Basosquamous carcinoma: Is it an aggressive tumor?

Abstract

Basosquamous carcinoma is a rare cutaneous tumour that is considered an aggressive type of basal cell carcinoma with an increased risk of recurrence and metastases. This impression has been perpetuated in the literature, despite limited scientific data and conflicting results of some authors. This present study was aimed to evaluate the clinical-pathological features of this tumour and follow-up of a series of basosquamous carcinoma. Basosquamous carcinoma patients who underwent surgical excision between January 2000 and February 2012 were analyzed retrospectively. Their medical files were reviewed and the corresponding routinely stained sections (with hematoxylin-eosin) were re-evaluated by two pathologists. Thirty-five patients with basosquamous carcinoma were operated on in this period. Most tumurs were located in the head and neck area (94%), and the mean age of the patients was 69.8 years. Margin involvements were seen in 11 patients (31.4%) and all of them underwent re-excision. There was only one local recurrence. There was neither regional lymph node nor distant metastasis in this series. The recurrence rate of basosquamous carcinoma is found as 4%, lower than that of most other similar studies. Further pathologic studies are needed to better classify basosquamous carcinoma and to increase consistency between the results of studies. Surgical excision and regular follow-up are considered as the treatment of choice.

Giant basal cell carcinoma associated with vitiligo

“…Metatypical BCC is considered rare, with an approximate incidence of 1.2%‐2.7% among all types of skin cancers . Its occurrence is more frequent in white patients and found more frequently in the head and neck .…”

Basosquamous Carcinoma: Report of Two Cases and Review of Literature

“…Additionally, there is a male predominance and a mean age distribution in the 7 th decade of life [6]. Recurrences occurred mainly in the head and neck area [2].…”

“…BSC is a rare tumor with an incidence of less than 2% of all non-melanoma skin cancers [2] and is predominant in men. Its etiology is multifactorial, but UV radiation, aging, and tobacco exposure seem to play key roles in the onset of BSC [3].…”

“…However, there is a disagreement about aggressiveness of this tumour, and data are insufficient [2].…”

High-risk Cutaneous Squamous Cell Carcinoma

“…24 Specific histopathological subtypes are also identified as high-risk features in NCCN guidelines, including acantholytic, adenosquamous, desmoplastic, and basosquamous subtypes. [25][26][27][28][29][30][31] Invasive Bowen's disease has 10 The presence of one of the above factors signifies high risk; Area H refers to areas at high risk for recurrence, including mask areas of the face (central face, eyelids, eyebrows, periorbital area, nose, lips, chin, ears, genitalia, hands, and feet). Area M refers to middle-risk areas for recurrence, including cheeks, forehead, neck, and scalp.…”