Antisolvent membrane crystallization of pharmaceutical compounds

Profio, Gianluca Di; Stabile, Carmen; Caridi, Antonella; Curcio, Efrem; Drioli, Enrico

doi:10.1002/jps.21785

Cited by 62 publications

(49 citation statements)

References 33 publications

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“…Our approach can open the avenue to develop robust nanofiltration membranes, having a sharp selectivity in the sub-nanometer range, in addition to another interesting approach using postpore functionalization, recently demonstrated by Zhang et al [29] On the other hand, isoporous hydrophobic block copolymer membranes have been rarely reported before and therefore new applications can profit from this class of membranes. The hydrophobicity of the unmodified membranes as well as the high porosity and well-defined nanochannels can be promising for applications such as membrane distillation, [30] membrane crystallization, [31] and thermo-osmotic energy conversion. [32] Finally, it is worth to mention that PS-b-PB-b-PS terpolymers with other block ratios have been produced as bulk commodity with lower price compared to other block copolymers for mass industrial application.…”

Section: Membrane Modificationmentioning

confidence: 99%

Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Sutisna

Polymeropoulos

Musteata

et al. 2017

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Membranes are prepared by self-assembly and casting of 5 and 13 wt% poly(styrene-b-butadiene-b-styrene) (PS-b-PB-b-PS) copolymers solutions in different solvents, followed by immersion in water or ethanol. By controlling the solution-casting gap, porous films of 50 and 1 µm thickness are obtained. A gradient of increasing pore size is generated as the distance from the surface increased. An ordered porous surface layer with continuous nanochannels can be observed. Its formation is investigated, by using time-resolved grazing incident small angle X-ray scattering, electron microscopy, and rheology, suggesting a strong effect of the air-solution interface on the morphology formation. The thin PS-b-PB-b-PS ordered films are modified, by promoting the photolytic addition of thioglycolic acid to the polybutadiene groups, adding chemical functionality and specific transport characteristics on the preformed nanochannels, without sacrificing the membrane morphology. Photomodification increases fivefold the water permeance to around 2 L m h bar , compared to that of the unmodified one. A rejection of 74% is measured for methyl orange in water. The membranes fabrication with tailored nanochannels and chemical functionalities can be demonstrated using relatively lower cost block copolymers. Casting on porous polyacrylonitrile supports makes the membranes even more scalable and competitive in large scale.

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Section: Membrane Modificationmentioning

confidence: 99%

Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Sutisna

Polymeropoulos

Musteata

et al. 2017

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“…Crystallization of ionic salts [18][19][20], metal ions [21], low molecular organic acids [22][23], proteins and pharmaceutical compounds [24][25][26][27][28] are examples of the applicability of this technology. In addition, the main advantages of membrane crystallization have been already demonstrated: 1) it is possible to control the maximum level of supersaturation due to a defined mass transfer through the membrane [29]; 2) the membrane induces heterogeneous nucleation; 3) size, shape and purity of crystals can be controlled; 4) there is a significant reduction of energy consumption compared to conventional crystallization by means of cooling or evaporation [30]; and 5) comparable or slightly higher nucleation rates with respect to batch crystallizers or tubular precipitators have been obtained [24].…”

Section: Introductionmentioning

confidence: 99%

Technical viability and exergy analysis of membrane crystallization: Closing the loop of CO2 sequestration

Luis

Aubel

Bruggen

2013

International Journal of Greenhouse Gas Control

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“…[25][26][27] In a different approach, the extension of the MCr concept to antisolvent operation, where a porous membrane is used to dose the amount of antisolvent in the crystallizing solution, has been explored. 28 Here, solvent composition within the crystallizing solution is controlled by diffusion in vapor phase, in accordance with the general concept of MCr and dissimilarly from the configuration in which the liquid phase directly permeates through the membrane.…”

Section: Timeline Of the Development Of Membrane-assisted Crystallizamentioning

confidence: 76%

Overview of Membrane-Assisted Crystallization Operations

Drioli¹,

Profio²,

Curcio³

2015

Membrane-Assisted Crystallization Technology

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The interest in combining membrane operations and solution crystallization is motivated by the aim to develop more efficient crystallization processes. Membranes, with their intrinsic characteristics of efficiency and operational simplicity, high selectivity, and permeability for the transport of specific components, compatibility between different membrane operations in integrated systems, low energetic requirement, good stability under operating conditions and environmental compatibility, easy control and scale-up, and large operational flexibility, represent a technology that well satisfies the concept of the rationalization of chemical productions, leading to significant innovation in both processes and products. Accordingly, membrane technology provides significant improvements in crystallization. This approach has been put in practice in a number of membrane-assisted crystallization (MAC) configurations. The main features of MAC are:

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Antisolvent membrane crystallization of pharmaceutical compounds

Cited by 62 publications

References 33 publications

Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Technical viability and exergy analysis of membrane crystallization: Closing the loop of CO2 sequestration

Overview of Membrane-Assisted Crystallization Operations

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