Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis

Fu, Shihui; Jin, Rongjie; Luo, Li

doi:10.1186/s12986-017-0229-8

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…Importantly, the patient had no history of renal impairment, cardiac disease, or diabetes. Recent studies, both cross-sectional and longitudinal, have highlighted the association between elevated hsTnT levels and diabetes mellitus, consistent with our findings ( 38 , 39 ). HsTnT has even been proposed as a predictor of incident diabetes ( 40 ).…”

Section: Discussionsupporting

confidence: 93%

Serum Troponin T Concentrations Are Frequently Elevated in Advanced Skin Cancer Patients Prior to Immune Checkpoint Inhibitor Therapy: Experience From a Single Tertiary Referral Center

et al. 2021

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Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of several human malignancies, particularly metastatic skin cancer. However, immune-related myocarditis (irM), an immune-mediated adverse event (irAE), is often fatal. In the absence of a reliable biomarker, measurement of pre-ICI therapy serum troponin concentration has been proposed to identify patients at risk of developing irM, although real-world studies examining this strategy are lacking. Thus, we retrospectively analyzed the case records of all patients who commenced ICI therapy between January 2018 and December 2019 in a single university skin cancer center (n = 121) to (i) determine the incidence of irM, (ii) establish the frequency of pretreatment serum hsTnT elevations, and (iii) to establish whether this identified patients who subsequently developed irM. Only one patient developed irM, resulting in an overall incidence of 0.8%. Pretreatment hsTnT was measured in 47 patients and was elevated in 13 (28%). Elevated serum hsTnT concentrations were associated with chronic renal failure (p = 0.02) and diabetes (p < 0.0002). Pretreatment hsTnT was not elevated in the patient who developed fulminant irM. Pre-immunotherapy serum hsTnT concentrations were often asymptomatically elevated in patients with advanced skin cancer, none of whom subsequently developed irM during ICI therapy. However, large studies are required to assess the positive and negative predictive values of hsTnT for the development of irM. In the meantime, elevated hsTnT concentrations should be investigated before initiation of immunotherapy and closely monitored during early treatment cycles, where the risk of irM is greatest.

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Section: Discussionsupporting

confidence: 93%

Serum Troponin T Concentrations Are Frequently Elevated in Advanced Skin Cancer Patients Prior to Immune Checkpoint Inhibitor Therapy: Experience From a Single Tertiary Referral Center

et al. 2021

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“…Similarly, a previous study by Fu et al (24) found a significant connection between type 2 diabetes and high hs-cTnT levels in models of multivariate logistic regression (p value < 0.05). In multivariate linear regression models, elevated levels of postprandial blood glucose (p < 0.05) rather than fasting blood glucose (p > 0.05) discovered the important relationship with higher hs-cTnT levels.…”

Section: Discussionsupporting

confidence: 68%

High Sensitivity Cardiac Troponin T in Patients with Type 2 Diabetes Mellitus, Relation to Cardiac Metabolic Risk Factors: Hypertension and Truncal Obesity

Asy

Ahmed²,

Attia³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Diabetes mellitus type 2 (T2DM) is a prevalent metabolic disease that predisposes to diabetic cardiomyopathy and cardiovascular diseases (CVD). High sensitivity cardiac troponin T (hs-cTnT) can determine who is most at risk for developing cardiovascular issues and diabetes. Objective: To evaluate the relation between high-sensitive cardiac troponin T and cardiac metabolic risks (hypertension and truncal obesity) in patient with T2DM. Patients and Methods: A prospective cohort study included 50 diabetic patients reached at the emergency units of

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“…In this study, admission blood glucose level, age, and history of antiplatelet drug use were found to be risk factors for elevated troponin. Type 2 diabetes has been proven to have a significant association with elevated hs-cTnT levels in community-dwelling population; fasting blood glucose played a crucial role in this association [ 36 ]. Sharain et al studied 830 patients and found that older age was also associated with elevated hs-cTnT [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Changes of Electrocardiogram and Myocardial Enzymes in Patients with Intracerebral Hemorrhage

et al. 2022

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Purpose. Cardiac complications are common in patients with spontaneous intracerebral hemorrhage (ICH). The present study is aimed at observing the incidence of cardiac complications after ICH, so as at improving the understanding of the relationship between cardiac complications and ICH. Methods. This is a retrospective study on analyzing electrocardiogram (ECG) and serum myocardial enzyme of 208 patients with ICH admitted to a tertiary hospital from 2018 to 2019. For each patient, demographics, medical history, clinical presentation, ECG, serum myocardial enzyme, and head CT on admission were reviewed. Mortality was noted. Results. Among the 208 patients, 145 (69.71%) had one or more ECG abnormalities. The top three abnormalities were corrected QT interval (QTc) prolongation 52 (25%), ST depression 48 (23.08%), and T wave inversion 38 (18.27%). One hundred and thirty-nine patients (66.83%) had increased serum levels of at least one kind of myocardial enzyme, which were high-sensitive cardiac troponin T (hs-cTnT) 79 (37.98%), lactic dehydrogenase (LDH) 80 (38.46%), creatine kinase (CK) 57 (27.40%), and creatine kinase-myocardial subfraction (CKMB) 57 (27.40%). The logistic regression analysis showed the following: secondary intraventricular hemorrhage (SIVH) (odds ratio (OR) 5.32; 95% confidence interval (CI) 2.55–11.08; p < 0.001 ) and hematoma volume > 30 ml (OR 3.81; 95% CI 1.86–7.81; p < 0.001 ) were independent predictive factors of QTc prolongation; thalamus location (OR 5.79; 95% CI 1.94–17.28; p < 0.05 ), hematoma volume > 30 ml (OR 24.187; 95% CI 3.14-186.33; p < 0.05 ), insular involvement (OR 19.08; 95% CI 5.77-63.07; p < 0.001 ), and SIVH (OR 2.62; 95% CI 1.69-5.86; p < 0.05 ) were independent predictive factors of ST depression; insular involvement (OR 2.90; 95% CI 1.12–7.50; p < 0.05 ) and hematoma volume > 30 ml (OR 1.98; 95% CI 1.06–3.70; p < 0.05 ) were independent predictive factors of increase of CK; Glasgow Coma Scale (GCS) (OR 0.86; 95% CI 0.78–0.98; p < 0.05 ) and insular involvement (OR 5.56; 95% CI 1.98–15.62; p < 0.05 ) were independent predictive factors of increase of CKMB; SIVH (OR 2.05; 95% CI 1.07–3.92; p < 0.05 ) was independent predictive factor of increase of LDH; age (OR 1.03; 95% CI 1.01–1.06; p < 0.05 ), blood glucose on admission (OR 1.10; 95% CI 1.01–1.20; p < 0.05 ), and history of antiplatelet drug use (OR 3.50; 95% CI 1.01–12.12; p < 0.05 ) were independent predictive factors of hs-cTnT. All the injury indexes were not related to in-hospital mortality. Conclusion. The study suggests that insular involvement, hematoma volume > 30 ml, and SIVH are the strongest risk factors for ECG abnormalities and elevated myocardial enzymes after ICH followed which are the risk factors such as GCS, age, admission blood glucose, and ICH location in the thalamus.

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Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis

Cited by 6 publications

References 20 publications

Serum Troponin T Concentrations Are Frequently Elevated in Advanced Skin Cancer Patients Prior to Immune Checkpoint Inhibitor Therapy: Experience From a Single Tertiary Referral Center

Serum Troponin T Concentrations Are Frequently Elevated in Advanced Skin Cancer Patients Prior to Immune Checkpoint Inhibitor Therapy: Experience From a Single Tertiary Referral Center

High Sensitivity Cardiac Troponin T in Patients with Type 2 Diabetes Mellitus, Relation to Cardiac Metabolic Risk Factors: Hypertension and Truncal Obesity

Changes of Electrocardiogram and Myocardial Enzymes in Patients with Intracerebral Hemorrhage

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