BDNF association study with obsessive–compulsive disorder, its clinical characteristics, and response to fluvoxamine-treatment in Iranian patients.

Abstract

Obsessive–compulsive disorder (OCD) is a chronic neuropsychiatric disorder with complex genetic inheritance. Findings suggest a role for brain-derived neurotrophic factor (BDNF) in OCD, but reports are limited. Here we studied the association of BDNF polymorphisms rs6265 and rs2883187 with OCD and its clinical characteristics in Iranian patients as well as the fluvoxamine-treatment outcome of OCD patients. Iranian OCD patients who were diagnosed according to DSM–IV–TR entered the study. DNAs were extracted from blood samples and were genotyped by means of PCR-RFLP. A total of 200 OCD cases and 225 controls for rs6265 and 219 cases and 224 controls for rs2883187 were studied in the genetic association analysis. Pharmacotherapy was defined as 12 weeks treatment with fluvoxamine (daily dose: 150–300 mg), and patients were classified into 3 groups (responders, nonresponders, and refractory) based on the reduction in their Y-BOCS severity scores. Data of 94 patients for rs6265 and 106 patients for rs2883187 was analyzed to evaluate the association of these single nucleotide polymorphism (SNPs) with treatment response. A significant association was detected between the BDNF polymorphism rs2883187 and OCD (p = .00). The other BDNF polymorphism, rs6265, was not associated with OCD, but a weak association with the cleaning-contamination subtype was detected (p = .038). No association was detected between BDNF SNPs and sex, age of onset, and family history. None of the studied BDNF SNPs or their haplotypes were associated with fluvoxamine treatment response. Results propose BDNF SNP, rs2883187, as a candidate genetic factor in OCD but not in OCD treatment response with fluvoxamine.

Impact of brain-derived neurotrophic factor Val66Met polymorphism and response to escitalopram or paroxetine in obsessive–compulsive disorder

“…Pharmacogenetic evaluations of BDNF polymorphisms with treatment response in OCD have been scarce. However, our results, which indicate an absence of overall impact on the efficacy of SSRI treatment are in agreement with those of four previous association studies on BDNF variants among patients with OCD [8][9][10][11] and in a genome-wide association study of treatment response among 804 patients with OCD. 20 Real et al 11 carried out a single-marker and haplotype association study of eight BDNF SNPs on a sample of 123 Spanish Caucasian OCD patients treated with fluoxetine, fluvoxamine, or clomipramine for 12 weeks.…”

“…9 Similarly, among 94 Iranian patients, none of the two BDNF SNPs studied (rs6265, rs2883187) nor their haplotypes were associated with response to fluvoxamine after 12 weeks. 10 The importance of clinical OCD symptom subtypes has been underlined in recent years. Thus, not taking these dimensions into account could be a confounding factor in the interpretation of studies.…”

“…6,7 Few studies are available on response to drug treatment in OCD and no association has been suggested between Val66Met polymorphism and response to antidepressant drugs, whether among Japanese, 8 Southern Indian, 9 or Iranian patients. 10 However, one study reported the involvement of the BDNF gene in the response to antidepressant treatment among Caucasians. 11 Several reasons could explain the negative results found for the association between Val66Met polymorphism and the efficacy of antidepressant drugs.…”

Symptom Dimensions and Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Obsessive-compulsive Disorder

“…In line with few studies in Iran, e.g. a study by Abdol-Hosseinzadeh et al [44], the present study aimed to investigate the role of Val-66Met polymorphism in BDNF gene in OCD among the Iranian population.…”

The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap

“…A recent meta-analysis found that brain-derived neurotrophic factor (BDNF) is significantly reduced in individuals with OCD (Suliman et al, 2013). A significant association was detected between BDNF polymorphism rs2883187 and OCD (Abdolhosseinzadeh et al, 2019), and Hall et al (2003) showed a strong association between BDNF gene sequence variants, including the Val66Met variation, and OCD. Subsequent studies also showed that the Val66-Met BDNF gene variant is a risk allele for development of OCD, possibly in a sex-specific manner (Hemmings et al, 2008;Katerberg et al, 2009).…”