Batch crystallization and solid-liquid separation of potassium sulphate

Effects of operating conditions on agglomeration and habit of paracetamol crystals in anti-solvent crystallization

“…Literatures on agglomeration study conducted in a semi-batch manner are relatively scarce in comparison with the above two operation modes. Jones et al [14] used acetone to precipitate potassium sulfate from aqueous solution. Their main finding was that slight dilution of antisolvent greatly improved the permeability of crystal cake by reducing excessive nucleation in the local regions of anti-solvent injection point.…”

Antisolvent membrane crystallization of pharmaceutical compounds

“…The most important properties for a crystalline product are crystal size and size distribution (CSD)—which should be as narrow as possible—shape, habit, polymorphism, and purity. Crystal morphology and structure can impact, for example, dissolution rate and bioavailability7, 8 as well as manufacture operations such as filtration,9, 10 drying, and final product formulation 11. Crystal properties are determined from a variety of factors such as crystallization technique employed, type and size of equipment used, and operating conditions.…”

Particle formation during agglomerative precipitation processes

“…In an effort to control this behaviour, however, Jones et ale (1986) and Jones and Mydlarz (1989) demonstrated the effect of solvent dilution (i.e. Frequently, crystals from a precipitation are small and difficult to separate from their mother liquor, and this is made worse if poor mixing results in high local levels of supersaturation.…”