Batch and flow-injection determination of ethylenediamine in pharmaceutical preparations

Milla, M.; Castro, R.; Garcı́a-Vargas, Manuel; Muñoz-Leyva, J.A.

doi:10.1016/s0003-2670(00)84473-6

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1989

2024

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Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Miscellaneous compounds assayed include dyes (II,12), residual solvents (13)(14)(15)(16), simple aldehydes , flavors (112,113), preservatives (114)(115)(116)(117), and plasticizers (118,119).…”

Section: Miscellaneousmentioning

confidence: 99%

Geological and inorganic materials

Jackson¹,

Baedecker²,

Fries³

et al. 1989

Anal. Chem.

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Section: Miscellaneousmentioning

confidence: 99%

Geological and inorganic materials

Jackson¹,

Baedecker²,

Fries³

et al. 1989

Anal. Chem.

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“…[21][22][23][24][25] Diethylenediamine (EDA) is a frequently utilized pharmaceutical excipient and binder. [26,27] It has an LD50 value of 637-1850 mg/ kg when administered orally to rats. [28] This compound is classified as having low toxicity and is readily soluble in water.…”

Section: Introductionmentioning

confidence: 99%

“…However, its poor water solubility interferes with its absorption, resulting in poor bioavailability [21–25] . Diethylenediamine (EDA) is a frequently utilized pharmaceutical excipient and binder [26,27] . It has an LD50 value of 637–1850 mg/kg when administered orally to rats [28] .…”

Section: Introductionmentioning

confidence: 99%

Ethylenediamine Salt Enhances the Solubility and Dissolution of Flurbiprofen

Gao,

Li,

Yan

et al. 2024

ChemistryOpen

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Drugs that are poorly soluble in water are difficult to absorb orally, resulting in low bioavailability. Flurbiprofen (FLU) is an arylpropionic acid nonsteroidal anti‐inflammatory drug belonging to BCS class II, with low water solubility. In this study, a novel flurbiprofen‐ethylenediamine salt (FLU‐EDA) was successfully prepared via solvent crystallization. Its crystal structure was determined via single‐crystal X‐ray diffraction (SXRD). Further, the physicochemical properties of FLU‐EDA salt were characterized by powder X‐ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FT‐IR). The solubility and intrinsic dissolution rate (IDR) of FLU‐EDA salt in water were investigated. The results showed that compared with FLU, the solubility and IDR of FLU‐EDA salt increased by 57‐fold and 32‐fold, respectively. This indicates that FLU‐EDA salt can significantly enhance the solubility and dissolution rate of flurbiprofen in water. This study provides basic data and theory for the development of new formulations of flurbiprofen.

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Flow injection analysis of pharmaceuticals

Castro

Valcárcel

1989

Journal of Pharmaceutical and Biomedical Analysis

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Batch and flow-injection determination of ethylenediamine in pharmaceutical preparations

Cited by 7 publications

References 9 publications

Geological and inorganic materials

Geological and inorganic materials

Ethylenediamine Salt Enhances the Solubility and Dissolution of Flurbiprofen

Flow injection analysis of pharmaceuticals

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