The resurging interest in Byzantine fault tolerant systems will demand more scalable threshold cryptosystems. Unfortunately, current systems scale poorly, requiring time quadratic in the number of participants. In this paper, we present techniques that help scale threshold signature schemes (TSS), verifiable secret sharing (VSS) and distributed key generation (DKG) protocols to hundreds of thousands of participants and beyond. First, we use efficient algorithms for evaluating polynomials at multiple points to speed up computing Lagrange coefficients when aggregating threshold signatures. As a result, we can aggregate a 130,000 out of 260,000 BLS threshold signature in just 6 seconds (down from 30 minutes). Second, we show how "authenticating" such multipoint evaluations can speed up proving polynomial evaluations, a key step in communicationefficient VSS and DKG protocols. As a result, we reduce the asymptotic (and concrete) computational complexity of VSS and DKG protocols from quadratic time to quasilinear time, at a small increase in communication complexity. For example, using our DKG protocol, we can securely generate a key for the BLS scheme above in 2.3 hours (down from 8 days). Our techniques improve performance for thresholds as small as 255 and generalize to any Lagrange-based threshold scheme, not just threshold signatures. Our work has certain limitations: we require a trusted setup, we focus on synchronous VSS and DKG protocols and we do not address the worst-case complaint overhead in DKGs. Nonetheless, we hope it will spark new interest in designing large-scale distributed systems.