Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device

Nakagawa, Shinya; Kataoka, Takahiro; Sakoda, Akihiro; Hanamoto, Katsumi; Yamaoka, Kunihiro; Ishimori, Yuu

doi:10.3769/radioisotopes.57.241

Cited by 17 publications

(15 citation statements)

References 14 publications

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“…Another known effect of a radon spring is to promote the effects of such 10 tissue perfusion agents as adrenaline in plasma; specifically, the level of plasma adrenaline is increased by radon inhalation [28,29]. We previously reported that radon inhalation of a concentration of 4000 Bq/m 3 for 1 or 2 days significantly increases the antioxidative function of mouse liver and kidney [25]. In the current study, we attempted to shorten the inhalation time.…”

Section: Discussionmentioning

confidence: 99%

“…Most conditions treated with radon therapy are lifestyle-related diseases such as arteriosclerosis, osteoarthritis [23], and bronchial asthma [24]. To assess the effects of radon, we have co-developed a radon exposure system (OZ PLAN Co., Ltd. Okayama, Japan); radon inhalation using this system activated antioxidative functions in the liver, kidney, lung, and brain of mice, including suggesting the possibility of a new therapy to treat liver, kidney, lung, and brain damage [25].…”

Section: Introductionmentioning

confidence: 99%

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Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

et al. 2010

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“…Hepatic and renal damage are not the primary indications for radon therapy. However, we have shown previously that radon inhalation activates antioxidative functions in liver, kidney, lung, and brain of mice [17], and our results demonstrate that radon inhalation clearly inhibits oxidative damage in the liver and kidney of mice [18]. It is highly possible that radon inhalation activates defensive systems and, therefore, contributes to preventing or reducing ROS-related injuries, which are thought to involve peroxidation.…”

Section: Discussionmentioning

confidence: 59%

“…Most conditions treated with radon therapy are lifestyle-related diseases, such as arteriosclerosis, osteoarthritis [15], and bronchial asthma [16]. To assess the effects of radon, we have co-developed a radon-exposure system for small animals (OZ PLAN Co., Ltd. Okayama, Japan); using this system we demonstrated that radon inhalation activated antioxidative functions in the liver, kidney, lung, and brain of mice [17]. These findings indicate that radon inhalation may be used as a treatment for liver, kidney, lung, and brain damage.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

et al. 2011

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We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice.Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2000 Bq/m 3 of radon for 24 hr. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activity and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activate antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activity in paws were significantly higher in the radon-treated mice than the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.

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“…Low dose of alpha particle induces the production of ROS which then will induce the production of SOD and catalase. This activity inhibits several oxidative injuries such as hepatopathy and ischemia-reperfusion injury [14,18].…”

Section: Discussionmentioning

confidence: 99%

Superoxide Dismutase (SOD) Level in Blood of the People Living in High and Lowest Radon Exposure Area: A Study in Padalarang, West Java Indonesia

Azhari¹,

Suhardjo²,

Sitam³

et al. 2016

UCMS

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Abstract:Radon 222 released from rocks contribute to the level of radiation in human body. The stratigraphy of West Java, which is dominated by granite, has a high level of radon. The result of the study in Padalarang shows that the highest dose of radon is 24 Bq/kg and the lowest 17 Bq/kg. The alpha rays may affect the Superoxide Dismutase (SOD) level. The research is conducted on all men and women in the age of 30 to 70 living in Padalarang district who met the inclusion criteria, with good general health condition, being original inhabitant since birth, not suffering from chronic systemic infectious diseases, and willing to participate in the research by completing the informed consent. Sample is taken by using consecutive sampling. Blood sample is taken as much as 2 cc/person by using a 2cc syringe, which is then inserted into venoject tube containing heparin. Antioxidant activity in the blood plasma is examined by using SOD Kit. The average of SOD level is 3.56 ui/ml in Highland (Masigit Mountain) and 1.65ui/ml in lowland (Cipatat). The increase of SOD level of the people living in Highland is suspected to be the contribution of radon exposure contained in rocks and water.

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Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device

Cited by 17 publications

References 14 publications

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

Superoxide Dismutase (SOD) Level in Blood of the People Living in High and Lowest Radon Exposure Area: A Study in Padalarang, West Java Indonesia

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