BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat

Li, Xiangyang; Liu, Jianhui; Zhou, Guang‐Peng; Sang, Yujian; Zhang, Yue; Li, Jing; Shi, Zhixiong; Zhou, Xianqing; Sun, Zhiwei

doi:10.1016/j.envint.2020.106307

Cited by 63 publications

(30 citation statements)

References 51 publications

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“…Considering that reproductive toxicity of DBDPE has been recently reported in rats, , we were also interested in further evidence for reproductive toxicity in zebrafish. Therefore, we constructed a hypothetical network based on the DEPs involved in muscle contraction and the estrogen response for predicting the possible toxic mechanism of DBDPE.…”

Section: Discussionmentioning

confidence: 99%

“…14 Environmental toxicologists have recently proved that DBDPE could induce hepatotoxicity, 15 cardiotoxicity, 16 and reproductive toxicity in rat. 17,18 Although DBDPE has a similar structure to BDE209, our recent study showed that it may have different effects on the thyroid system in zebrafish larvae compared with BDE209. 19 Many studies have indicated that targeted accumulation in specific tissues can pose direct exposure and cause consequent toxicity.…”

Section: Introductionmentioning

confidence: 98%

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Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish

Sun

Zhu

Ling

et al. 2021

Environ. Sci. Technol.

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The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a widespread environmental pollutant. However, the target tissue and toxicity of DBDPE are still not clear. In the current study, female zebrafish were exposed to 1 and 100 nM DBDPE for 28 days. Chemical analysis revealed that DBDPE tended to accumulate in the brain other than the liver and gonad. Subsequently, tandem mass tag-based quantitative proteomics and parallel reaction monitoring verification were performed to screen the differentially expressed proteins in the brain. Bioinformatics analysis revealed that DBDPE mainly affected the biological process related to muscle contraction and estrogenic response. Therefore, the neurotoxicity and reproductive disruptions were validated via multilevel toxicological endpoints. Specifically, locomotor behavioral changes proved the potency of neurotoxicity, which may be caused by disturbance of muscular proteins and calcium homeostasis; decreases of sex hormone levels and transcriptional changes of genes related to the hypothalamic-pituitary-gonad-liver axis confirmed reproductive disruptions upon DBDPE exposure. In summary, our results suggested that DBDPE primarily accumulated in the brain and evoked neurotoxicity and reproductive disruptions in female zebrafish. These findings can provide important clues for a further mechanism study and risk assessment of DBDPE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish

Sun

Zhu

Ling

et al. 2021

Environ. Sci. Technol.

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“…To date, Li et al, have reported the male reproductive toxicity of DBDPE, they found that DBDPE exposure resulted in damage to the testicular structure and a significant decrease in sperm motility and quantity. 30 Moreover, our previous researches have described that DBDPE exposure induced FMN2-mediated F-actin polymerization to decrease by inhibiting the inactivation of CDK1, resulting in failure of spindle migration and membrane protrusions required for extremely asymmetric division in anaphase I oocytes. 31 In addition, DBDPE exposure in vitro inhibits the excretion of the first polar body of oocyte.…”

Section: Introductionmentioning

confidence: 99%

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F‐actin in zygotes and leads to cognitive and social disorders in offspring mice

Shi

Zhang

et al. 2022

The FASEB Journal

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Decabromodiphenyl ethane (DBDPE) is a novel retardant. DBDPE is used in various flammable consumer products such as electronics, building materials, textiles, and children's toys. The presence of DBDPE in humans makes it extremely urgent to assess the health effects of DBDPE exposure. Here, we used female mice as an animal model to investigate the effects of DBDPE on embryonic development and offspring health. The results showed that 50 μg/kg bw/day of DBDPE exposure did not affect spindle rotation in oocytes after fertilization, but led to a decrease of pronuclei (PN) in zygotes. Further investigation found that DBDPE interferes with the self‐assembly of F‐actin in PN, resulting in PN reduction, DNA damage, and reduced expression of zygotic genome activating genes, and finally leading to abnormal embryonic development. More importantly, we found that maternal DBDPE exposure did not affect the growth and development of the first generation of offspring (F1) mice, but resulted in behavioral defects in F1 mice. Female F1 mice from DBDPE‐exposed mothers exhibited increased motor activity and deficits in social behavior. Both female and male F1 mice from DBDPE‐exposed mothers exhibited cognitive memory impairment. These results suggest that DBDPE has developmental toxicity on embryos and has a cross‐generational interference effect. It is suggested that people should pay attention to the reproductive toxicity of DBDPE. In addition, it also provides a reference for studying the origin of neurological diseases and indicates that adult diseases caused by environmental pollutants may have begun in the embryonic stage.

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“…Assessment of Oxidative Stress Level in the Hippocampus. Similar to the method using kits conducted by Li et al (2021), 18 ROS, MDA, and GSH were detected to assess the oxidative stress level of hippocampus in mice. The hippocampal tissues were homogenized (1:10, w/v) with PBS (pH 7.2−7.4).…”

Section: ■ Introductionmentioning

confidence: 99%

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

Wang

Dai

2022

Chem. Res. Toxicol.

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Brominated flame retardants (BFRs) are ubiquitous industrial chemicals. In China, BFRs that are applied in large quantities include decabromodiphenyl ether (BDE-209), tetrabromobisphenol A (TBBPA), and hexabromocyclododecane (HBCD). Although findings are not always unequivocal, mounting evidence in vivo suggests that the BFRs have potential neurotoxicity. The present study aimed to assess and compare the neurotoxic effects of these three BFRs’ exposure. Male mice were orally exposed to BDE-209, TBBPA, or HBCD at 50 and 100 mg/kg bw/day for 28 days. The cognitive behavior, oxidative stress (ROS, MDA, and GSH), apoptosis-related genes (caspase-3, bax, and bcl-2), memory-related proteins (BDNF and PSD-95), and neurotransmitters (AChE and ChAT) were detected comparatively. Results showed that high doses of BDE-209, TBBPA, and HBCD exposure impaired spatial memory of mice, elevated ROS and MDA and reduced GSH levels of hippocampus, upregulated caspase-3 and bax expressions, decreased BDNF and PSD-95 levels, and disordered AChE and ChAT levels. Notably, BDE-209 caused greater adverse effects > HBCD > TBBPA. This study confirms and extends that these three BFRs had similar neurotoxic effects at current concentrations, although they may be more or less toxic.

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BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat

Cited by 63 publications

References 51 publications

Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish

Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F‐actin in zygotes and leads to cognitive and social disorders in offspring mice

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

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