BCG infection in mice is promoted by naïve mesenchymal stromal cells (MSC) and suppressed by poly(A:U)-conditioned MSC

Schwartz, Y. Sh.; Белогородцев, С. Н.; Филимонов, П. Н.; Чередниченко, А Г; Pustylnikov, Sergei; Краснов, В. А.

doi:10.1016/j.tube.2016.09.005

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…In a study published by Schwartz et al, they demonstrated that MSC treatment in mice infected with Mycobacterium bovis promoted bacterial growth in the spleen. Suppression of bacterial growth was only achieved after the MSCs were preconditioned with TLR-3 ligand 82 . This data is telling, but not entirely unexpected, as MSCs are actively involved in immunomodulation.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure

2020

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The emergence of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) at the end of 2019 in Hubei province China, is now the cause of a global pandemic present in over 150 countries. COVID-19 is a respiratory illness with most subjects presenting with fever, cough and shortness of breath. In a subset of patients, COVID-19 progresses to hypoxic respiratory failure and acute respiratory distress syndrome (ARDS), both of which are mediated by widespread inflammation and a dysregulated immune response. Mesenchymal stem cells (MSCs), multipotent stromal cells that mediate immunomodulation and regeneration, could be of potential benefit to a subset of COVID-19 subjects with acute respiratory failure. In this review, we discuss key features of the current COVID-19 outbreak, and the rationale for MSC-based therapy in this setting, as well as the limitations associated with this therapeutic approach.

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Section: Antimicrobial Propertiesmentioning

confidence: 99%

Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure

2020

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“…Further, injection of BM-MSCs in Paracoccidioides brasiliensis -infected mice led to increased fungal levels and exaggerated immune responses, with increased accumulation of neutrophils, eosinophils, and M2 macrophages, leading to congestion and edema in lungs[ 84 ]. Similarly, treatment with BM-MSCs in mice with latent M. bovis infection resulted in significantly higher mycobacterial number and granuloma formation[ 85 ]. However, if the MSCs were conditioned with TLR-3 ligand, poly (A:U) prior to the injection, it significantly reduced the pathogen load, suggesting that priming of MSCs was necessary for their anti-mycobacterial effect[ 85 ].…”

Section: Mscs In Immunomodulationmentioning

confidence: 99%

“…Similarly, treatment with BM-MSCs in mice with latent M. bovis infection resulted in significantly higher mycobacterial number and granuloma formation[ 85 ]. However, if the MSCs were conditioned with TLR-3 ligand, poly (A:U) prior to the injection, it significantly reduced the pathogen load, suggesting that priming of MSCs was necessary for their anti-mycobacterial effect[ 85 ].…”

Section: Mscs In Immunomodulationmentioning

confidence: 99%

“…Exposure to IFN-γ or TLR3 ligand poly (I:C) increased HLA-I expression in MSCs, which protected the cells from killing by NK cells[ 56 , 178 ]. Furthermore, murine BM-MSCs pre-conditioned with TLR3 ligand poly (A:U) were more efficient than naïve MSCs in eliminating M. bovis in an experimental model[ 85 ]. TLR4 activation in LPS-stimulated MSCs expedited wound healing by promoting neutrophil migration and NETosis at the site of infection[ 79 ].…”

Section: Genetic Modifications and Priming Of Mscsmentioning

confidence: 99%

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Review of the potential of mesenchymal stem cells for the treatment of infectious diseases

Sharma¹,

Chakraborty²,

Jaganathan³

2021

WJSC

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The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen load and tissue damage encountered during infectious diseases through the secretion of antimicrobial factors for pathogen clearance and they phagocytose certain bacteria themselves. MSCs dampen tissue damage during infection by downregulating the levels of pro-inflammatory cytokines, and inhibiting the excessive recruitment of neutrophils and proliferation of T cells at the site of injury. MSCs aid in the regeneration of damaged tissue by differentiating into the damaged cell types or by releasing paracrine factors that direct tissue regeneration, differentiation, and wound healing. In this review, we discuss in detail the various mechanisms by which MSCs help combat pathogens, tissue damage associated with infectious diseases, and challenges in utilizing MSCs for therapy.

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“…Besides, studies have shown that MSCs do regulate the growth of Mtb. Schwartz et al found that MSCs could promote the growth of Mtb in splenic granuloma, while MSCs treated with Poly (A: U) could inhibit the growth of Mtb in splenic granuloma (24). In addition, MSCs display a novel phagocytom-like function and restrict Mtb growth via scavenger receptors (SR)mediated internalize or phagocytosis and autophagy during TB infection (25).…”

Section: Mscs and Tg Mscs Regulates Mtb Growthmentioning

confidence: 99%

Mesenchymal Stem Cells and Tuberculosis: Clinical Challenges and Opportunities

Zhang

Xie

et al. 2021

Front. Immunol.

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Tuberculosis (TB) is one of the communicable diseases caused by Mycobacterium tuberculosis (Mtb) infection, affecting nearly one-third of the world’s population. However, because the pathogenesis of TB is still not fully understood and the development of anti-TB drug is slow, TB remains a global public health problem. In recent years, with the gradual discovery and confirmation of the immunomodulatory properties of mesenchymal stem cells (MSCs), more and more studies, including our team’s research, have shown that MSCs seem to be closely related to the growth status of Mtb and the occurrence and development of TB, which is expected to bring new hope for the clinical treatment of TB. This article reviews the relationship between MSCs and the occurrence and development of TB and the potential application of MSCs in the treatment of TB.

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BCG infection in mice is promoted by naïve mesenchymal stromal cells (MSC) and suppressed by poly(A:U)-conditioned MSC

Cited by 10 publications

References 33 publications

Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure

Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure

Review of the potential of mesenchymal stem cells for the treatment of infectious diseases

Mesenchymal Stem Cells and Tuberculosis: Clinical Challenges and Opportunities

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