Bazı Geofit Türlerin Biyoaktif Bileşiklerinin Tuzlu Su Karidesi (Artemia salina)'ne Karşı Toksisite Aktivitesinin Değerlendirilmesi

Abstract

Artemia salina L.is an important model organism for the world ecosystem, which is very sensitive, easily available, allows to work in the laboratory environment, is used in toxic effect studies, and gives safe results. This study was designed to evaluate the toxic effect of water extract of fresh and underground parts of some species of five geophyte genera (Arum rupicola var. virescens (Stapf) P.C. Boyce, Cyclamen cilicium Boiss. & Heldr, Gagea bohemica (Zauschn.) Schult. & Schult. f., Narcissus tazetta subsp. tazetta L., Paeonia kesrouanensis J. Thiébaut) against A. salina. All taxa were found to be more toxic in the fresh part than in the underground part. The fresh part of P. kesrouanensis was shown the highest toxic effect with 44.44 ± 2.78% (1.56 ± 0.13 mg/mL, LC 50 ) and the underground part of N. tazetta subsp. tazetta was shown the lowest toxic effect with 8.33 ± 0.00% (294.68 ± 1.54 mg/mL, LC 50 ). The underground part of N. tazetta subsp. tazetta and Gagea bohemica were not found toxic with > 1000 mg/ml, LC 90 . Based on the studies showing that A. salina toxic effect studies are related to insecticide and anticancer studies, it is seen that especially the fresh part of P. kesrouanensis has potential insecticide and anticancer properties, but more studies are needed.