Basophilic cell progenitors, nasal metachromatic cells, and peripheral blood basophils in ragweed-allergic patients+

Otsuka, Hirokuni; Dolovich, J.; Befus, A D; Telizyn, S; Bienenstock, John; Denburg, Judah A.

doi:10.1016/s0091-6749(86)80091-4

Cited by 94 publications

(48 citation statements)

References 19 publications

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“…These findings complement long-standing observations that we and others had made on mast cell progenitors in the rat Nippostrongylus brasiliensis model (55,56) and on Eo-Bas0 progenitors in allergic rhinitis (57,58). What appears to be the case for mast cell accumulation in response to a parasitic antigen is thus probably the same for Eo-Baso progenitors in human allergen-induced disease.…”

Section: Mast Cell Lineagesupporting

confidence: 88%

“…2). Together with the findings in human allergic rhinitis and asthma exacerbation (57,58,87,89), such observations support the hypothesis that bone marrow progenitors respond to changes (allergen or steroids) in the airways during allergen-induced inflammatory responses. This would be in keeping with the knowledge we now have of cytokine production by inflamed airways tissues.…”

Section: Allergic Inflammationsupporting

confidence: 81%

“…We have extensive evidence of significant and relevant fluctuations in peripheral blood Eo-Bas0 progenitors in allergic airways disease (21-26, 57, 58, 86-88) ( Table 1 ). In general, allergic rhinitis and atopy patients appear to have constitutive increases in these progenitors, observed mainly out-of-season (57,58). Fluctuations in blood Eo-Baso progenitors occur during natural allergen exposure (57,58,89).…”

Section: Allergic Inflammationmentioning

confidence: 99%

“…In general, allergic rhinitis and atopy patients appear to have constitutive increases in these progenitors, observed mainly out-of-season (57,58). Fluctuations in blood Eo-Baso progenitors occur during natural allergen exposure (57,58,89). Eo-Baso progenitors not only rise in number during seasonal allergen exposure, but also within 24 h of allergen provocation in a controlled setting (86,88).…”

Section: Allergic Inflammationmentioning

confidence: 99%

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The role of the bone marrow in allergy and asthma

Denburg

Inman

Leber

et al. 1996

Allergy

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Summary The above studies have begun to address the fundamental question of the mechanisms of bone marrow involvement and response to allergen challenge in allergic asthmatics. Further studies in this area should complement our investigations in human asthma — which suggest that a particular bias toward differentiation of Eo‐Baso progenitors characterizes the atopic state — as well as our findings in the dog model of allergen‐induced airway hyperresponsiveness, which indicate that the bone marrow responds to inhalation of allergen or corticosteroids. Taken in the context of previous indications that IgE and bronchial responsiveness may both be transferrable through bone marrow transplantation (log), these findings indicate a physiologic role for the bone marrow in allergic inflammation. Likewise, these concepts provide a basis for making certain predictions regarding management and novel therapeutic interventions in atopy and asthma.

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Section: Mast Cell Lineagesupporting

confidence: 88%

Section: Allergic Inflammationsupporting

confidence: 81%

Section: Allergic Inflammationmentioning

confidence: 99%

Section: Allergic Inflammationmentioning

confidence: 99%

See 2 more Smart Citations

The role of the bone marrow in allergy and asthma

Denburg

Inman

Leber

et al. 1996

Allergy

View full text Add to dashboard Cite

show abstract

“…Atopy is associated with higher numbers of eosinophil-basophil progenitors, as measured by colony assays of human blood: in atopics there are greater numbers of eosinophil-basophil colonyforming units (Eo/B-CFU) (Denburg et al 1985, Otsuka et al 1986) and CD34 + cells than in non-atopic controls. Likewise, during an acute exacerbation of asthma, there is a significant rise in blood Eo/B-CFU, which falls upon clinical resolution of the exacerbation induced by inhaled corticosteroids (Gibson et al 1990).…”

Section: Peripheral Blood Eosinophil-basophil Pro-genitorsmentioning

confidence: 99%