Basigin-2 is the predominant basigin isoform that promotes tumor cell migration and invasion and correlates with poor prognosis in epithelial ovarian cancer

Zhao, Shuhua; Wang, Yu; Li, Wen; Zhai, Zhen-Bo; Ai, Zhen-Hua; N, Yao; Wang, Li; Li, Wenchao; Chen, Biliang; Yu, Li; Yang, Hong

doi:10.1186/1479-5876-11-92

Cited by 23 publications

(26 citation statements)

References 42 publications

(31 reference statements)

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“…EMMPRIN is up-regulated in a number of different cancers, in which its levels correlate with a poor prognosis in cancer patients [21,[91][92][93][94]. MMPs have been identified as potential therapeutic targets in cancers for a long time [95][96][97]; thus, EMMPRIN, an MMP-inducer, is becoming recognized as a suitable candidate for therapeutic intervention.…”

Section: Cancer/lymphomamentioning

confidence: 99%

The role of EMMPRIN in T cell biology and immunological diseases

Hahn

Kaushik

Yong

2015

Journal of Leukocyte Biology

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EMMPRIN (CD147), originally described as an inducer of the expression of MMPs, has gained attention in its involvement in various immunologic diseases, such that anti-EMMPRIN antibodies are considered as potential therapeutic medications. Given that MMPs are involved in the pathogenesis of various disease states, it is relevant that targeting an upstream inducer would make for an effective therapeutic strategy. Additionally, EMMPRIN is now appreciated to have multiple roles apart from MMP induction, including in cellular functions, such as migration, adhesion, invasion, energy metabolism, as well as T cell activation and proliferation. Here, we review what is known about EMMPRIN in numerous immunologic/inflammatory disease conditions with a particular focus on its complex roles in T cell biology.

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Section: Cancer/lymphomamentioning

confidence: 99%

The role of EMMPRIN in T cell biology and immunological diseases

Hahn

Kaushik

Yong

2015

Journal of Leukocyte Biology

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“…Firstly, this study updated the included study and two articles (Lahmann et al, 2009;Rossing et al, 2010) published after 2007 were included. The second one was that the cases in our study were patents with OC while in that study were patients with the most common OC, epithelial OC (Zhao et al, 2013). Furthermore, the intensity of RPA was estimated by MET value in the included studies of this meta-analysis.…”

Section: Discussionmentioning

confidence: 98%

Recreational Physical Activity and Risk of Ovarian Cancer: a Meta-analysis

Zhou¹

2014

Asian Pacific Journal of Cancer Prevention

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Our aim was to access the association between recreational physical activity (RPA) and risk of ovarian cancer (OC). The studies were retrieved from the PubMed and Embase databases up to February 20th, 2014. Risk ratios (OR) and 95% confidence intervals (CI) were used to estimate effect sizes. Random-effects or fixed-effects models were used to pool the data. The trim and fill method was applied for sensitivity analysis. Begg's rank correlation test and Egger's regression asymmetry test were employed to assess the publication bias. A total of 6 studies (435398 participants including 2983 OC patients) were included in this meta-analysis. The overall estimate indicated that there was weakly inverse association between RPA and OC risk (RR=0.90, 95%CI: 0.72-1.12, p=0.335). Meanwhile, for prospective cohort studies, a result consistent with the overall estimate was obtained (RR=1.12, 95% CI: 0.88-1.42, p=0.356). However, for case control studies, the pooled estimate of RR was 0.76 (95%CI: 0.64-0.90, p=0.002), indicating a clear significant association between RPA and OC risk. In addition, the sensitivity analysis indicated a significant link between RPA and risk of OC after removing Lahmann's study (RR=0.80, 95% CI: 0.68-0.93, p=0.004). No significant publication bias was found (Begg's test: p=1.00; Egger's test: p=0.817). In conclusion, our meta-analysis indicated a weakly inverse relationship between RPA and the occurrence of OC.

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“…Basigin-3 serves as an endogenous inhibitor of basigin-2 via hetero-oligomerization (Liao et al 2011). Basigin-4 was reported to be overexpressed in cervical cancer and promote proliferation of cervical cancer cells (Zhao et al 2013).…”

Section: Background On Basigin a Member Of The Ig Superfamilymentioning

confidence: 99%

The role of basigin in reproduction

Nowak

2020

Reproduction

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Basigin is a highly glycosylated transmembrane protein that was originally identified as a product of tumor cells. Basigin is a potent inducer of matrix metalloproteinases (MMPs) and angiogenic factors such as vascular endothelial growth factor (VEGF). Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism. Studies in reproductive model systems have demonstrated that basigin is expressed in the testis, ovary, uterus and placenta and is necessary for normal fertility in both males and females. Overexpression of basigin is associated with reproductive diseases including uterine leiomyomas and endometriosis. This review presents an overview of the literature regarding the physiological role of basigin in reproductive tissues and the mechanistic pathways involved in its actions.

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Basigin-2 is the predominant basigin isoform that promotes tumor cell migration and invasion and correlates with poor prognosis in epithelial ovarian cancer

Cited by 23 publications

References 42 publications

The role of EMMPRIN in T cell biology and immunological diseases

The role of EMMPRIN in T cell biology and immunological diseases

Recreational Physical Activity and Risk of Ovarian Cancer: a Meta-analysis

The role of basigin in reproduction

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