Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory TH17/TH1 response

Chapuy, Laurence; Bsat, Marwa; Mehta, Heena; Rubio, Manuel; Wakahara, Keiko; Van, Vu Quang; Baba, Nobuyasu; Cheong, Cheolho; Yun, Tae Jin; Panzini, Benoît; Wassef, Ramsès; Richard, Carole; Tamaz, Raja; Soucy, Geneviève; Delespesse, Guy; Sarfati, Marika

doi:10.1016/j.jaci.2014.05.025

Cited by 27 publications

(28 citation statements)

References 13 publications

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“…1b), basophils but not mast cells significantly infiltrated the colon of patients with endoscopic active disease when compared to inactive disease (Supporting information, Fig. S3a,d), confirming and extending our previous study [25]. More precisely, frequency of basophils augmented in the colonic mucosa in patients with active B1 when compared to B2 or B3 disease (Supporting information, Fig.…”

Section: The Frequency Of Colonic Neutrophils Correlates With Ses-cdsupporting

confidence: 88%

Recruitment of activated neutrophils correlates with disease severity in adult Crohn’s disease

Therrien

Chapuy

Bsat

et al. 2018

Clinical and Experimental Immunology

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Summary Neutrophils are detected in inflamed colon in Crohn’s disease (CD). However, whether the frequency and/or activation of circulating or gut tissue neutrophils correlate with endoscopic severity remains to be investigated. A cohort of 73 CD patients was prospectively enrolled according to endoscopic severity and treatment history. Individuals with active disease were stratified using the Montreal classification. Harvey–Bradshaw Index (HBI) and Simple Endoscopic Score for Crohn’s Disease (SES‐CD) were performed at the time of ileocolonoscopy. Frequency of neutrophils and their expression of CD66b and CD64 were assessed in paired blood and colonic biopsies using flow cytometry. The percentage of neutrophils increased in inflamed colon and correlated with SES‐CD in the entire cohort of patients examined, as well as in the subgroup with inflammatory (B1) active disease. SES‐CD further correlated with neutrophil CD66b expression in mucosa but not blood and, conversely, with neutrophil CD64 expression in blood but not mucosa. However, the evaluation of neutrophil activation in mucosa when compared to blood reflected disease activity more clearly. Finally, a neutrophil activation power index (CD66b in mucosa X CD64 in blood) that correlated with SES‐CD discriminated between patients with mild and severe disease. In conclusion, the frequency and activation of colonic neutrophils correlated with SES‐CD, highlighting that mucosal neutrophils are associated with disease severity in CD.

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Section: The Frequency Of Colonic Neutrophils Correlates With Ses-cdsupporting

confidence: 88%

Recruitment of activated neutrophils correlates with disease severity in adult Crohn’s disease

Therrien

Chapuy

Bsat

et al. 2018

Clinical and Experimental Immunology

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“…We previously reported a gating strategy to identify, purify, and sort viable mucosal basophils without contamination with IgE‐bearing dendritic cells . Here, we used the same gating strategy to detect basophils in the sputum of asthmatic patients.…”

Section: Resultsmentioning

confidence: 99%

Airway basophils are increased and activated in eosinophilic asthma

Suzuki

Wakahara

Nishio

et al. 2017

Allergy

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“…Basophilia is observed in the blood of patients with inflammatory bowel disease, including Crohn disease and ulcerative colitis. 62 Basophils accumulate in the inflamed colons of patients with these diseases. 62,63 Basophils appear to augment IL-17 and IFN-g production by memory CD4 1 T cells and therefore exacerbate inflammation.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Multifaceted roles of basophils in health and disease

Karasuyama

Miyake

Yoshikawa

et al. 2018

Journal of Allergy and Clinical Immunology

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Until recently, basophils had often been neglected in immunologic studies because of their minority status among immune cells or confused with tissue-resident mast cells because of some phenotypic similarities between them in spite of different anatomic localization. It is now appreciated that basophils and mast cells are distinct cell lineages and that basophils play important and nonredundant roles distinct from those played by mast cells. On the one hand, basophils contribute beneficially to protective immunity, particularly against parasitic infections. On the other hand, basophils are involved in the development of various disorders, including allergy and autoimmune disease. Basophils interact with other immune cells and nonhematopoietic cells through cell-to-cell contact or basophil-derived factors, such as cytokines and proteases, contributing to the regulation of immune and allergic responses. In this review article we highlight recent advances in our understanding of basophil pathophysiology in human subjects and animal models by consolidating research findings reported during the past 5 years. Further studies on basophils and their products will help identify suitable targets for novel therapeutics in allergy and effective vaccines against parasitic infection.

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Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory TH17/TH1 response

Cited by 27 publications

References 13 publications

Recruitment of activated neutrophils correlates with disease severity in adult Crohn’s disease

Recruitment of activated neutrophils correlates with disease severity in adult Crohn’s disease

Airway basophils are increased and activated in eosinophilic asthma

Multifaceted roles of basophils in health and disease

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