Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry

Mattei, Daniele; Notter, Tina

doi:10.1007/7854_2018_83

Cited by 28 publications

(18 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammation is seen as an integral part of the mechanisms of CNS homeostatic repair and defense [63]. The immune system is involved in many CNS processes, including neurodevelopment, synaptic plasticity, and circuit maintenance [64]. Thus, neuroinflammation is a multifaceted process.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, neuroinflammation is a multifaceted process. The process of neuroinflammation includes (1) induction of a local immune response by immune cells in the CNS, (2) higher production of pro-inflammatory cytokines and chemokines, (3) additional recruitment of immune cells from the CNS to the primary site of injury or infection, (4) permeability of the blood-encephalic barrier and leukocyte penetration, from blood to brain, and (5) resolving inflammation and tissue remodeling [64].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

Morozova

Zorkina

Abramova

et al. 2022

IJMS

View full text Add to dashboard Cite

This review is focused on several psychiatric disorders in which cognitive impairment is a major component of the disease, influencing life quality. There are plenty of data proving that cognitive impairment accompanies and even underlies some psychiatric disorders. In addition, sources provide information on the biological background of cognitive problems associated with mental illness. This scientific review aims to summarize the current knowledge about neurobiological mechanisms of cognitive impairment in people with schizophrenia, depression, mild cognitive impairment and dementia (including Alzheimer’s disease).The review provides data about the prevalence of cognitive impairment in people with mental illness and associated biological markers.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

Morozova

Zorkina

Abramova

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Microglia constantly survey the local microenvironment and express a unique sensome that dynamically and heterogeneously regulates synaptic connectivity and remodeling in both developing and mature brains (Hong et al, 2016; Masuda et al, 2020; Smolders et al, 2019; Tan et al, 2020; Tay et al, 2017). Dysfunction of microglia and their genes in psychiatric disorders have been extensively documented, and as a sensitive target of psychosocial stress, microglia are mostly regarded as triggering or exacerbating mental disorders in the current literature (Delpech et al, 2015; Hodes et al, 2015; Johnson & Kaffman, 2018; Mattei & Notter, 2020; Mondelli et al, 2017; Wohleb et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Microglia contribute to social behavioral adaptation to chronic stress

Piirainen

Chithanathan

Bisht

et al. 2021

Glia

View full text Add to dashboard Cite

Microglial activation has been regarded mainly as an exacerbator of stress response, a common symptom in psychiatric disorders. This study aimed to determine whether microglia contribute to adaptive response of the brain and behavior toward stress using a mild and adaptive stress model – chronic restraint stress (CRS) – with wild type (WT) and CX3CR1‐GFP (CX3CR1[G]) mice and human schizophrenia patients' data. Our results revealed that CRS did not exacerbate anxiety and depressive‐like behaviors, but instead strengthened social dominance and short‐term spatial learning in WT mice. Compared to WT and CX3CR1(+/G) heterozygous mice, CX3CR1(G/G) homozygotes were subordinate in social interaction before and after CRS. Microglia in WT mice underwent a series of region‐specific changes involving their phagocytosis of presynaptic vesicular glutamate transporter 2 protein, contacts with synaptic elements, CD206+microglial proportion, and gene expressions such as Cx3cr1. By contrast, CX3CR1‐deficient microglia showed decreased CD206+ while increased MHCII+ subpopulations and hypo‐ramification in the hippocampus, as well as sensitized polarization and morphological change in response to CRS. Furthermore, CD206+ microglial abundancy was positively correlated with social dominancy and microglial ramification in CX3CR1‐GFP mice. Moreover, CX3CR1 mRNA level was reduced in CRS‐treated mouse brains and showed a smaller interactome with other brain genes in the dorsal‐lateral prefrontal cortices of patients with schizophrenia. Our findings overall highlight microglia and its receptor CX3CR1 as key contributors in regulation of social behavioral adaptation to chronic stress.

show abstract

“…Studies on yoga and other mind-body interventions suggest that these practices positively affect gene expression profiles; for example, they may lead to a reduced risk of inflammation-related diseases (20). Multiple lines of evidence (preclinical, genetics, and bioinformatics) show an activation of immune system molecules and pathways that can contribute to psychiatric disorders' pathogenesis (21)(22)(23).…”

Section: Psychological/behavioral Changes Induced By Yogamentioning

confidence: 99%

Yoga as Complementary Care for Young People Placed in Juvenile Institutions—A Study Plan

Kerekes

2021

Front. Psychiatry

View full text Add to dashboard Cite

Recent studies have established yoga practice as a mainstream complementary clinical tool within correctional environments. It is shown that regular yoga practice is coupled with improved impulse control, sustained attention, attenuated antisocial and self-harm behaviors, reduced stress, and psychological distress. No academic research until now has provided evidence of mental health benefits of yoga for institutionalized young people. In Sweden, each year more than thousand adolescents receive compulsory care at juvenile institutions run by the Swedish National Board of Institutional Care. These young people are characterized by substance abuse, aggressive and antisocial behaviors, high frequency of self-harm, and the experience of abuse. Most of them manifest attention problems, depression, anxiety, and impulsivity. They have a dramatically increased risk for recidivistic criminal behavior, continuous medical, and social care and untimely death. The present study plan aims at evaluating, with previously validated psychological measures, in a quasi-experimental design, the effects of yoga practice for institutionalized adolescents. Adolescents' experiences of participating in yoga practice will also be assessed by semi-structured individual interviews. Ethical approval was given by the Swedish Ethical Review Authority. It is hypothesized that yoga practice (in combination with the standard treatment within institutional care) will reduce institutionalized adolescents' aggression, antisocial behavior, anxiety, depression, and negative affect, and increase their cognitive flexibility (in the form of increased impulse control).

show abstract

Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry

Cited by 28 publications

References 185 publications

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

Microglia contribute to social behavioral adaptation to chronic stress

Yoga as Complementary Care for Young People Placed in Juvenile Institutions—A Study Plan

Contact Info

Product

Resources

About