Basics of dentin-pulp tissue engineering

Karakaya, İzgen; Ulusoy, Nuran

doi:10.3934/bioeng.2018.3.162

Cited by 5 publications

(2 citation statements)

References 83 publications

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“…13 Regenerasi pulpa memiliki tiga komponen utama : 1) stem cell yang memiliki kemampuan untuk berdiferensiasi didalam sel jaringan asli, 2) scaffold, yang bertindak sebagai platform yang menyediakan matriks sementara untuk mengembangkan sel dan meniru matriks ekstraseluler alami, 3)growth factor yang dapat memberikan kemotaksis, diferensiasi dan proliferasi sel induk. 14 Terdapat dua strategi yang diterapkan untuk regenerasi pulpa gigi yaitu cell transplantation dan cell homing. Cell transplantation merupakan cell based, yang berarti mentransplantasikan sel punca eksogen yang dimasukan ke perancah/scaffold yang digabungkan dengan signaling molecules ke dalam sistem saluran akar untuk regenerasi.…”

Section: Regenerasi Pulpaunclassified

Peran Decellurarized Dental Pulp Sebagai Kandidat Biomaterial Baru Dalam Regenerasi Pulpa : Tinjauan Literatur

Pratiwi,

Salsabila

2024

stoma

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Pulp necrosis is one of the main diseases that are most often found in the teeth and mouth. Root canal treatment is the main solution for pulp necrosis, but its implementation can lead to tooth death and recurrent infections. Regenerating the pulp by transplanting scaffolds, stem cells, and growth factors into the root canal is an alternative that can be offered to treat pulpal disease by keeping the teeth vital. Scaffold plays an important role in pulp regeneration, one of which is the ECM scaffold derived from pulp which combines the micro-collagen structure along with bioactive molecules that are important for pulp regeneration and able to promote the differentiation and proliferation of stem cells. This literature review aimed to identify the role of decellularized dental pulp as a new biomaterial candidate in pulp regenerations. The method being used in this review is systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. Decellularized Dental Pulp as a New Biomaterial Candidate has a role in pulp regeneration.

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Section: Regenerasi Pulpaunclassified

Peran Decellurarized Dental Pulp Sebagai Kandidat Biomaterial Baru Dalam Regenerasi Pulpa : Tinjauan Literatur

Pratiwi,

Salsabila

2024

stoma

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“…Promising results of preclinical and clinical research led to the subsequent introduction of various growth factors to the commercial market for regeneration of soft and hard tissues [56]. However, there are several known problems associated with growth-factorbased therapy, which should be strictly taken into account: short periods of half-decay in vivo, side effects due to the introduction of several or high doses to achieve efficient therapy, unidentified key growth factors for particular tissues and the possible denaturation of protein during manipulation [5].…”

Section: Growth Factors and Signaling Moleculesmentioning

confidence: 99%

Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

Иванов

Кузнецова

Попова

et al. 2021

IJMS

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An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homing of endogenous stem cells has advantages in overcoming the limitations and risks associated with cell therapy. In this review, we discuss the potential of cell-free products such as the decellularized extracellular matrix, growth factors, extracellular vesicles and miRNAs in endogenous bone and dental regeneration.

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Dentin-Pulp Tissue Regeneration Approaches in Dentistry: An Overview and Current Trends

Şişmanoğlu

Ercal

2020

Advances in Experimental Medicine and Biology

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Basics of dentin-pulp tissue engineering

Cited by 5 publications

References 83 publications

Peran Decellurarized Dental Pulp Sebagai Kandidat Biomaterial Baru Dalam Regenerasi Pulpa : Tinjauan Literatur

Peran Decellurarized Dental Pulp Sebagai Kandidat Biomaterial Baru Dalam Regenerasi Pulpa : Tinjauan Literatur

Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

Dentin-Pulp Tissue Regeneration Approaches in Dentistry: An Overview and Current Trends

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