2009
DOI: 10.1177/1538574408322752
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Basic Science Review: Nitric Oxide—Releasing Prosthetic Materials

Abstract: Prosthetic devices that come into contact with blood ultimately fail secondary to thrombus formation. This limits the utility of a variety of materials used to surgically treat cardiovascular disease, including vascular grafts and stents, as well as sensors and catheters placed within the circulatory system. Moreover, systemic anticoagulation that is used to prevent malfunction of these devices has potential for serious complications. It is known that nitric oxide (NO) produced via the endothelium imparts thro… Show more

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Cited by 40 publications
(53 citation statements)
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“…Inhaled NO gas diffuses rapidly across the alveolar-capillary membrane and activates sGC in the subjacent smooth muscle cells in the pulmonary vasculature (69). N-diazeniumdiolates (NONOates) are NO donors that are synthesized by reacting primary or secondary amines with NO gas at high pressure and low temperatures; hydrolysis causes spontaneous decomposition under physiological conditions and releases NO (7072). Nitric oxide (as N 2 O 3 or − ONOO) can react with thiols in vivo to form S-nitrosothiols, such as S-nitrosocysteine and S-nitrosoglutathione (73).…”
Section: Preparationsmentioning
confidence: 99%
“…Inhaled NO gas diffuses rapidly across the alveolar-capillary membrane and activates sGC in the subjacent smooth muscle cells in the pulmonary vasculature (69). N-diazeniumdiolates (NONOates) are NO donors that are synthesized by reacting primary or secondary amines with NO gas at high pressure and low temperatures; hydrolysis causes spontaneous decomposition under physiological conditions and releases NO (7072). Nitric oxide (as N 2 O 3 or − ONOO) can react with thiols in vivo to form S-nitrosothiols, such as S-nitrosocysteine and S-nitrosoglutathione (73).…”
Section: Preparationsmentioning
confidence: 99%
“…These compounds are known as NO donors. Of these, nitroglycerin might be the most prominent one, which can release one molar equivalent of NO by trinitrate species conversion upon inhalation, oral or transdermal administration targeting mitochondrial enzymes as described in Section 2.1 [50,112]. It is one of the low molecular weight (LMW) organic nitrate donors commonly used as vasodilator drugs in modern medicine for delivery of NO.…”
Section: Mechanisms Of Nitric Oxide Producing Materialsmentioning
confidence: 98%
“…The predictable first-order release kinetics of NO depend on the exact atomic structure and amount of amine precursor, which can vary from short time periods (seconds) to days or even weeks due to hydrogen bonding stabilization from additional amines. Furthermore, by specific modification in the chemistry of NONOates, local NO release at target sites might be achieved using a cell/tissue-specific enzyme or metabolitesas cleavable linkers [112]. However there are concerns about toxicity issues of nitrosamines, which are formed by hydrophilic diazeniumdiolates leaching from the polymer matrix [116].…”
Section: Mechanisms Of Nitric Oxide Producing Materialsmentioning
confidence: 99%
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“…These NO donors are incorporated into materials either by blending discrete NO donors within polymeric films, or by covalently attaching them to polymer backbones and/or to the inorganic polymeric filler particles that are often employed to enhance the strength of biomedical polymers (e.g., fumed silica or titanium dioxide). [28] N -diazeniumdiolates[26, 29, 30] and S -nitrosothiols[3032] are commonly used to prepare NO releasing polymeric matrices for improved biocompatibility of blood-contacting medical devices. The N -diazeniumdiolates are generally synthesized by reaction of amines with NO gas to form relatively stable compounds that release NO when in contact with bodily fluids through proton or thermally driven mechanisms.…”
Section: Introductionmentioning
confidence: 99%