The role of basigin in reproduction

Abstract

Basigin is a highly glycosylated transmembrane protein that was originally identified as a product of tumor cells. Basigin is a potent inducer of matrix metalloproteinases (MMPs) and angiogenic factors such as vascular endothelial growth factor (VEGF). Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism. Studies in reproductive model systems have demonstrated that basigin is expressed in the testis, ovary, uterus and placenta and is necessary for normal fertility in both males and females. Overexpression of basigin is associated with reproductive diseases including uterine leiomyomas and endometriosis. This review presents an overview of the literature regarding the physiological role of basigin in reproductive tissues and the mechanistic pathways involved in its actions.

Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early‐onset preeclampsia

“…It has been linked to the physiology and pathology of various reproductive processes. 4 Systematic CD147 knockout leads to perinatal lethality before day 12.5 of gestation in mice. 5 The observations could be due to deficiency of CD147 in the foetus and/or the placenta.…”

“…CD147 has an unusual transmembrane domain characterised by a single-charged glutamic acid in the hydrophobic transmembrane region, which promotes proteinprotein interactions. 4 CD147 is a component of two receptor complexes (Figure 3F; Table S2) on the plasma membrane of human EVCT. The CD147-integrin β1 interaction within the complex was confirmed by protein interaction analysis (Figure 3F), coimmunoprecipitation (Figure 3G) and their specific expression in EVCT (Figures S1C and S4).…”

“…7 Indeed, CD147 has been proposed to regulate trophoblast differentiation in humans. 3,4 Analysis of singlecell databases of the human cell landscape and human early maternal-foetal interface revealed high expression of CD147 in the cytotrophoblast (CT) and EVCT (Figure S4). Taken together, we hypothesised that CD147 regulated placental development in humans by modulating EVCT differentiation and functions.…”

A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2

“…Moreover, DPP4 has been shown to be expressed on placental EVTs suppressing their invasion [ 81 ]. Also, CD147, the third suggested entry receptor for SARS-CoV-2 [ 54 ], plays various important physiological roles in reproductive tissues including the placenta [ 82 ]. CD147 is required for normal implantation by mediating gene expression in mouse uterine stromal cells during pregnancy [ 83 ].…”

The Network of Pro-Inflammatory Factors CD147, DcR3, and IL33 in the Development of Kawasaki Disease

“… 4 CD147 is a potent inducer of angiogenic factors such as VEGF. 5 It induced the up-regulation of VEGF-derived foam cells, which may further promote intraplaque angiogenesis through the PI3K/AKT pathway. 6 A study indicated elevated CD147 in pressure-overloaded exacerbated RV dysfunction while suppressing CD147, and its ligand Cyclophilin A(CyPA) can meliorate RV dysfunction in PH model animals.…”