Basidiobolus haptosporus-like fungus as a causal agent of gastrointestinal basidiobolomycosis

Bshabshe, Ali Al; Joseph, Martin R.P.; Khalid, Asaad; Azraqi, T. Al; Humayed, Sulieman Al; Hamid, Mohamed E.

doi:10.1093/mmy/myz046

Cited by 9 publications

(13 citation statements)

References 25 publications

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“…A previous study showed that a set of Basidiobolus spp. from Saudi Arabia clustered as a novel monophyletic lineage [ 7 ]. According to the same authors, these strains shared 99.97% ITS similarity with B. haptosporus and 99.97% with B. haptosporus var.…”

Section: Discussionmentioning

confidence: 99%

“…Infections have also been reported in dogs [ 3 ]. Human gastrointestinal basidiobolomycosis (GIB) is increasingly recognised in immunocompromised or otherwise debilitated patients [ 4 , 5 , 6 , 7 ]. This deep infection, recently described from the Middle East [ 7 ], may take a serious course.…”

Section: Introductionmentioning

confidence: 99%

“…Human gastrointestinal basidiobolomycosis (GIB) is increasingly recognised in immunocompromised or otherwise debilitated patients [ 4 , 5 , 6 , 7 ]. This deep infection, recently described from the Middle East [ 7 ], may take a serious course. The authors analysed 28S rDNA sequences of five strains and found them to cluster in a monophyletic branch close to B. haptosporus , having 99.97% similarity with the latter species and slightly lower (99.25%) with B. ranarum.…”

Section: Introductionmentioning

confidence: 99%

“…The recent report of gastrointestinal basidiobolomycosis from Saudi Arabia [ 7 ] was carefully analysed using 28S rDNA gene sequences of five strains. These were found to cluster in a monophyletic branch close to B. haptosporus , having 99.97% similarity with the latter species and slightly lower (99.25%) with B. ranarum.…”

Section: Introductionmentioning

confidence: 99%

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Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Al‐Hatmi

Balkhair

Al-Busaidi

et al. 2021

JoF

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Human infectious fungal diseases are increasing, despite improved hygienic conditions. We present a case of gastrointestinal basidiobolomycosis (GIB) in a 20-year-old male with a history of progressively worsening abdominal pain. The causative agent was identified as a novel Basidiobolus species. Validation of its novelty was established by analysis of the partial ribosomal operon of two isolates from different organs. Phylogeny of ITS and LSU rRNA showed that these isolates belonged to the genus Basidiobolus, positioned closely to B. heterosporus and B. minor. Morphological and physiological data supported the identity of the species, which was named Basidiobolus omanensis, with CBS 146281 as the holotype. The strains showed high minimum inhibitory concentrations (MICs) to fluconazole (>64 µg/mL), itraconazole and voriconazole (>16 µg/mL), anidulafungin and micafungin (>16 µg/mL), but had a low MIC to amphotericin B (1 µg/mL). The pathogenic role of B. omanensis in gastrointestinal disease is discussed. We highlight the crucial role of molecular identification of these rarely encountered opportunistic fungi.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Al‐Hatmi

Balkhair

Al-Busaidi

et al. 2021

JoF

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“…One of the severe forms of basidiobolomycosis is human gastrointestinal basidiobolomycosis (GIB). Most of the GIB cases were pediatrics and predominately reported from the south of Saudi Arabia (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Antifungal activities of artesunate, chloramphenicol, and cotrimoxazole againstBasidiobolusspecies, the causal agents of gastrointestinal basidiobolomycosis

Al‐Qahtani¹,

Joseph

Al‐Hakami

et al. 2021

Preprint

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Basidiobolus species (n =13) isolated from human gastrointestinal basidiobolomycosis and lizards were tested against artesunate, chloramphenicol, and cotrimoxazole. The three agents exhibited inhibitory actions against Basidiobolus species comparable to the known antifungals. The combined effects of artesunate + voriconazole and cotrimoxazole + voriconazole have significant synergic effects, p = 0.003 and p = 0.021, respectively. These are promising results that enhance accelerated combined treatment of GIB in humans particularly the combination of artesunate and voriconazole.

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Molecular Taxonomy

Hagen,

Walther,

Houbraken

et al. 2023

Diagnosis and Treatment of Fungal Infections

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Basidiobolus haptosporus-like fungus as a causal agent of gastrointestinal basidiobolomycosis

Cited by 9 publications

References 25 publications

Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Antifungal activities of artesunate, chloramphenicol, and cotrimoxazole againstBasidiobolusspecies, the causal agents of gastrointestinal basidiobolomycosis

Molecular Taxonomy

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