Basophil Releasability in Human Hydatidosis

Aceti, Antonio; Celestino, D; Caferro, Marta; Teggi, Antonella; Pennica, Alfredo; Adriani, Emilio; Grilli, Anastasio; Paparo, Samuele Barbaro; Leri, O; Rosa, F. De; Sebastiani, A.

doi:10.1159/000235099

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Regarding basophils, the human basophil degranulation test was found to be positive in 33% of patients with hydatid disease (HD)[ 19 ]. Furthermore, evidence of increased histamine release from hydatid patient basophils following a challenge with anti-human IgE has also been obtained[ 20 ]. It can be concluded that both the generation of histamine releasing factor (HiRF) and production of IgE, which can bind cytokines, may be involved in this stage of infection[ 21 ].…”

Section: Immune Response To E Granulosus Infectiomentioning

confidence: 99%

Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review

Grubor

Jovanova-Nešić

Shoenfeld

2017

WJH

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Cystic echinococcosis (CE) is an infectious disease caused by the larvae of parasite Echinococcus granulosus (E. granulosus). To successfully establish an infection, parasite release some substances and molecules that can modulate host immune functions, stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host. The literature was reviewed using MEDLINE, and an open access search for immunology of hydatidosis was performed. Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity. In this review we used the existing scientific data and discuss how these findings assisted with a better understanding of the immunology of E. granulosus infection in man. The aim of this study is to point the several facts that challenge immune and autoimmune responses to protect E. granulosus from elimination and to minimize host severe pathology. Understanding the immune mechanisms of E. granulosus infection in an intermediate human host will provide, we believe, a more useful treatment with immunomodulating molecules and possibly better protection from parasitic infections. Besides that, the diagnosis of CE has improved due to the application of a new molecular tool for parasite identification by using of new recombinant antigens and immunogenic peptides. More studies for the better understanding of the mechanisms of parasite immune evasion is necessary. It will enable a novel approach in protection, detection and improving of the host inflammatory responses. In contrast, according to the “hygiene hypothesis”, clinical applications that decrease the incidence of infection in developed countries and recently in developing countries are at the origin of the increasing incidence of both allergic and autoimmune diseases. Thus, an understanding of the immune mechanisms of E. granulosus infection is extremely important.

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Section: Immune Response To E Granulosus Infectiomentioning

confidence: 99%

Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review

Grubor

Jovanova-Nešić

Shoenfeld

2017

WJH

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“…The generation of histamine releasing factor may ac count for the enhanced basophil releasability we have ob served in patients with E. granulosus infection [7]. Indeed, it is postulated that the production of this factor in vivo may also lead to the increased releasability of histamine by basophils reported in some patients with atopic dermatitis and to the cutaneous hyperreactivity seen in many such patients [15].…”

Section: Discussionmentioning

confidence: 86%

“…We have shown that Echinococcus granulosus infection can induce an enhanced sensitivity of basophils to IgEdependcnt stimuli [7]. Indeed, this hypcrrcleasable state makes it possible to obtain a high response to appropriate antigen, even though levels of cell-bound IgE are low [8].…”

Section: Introductionmentioning

confidence: 98%

Spontaneous in vitro Generation of Histamine Releasing Factor from Mononuclear Cells of Patients with Hydatidosis

Aceti¹,

Celestino²,

Teggi³

et al. 1992

Int Arch Allergy Immunol

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We have shown that Echinococcus granulosus infection can induce an enhanced sensitivity of basophils to IgE-dependent stimuli. To determine whether a cytokine, histamine releasing factor, could account for it, we evaluated 35 patients with active hydatidosis, 5 patients with past E. granulosus infection, and 20 normal volunteers. The spontaneous production of a factor in vitro that provoked the release of histamine from basophils was observed by mononuclear cells from patients with active disease, but not by those from subjects with past infection or from normal individuals. The histamine releasing factor was found to activate basophils through surface-bound IgE. It is concluded that E. granulosus infection induces both generation of histamine releasing factor and production of IgE that can bind this cytokine.

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Basophil-bound and serum immunoglobulin E directed against Helicobacter pylori in patients with chronic gastritis

et al. 1991

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Basophil Releasability in Human Hydatidosis

Cited by 3 publications

References 4 publications

Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review

Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review

Spontaneous in vitro Generation of Histamine Releasing Factor from Mononuclear Cells of Patients with Hydatidosis

Basophil-bound and serum immunoglobulin E directed against Helicobacter pylori in patients with chronic gastritis

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