracrine manner on the adjacent neurons (Quesseveur et al, 2013). Together, these results support the idea that OB could supply at least a part of the BDNF protein to the OE through ORN axonal transportation during an OE regeneration promoting the massive differentiation and maturation of ORNs due to the loss of SUS cells (Uranagase et al, 2012). These results are not in accordance with previous reports showing BDNF in olfactory neurons in mice under physiological conditions (Clevenger et al, 2008;Takami et al, 2005).…”

“…Neural stem cells expansion and differentiation involve stages of proliferation and maturation governed by the sequential and combinatorial exposure of cells to extrinsic factors (Simpson et al, 2007). To date, numerous growth factors have been reported to play critical roles in progenitor cell proliferation, neurogenesis, lineage determination, and maintenance of neurons in the olfactory system (Adachi et al, 2005;Calof et al, 1998;Cao et al, 2007;Clevenger et al, 2008;Feron et al, 2008;Newman et al, 2000;Uranagase et al, 2012;Yasuno et al, 2000).…”

“…2008). In addition, several studies have documented that the neurotrophins NGF and BDNF sequentially promote proliferation of the developing olfactory neuronal precursors (Clevenger et al, 2008;Newman et al, 2000;Uranagase et al, 2012). Both NGF and BDNF increase the expression of cyclin D1 and cyclin-dependent kinase 4 (cdk4) affecting the proliferation kinetics of the ORN precursors (Simpson et al, 2007).…”

Acute Treatment with T-Type Calcium Channel Enhancer SAK3 Reduces Cognitive Impairments Caused by Methimazole-Induced Hypothyroidism Via Activation of Cholinergic Signaling

“…As MMI treatment decreases OMP levels and then injures systematic spherical structures in the OB [37,38], we performed a morphometric analysis on glomeruli size in MMI-treated mice followed by acute SAK3 administration. A significant group effect was observed in glomeruli size (F [7,40] = 3.642, p = 0.004).…”