Basement membranes

Kramer, James M.

doi:10.1895/wormbook.1.16.1

Cited by 78 publications

(114 citation statements)

References 17 publications

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“…We observed frequent basement membrane abnormalities in dig-1 mutant animals. Specifically, in addition to the layer of basement membrane normally found to lie directly apposed to the plasma membrane of muscle, hypodermal and pharyngeal cells (Kramer, 2005) (Fig. 1), dig-1 mutants exhibit multiple supplementary layers of basement membrane that form stacks and loose whorls (Fig.…”

Section: Dig-1 Functions Non-autonomously For Neuronal Maintenancementioning

confidence: 99%

“…7. dig-1 macromolecular assemblies of proteins and proteoglycans that are secreted from various tissues, including muscles and the hypodermis (schematically shown in Fig. 1) (Kramer, 2005;White et al, 1986). DIG-1 could be a component of the basement membrane that interacts with several other basement membrane proteins and proteoglycans via its multiple protein-protein interaction domains.…”

Section: Research Articlementioning

confidence: 99%

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DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture

et al. 2006

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Dedicated mechanisms exist to maintain the architecture of an animal's nervous system after development is completed. To date, three immunoglobulin superfamily members have been implicated in this process in the nematode Caenorhabditis elegans: the secreted two-Ig domain protein ZIG-4, the FGF receptor EGL-15 and the L1-like SAX-7 protein. These proteins provide crucial information for neuronal structures, such as axons, that allows them to maintain the precise position they acquired during development. Yet, how widespread this mechanism is throughout the nervous system, and what other types of factors underlie such a maintenance mechanism, remains poorly understood. Here, we describe a new maintenance gene, dig-1, that encodes a predicted giant secreted protein containing a large number of protein interaction domains. With 13,100 amino acids, the DIG-1 protein is the largest secreted protein identifiable in any genome database. dig-1 functions post-developmentally to maintain axons and cell bodies in place within axonal fascicles and ganglia. The failure to maintain axon and cell body position is accompanied by defects in basement membrane structure, as evidenced by electron microscopy analysis of dig-1 mutants. Expression pattern and mosaic analysis reveals that dig-1 is produced by muscles to maintain nervous system architecture, demonstrating that dig-1 functions non-autonomously to preserve the proper layout of neural structures. We propose that DIG-1 is a component of the basement membrane that mediates specific contacts between cellular surfaces and their environment through the interaction with a cell-type specific set of other maintenance factors.

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Section: Dig-1 Functions Non-autonomously For Neuronal Maintenancementioning

confidence: 99%

Section: Research Articlementioning

confidence: 99%

DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture

et al. 2006

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“…The first three are present in the two BMs separating the somatic gonad from the vulva, although it is not always known which tissue produces each of them, and are essential for development. 4 Perlecan is found at the muscle-epidermis interface and is secreted by the epidermis. 5 It provides a polarizing signal to initiate the assembly of muscle sarcomeres and impacts on the assembly of epidermal hemidesmosomes.…”

Section: Composition Of the Basement Membranementioning

confidence: 99%

“…12 Perlecan and myotactin null mutations arrest embryonic elongation midway and disrupt the muscleepidermis connection. 5,7,12 Since the review mentioned above, 4 A. Chisholm and his collaborators characterized two additional BM components located at the muscle-epidermis interface: an ECM spondin-family homolog (SPON-1) and a peroxidasin homolog (PXN-2). 9,10 A conserved catalytic residue among peroxidases is essential for PXN-2 function, suggesting that PXN-2 has peroxidase activity, but its endogenous substrates remain unknown.…”

Section: Composition Of the Basement Membranementioning

confidence: 99%

Role of the extracellular matrix in epithelial morphogenesis

Labouesse

2012

Organogenesis

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“…The intestine is composed of large cells, with distinct apical, lateral and basal membrane domains. Each intestinal cell forms part of the intestinal lumen at its apical pole (Fig.5E'-E'') and contains a basal lamina at its basal pole (Kramer, 2005), whose constituents are either made by the intestine itself (laminin and nidogen/entactin) or by the muscle and somatic gonad (type IV collagen). Many microvilli extend into the lumen from the apical surface, forming a brush border.…”

Section: Development and Differentiation Of The C Elegans Embryonic mentioning

confidence: 99%