Basement membranes in development and disease

Wiradjaja, Fenny; DiTommaso, Tia; Smyth, Ian

doi:10.1002/bdrc.20172

Cited by 46 publications

(47 citation statements)

References 245 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most abundant proteins in basement membrane areas are type IV collagen and laminin, but also nidogen, fibulin-1, type XVIII collagen, and basement membrane heparan sulfate proteoglycan (perlecan) are part of the protein constituency. 35 In contrast to the other identified basement membrane molecules, we did not observe changes in the arterial concentration of basement membrane heparan sulfate proteoglycan, which fits well with a few older reports about measurements of perlecan in glomeruli, showing that the amount of this molecule is actually reduced in DM, when judged in relation with the amount of collagen. 36 Importantly, although these data, also concerning laminin chains, may indicate that not only the amount but perhaps also the qualitative composition of the arterial basement membranes is changed in DM, a conclusion will have to await further studies.…”

Section: Discussionsupporting

confidence: 91%

Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower Levels Among Metformin Users

Preil

Kristensen

Beck

et al. 2015

Circ Cardiovasc Genet

View full text Add to dashboard Cite

The arterial pathology in DM does not only include increased occurrence of atherosclerotic plaques but also comprises generalized arterial alterations, that is, endothelial dysfunction, increased stiffness, extracellular matrix (ECM) changes and calcifications, which can be observed in both atherosclerotic and nonatherosclerotic parts of the arterial tree. Generalized changes in the vascular ECM have been described among patients with T1DM, that is, for glycosaminoglycans, 3 glycoproteins, 4,5 and collagens. 6 More recently, alterations in the levels of the metalloproteinase, matrix metalloproteinase Background-The increased risk of cardiovascular diseases in type 2 diabetes mellitus has been extensively documented, but the origins of the association remain largely unknown. We sought to determine changes in protein expressions in arterial tissue from patients with type 2 diabetes mellitus and moreover hypothesized that metformin intake influences the protein composition. Methods and Results-We analyzed nonatherosclerotic repair arteries gathered at coronary bypass operations from 30 patients with type 2 diabetes mellitus and from 30 age-and sex-matched nondiabetic individuals. Quantitative proteome analysis was performed by isobaric tag for relative and absolute quantitation-labeling and liquid chromatography-mass spectrometry, tandem mass spectrometry analysis on individual arterial samples. The amounts of the basement membrane components, α1-type IV collagen and α2-type IV collagen, γ1-laminin and β2-laminin, were significantly increased in patients with diabetes mellitus. Moreover, the expressions of basement membrane components and other vascular proteins were significantly lower among metformin users when compared with nonusers. Patients treated with or without metformin had similar levels of hemoglobin A1c, cholesterol, and blood pressure. In addition, quantitative histomorphometry showed increased area fractions of collagen-stainable material in tunica intima and media among patients with diabetes mellitus. Conclusions-The distinct accumulation of arterial basement membrane proteins in type 2 diabetes mellitus discloses a similarity between the diabetic macroangiopathy and microangiopathy and suggests a molecular explanation behind the alterations in vascular remodeling, biomechanical properties, and aneurysm formation described in diabetes mellitus. The lower amounts of basement membrane components in metformin-treated individuals are compatible with the hypothesis of direct beneficial drug effects on the matrix composition in the vasculature. (Circ Cardiovasc Genet. 2015;8:727-735.

show abstract

Section: Discussionsupporting

confidence: 91%

Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower Levels Among Metformin Users

Preil

Kristensen

Beck

et al. 2015

Circ Cardiovasc Genet

View full text Add to dashboard Cite

show abstract

“…During development and also in the adult, it is clear that vascular basement membrane matrix assembly represents a fundamental step in the maturation of vessels (Miner and Yurchenco 2004;Davis and Senger 2005;Rhodes and Simons 2007;Eble and Niland 2009;Stratman et al 2009a;Wiradjaja et al 2010). This is an example where the functional roles of such matrices in adults and embryos appear very similar.…”

Section: Distinctions Between the Compositions Of Embryonic And Adultmentioning

confidence: 99%

Angiogenesis

Senger¹,

Davis²

2011

Cold Spring Harbor Perspectives in Biology

307

302

View full text Add to dashboard Cite

Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult, angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement membrane, and vascular sprouting within interstitial matrix. During this sprouting phase, ECM binding to integrins provides critical signaling support for EC proliferation, survival, and migration. ECM also signals the EC cytoskeleton to initiate blood vessel morphogenesis. Dynamic remodeling of ECM, particularly by membrane-type matrix metalloproteases (MT-MMPs), coordinates formation of vascular tubes with lumens and provides guidance tunnels for pericytes that assist ECs in the assembly of vascular basement membrane. ECM also provides a binding scaffold for a variety of cytokines that exert essential signaling functions during angiogenesis. In the embryo, ECM is equally critical for angiogenesis and vessel stabilization, although there are likely important distinctions from the adult because of differences in composition and abundance of specific ECM components.T he extracellular matrix (ECM) provides a critical framework for angiogenesis through structural support and also by conferring molecular signals essential for all stages of blood vessel formation, including vascular sprouting, lumen formation, vessel maturation, and ultimately vessel stabilization. In addition, ECM provides an immobilizing scaffold for cytokines that are important for angiogenesis. Thus, by providing basic structural support, direct signaling functions, and scaffolding for cytokines, ECM exerts fundamental control over angiogenesis. Moreover, the established functional complexity of ECM together with known mechanisms available for dynamic ECM remodeling suggest that ECM is capable of exerting precise control over all aspects of angiogenesis and blood vessel maturation.This article is divided into four parts: (1) Overview of angiogenesis and ECM in the adult; (2) key functions of ECM during angiogenesis; (3) distinctions between the composition of embryonic and adult ECMs, including implications for the involvement of specific integrins in angiogenesis; and (4) ECM remodeling during vascular tube formation and stabilization. The scientific literature on ECM and angiogenesis is vast, and it is therefore impossible to cover this topic completely in a single article. Thus, rather than striving for an exhaustive review of

show abstract

“…These complexes are widely OPEN ACCESS distributed in the whole body and are an important part of the architecture of many tissues, such as skin, skeletal muscle, nerve, cornea, blood vessel and various glands ( Figure 1). In these tissues, epithelial cells adhere to the BMs via more than 20 types of cell surface receptors, including integrins, syndecans, α-dystroglycan and the immunoglobulin superfamily [4][5][6]. BM is comprised of at least four ECM components: type IV collagen, laminin, nidogen and perlecan.…”

Section: Introductionmentioning

confidence: 99%

Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane

et al. 2015

View full text Add to dashboard Cite

Abstract:The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellular functions for tissue engineering. We have developed laminin-derived active peptide-chitosan matrices as functional scaffolds. The biological activity of the peptides was enhanced when the peptides were conjugated to a chitosan matrix, suggesting that the peptide-chitosan matrix approach has an advantage for an active biomaterial. Further, the laminin peptide-chitosan matrices have the potential to mimic the basement membrane and are useful for tissue engineering as an artificial basement membrane.

show abstract

Basement membranes in development and disease

Cited by 46 publications

References 245 publications

Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower Levels Among Metformin Users

Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower Levels Among Metformin Users

Angiogenesis

Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane

Contact Info

Product

Resources

About