Baseline results of the Depiscan study: A French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR)

Blanchon, Thierry; Bréchot, J.-M.; Greniér, Philippe; Ferretti, G.; Lemarié, É.; Milleron, B.; Chagué, D; Laurent, François; Martinet, Yves; Beigelman-Aubry, Cathérine; Blanchon, F; Revel, Marie‐Pierre; Friard, S.; Rémy‐Jardin, Martine; Vasile, Manuela; Santelmo, Nicola; Lecalier, Alain; Lefebure, P.; Moro-Sibilot, Denis; Breton, Jean-Luc; Carette, Marie-France; Brambilla, Christian; Fournel, François; Kieffer, Alexia; Frija, G.; Flahault, Antoine

doi:10.1016/j.lungcan.2007.05.009

Cited by 241 publications

(157 citation statements)

References 41 publications

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“…Preliminary data from four randomized controlled trials (RCTs) using CT screening in the intervention arm have been published (16)(17)(18)(19)(20)(21). Three of these trials were conducted in advance of large multi-center national trials to determine the feasibility of enrollment into a randomized trial by generalists (16)(17)(18).…”

Section: Findings From Preliminary Randomized Controlled Trialsmentioning

confidence: 99%

“…Three of these trials were conducted in advance of large multi-center national trials to determine the feasibility of enrollment into a randomized trial by generalists (16)(17)(18). The Depiscan, conducted in France, involved 765 subjects randomized to receive either low dose CT or CXR at baseline and annually for two years.…”

Section: Findings From Preliminary Randomized Controlled Trialsmentioning

confidence: 99%

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Lung Cancer Screening with CT

Aberle

Brown

2008

Clinics in Chest Medicine

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Lung cancer is the leading cause of cancer death in the United States. In 2007, it is estimated that 160,390 lung cancer deaths will occur in the US, representing 29% of all cancer deaths (1). Roughly 87% of lung cancers are attributed to cigarette smoking (2). Although cancer risk is attenuated by smoking cessation, the risk is not eliminated, and lung cancer now occurs with equal frequency in current and former smokers (3). Moreover, other factors clearly influence risk, including age; family history; chronic obstructive pulmonary disease; pulmonary fibrosis; and exposures to environmental radon, asbestos, and certain other occupational agents (4). Realistically, lung cancer will likely remain at epidemic proportions for decades to come.Non-small cell lung cancer (NSCLC), which accounts for 75-80% of all lung cancers, is typically diagnosed when disease is locally advanced or there are systemic metastases (5), explaining the dismal overall five-year survival of 15% (6). In contrast, the five-year survival of individuals with surgically resected, early stage NSCLC approaches 75% (6,7). These differences have fueled the impetus to find a screening test that can detect NSCLC in its early preclinical stages, when surgical resection is most likely to prolong life and potentially reduce lung cancer mortality. Although earlier randomized controlled trials of lung cancer screening using chest radiography and sputum cytology failed to show reduced lung cancer mortality, computed tomography (CT) is a much more sensitive test for detecting small lung nodules, and has generated considerable enthusiasm as a potential contemporary screening tool for lung cancer.

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Section: Findings From Preliminary Randomized Controlled Trialsmentioning

confidence: 99%

Section: Findings From Preliminary Randomized Controlled Trialsmentioning

confidence: 99%

Lung Cancer Screening with CT

Aberle

Brown

2008

Clinics in Chest Medicine

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“…In addition, many screening programs have adopted a 5 mm diameter nodule size as the cutoff between positive and negative nodules on CT 1 , 2 , 3 , 4 , 5 , 6 , 7 . Therefore, we used 6 mm HGGOs and analyzed the relationship between the visibility, SNR M 2 and CTDI vol .…”

Section: Methodsmentioning

confidence: 99%

“…Low‐dose computed tomography (CT) for lung cancer screening has been well established as a more effective method of detecting nodules and lung cancers, including early‐stage cancers, than plain chest radiography 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 . In low‐dose CT for lung cancer screening (LDCT), the detection task is typically the observation of focal lung opacities or nodules.…”

Section: Introductionmentioning

confidence: 99%

A phantom study investigating the relationship between ground‐glass opacity visibility and physical detectability index in low‐dose chest computed tomography

Ichikawa

Kobayashi

Sagawa

et al. 2015

J Applied Clin Med Phys

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In this study, the relationship between ground‐glass opacity (GGO) visibility and physical detectability index in low‐dose computed tomography (LDCT) for lung cancer screening was investigated. An anthropomorphic chest phantom that included synthetic GGOs with CT numbers of ‐630 Hounsfield units (HU; high attenuation GGO: HGGO) and ‐800 HU (low attenuation GGO: LGGO), and three phantoms for physical measurements were employed. The phantoms were scanned using 12 CT systems located in 11 screening centers in Japan. The slice thicknesses and CT dose indices (CTDIvol) varied over 1.0–5.0 mm and 0.85–3.30 mGy, respectively, and several reconstruction kernels were used. Physical detectability index values were calculated from measurements of resolution, noise, and slice thickness properties for all image sets. Five radiologists and one thoracic surgeon, blind to one another's observations, evaluated GGO visibility using a five‐point scoring system. The physical detectability index correlated reasonably well with the GGO visibility (R2=0.709,p<0.01 for 6 mm HGGO and R2=0.646,p<0.01 for 10 mm LGGO), and was nearly proportional to the CTDIvol. Consequently, the CTDIvol also correlated reasonably well with the GGO visibility (R2=0.701,p<0.01 for 6 mm HGGO and R2=0.680,p<0.01 for 10 mm LGGO). As a result, the CTDIvol was nearly dominant in the GGO visibility for image sets with different reconstruction kernels and slice thicknesses, used in this study.PACS numbers: 81.70.Tx, 87.57.Q‐

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“…The use of LDCT for lung cancer screening programs has become more popular after publication of the results of the National Lung Cancer Screening Trial (NLST), which showed a 20% reduction in mortality rate among individuals monitored with the use of LDCT, compared to the group controlled by X-ray examination of the chest [2]. Many papers showing the results of clinical trials concerning early detection of lung cancer with the use of LDCT have been published to date [1][2][3][4][5][6][7][8][9][10]. Although we know many aspects of the use of LDCT as a tool to detect early lung cancer, there still remain many unanswered questions.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Selected Factors on the Attendance of the High-Risk Population in the Early Lung Cancer Detection Program

Zakrzewska

Szczepanowska

Książek

et al. 2013

Advances in Respiratory Medicine

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The influence of selected factors on the attendance of the high-risk population in the early lung cancer detection program Analiza czynników wpływających na zgłaszanie się osób zagrożonych zachorowaniem na raka płuca do programu wczesnego wykrywaniaThe authors declare no financial disclosure AbstractIntroduction. Lung cancer is the most common cause of cancer-related death worldwide, killing almost 22,000 people in Poland every year. Low-dose computed tomography (LDCT) is the most promising tool of secondary prophylaxis leading to early detection and thus successful treatment of this malignancy. Knowledge about socio-demographic factors that affect participation in lung cancer early detection programs is essential for the future design and implementation of such programs. Material and methods: Among the 8649 participants of the Pomeranian Lung Cancer Screening Program (PLCSP), 1619 individuals responded to a questionnaire that had been designed to assess socio-demographic data of participants at high risk of developing lung cancer. The survey was conducted on-site after reception of results by the program participants. Results: Among the survey participants, 777 (48%) were current cigarette smokers. The majority of them represented low or medium level of wealth status. The respondents positively evaluated the promotional campaign during the PLCSP, although 43% of them indicated family and friends as a source of information about the program. As the most important action that stimulated the participation, 46% of the respondents indicated the awareness campaign involving a celebrity, and 45% of them indicated the presence of cancer in the family. The influence of healthcare employees on the participation in the screening program was minimal. More than half of the respondents (53%) declared a willingness to co-finance a similar prophylactic program in the future in an amount not exceeding 100 PLN. Conclusions: An effective promotional campaign in the media, the influence of family and a campaign involving a celebrity promoted attendance at the screening program. The influence of healthcare employees on the participation in the program was minimal. The majority of the screened population declared a willingness to actively participate in the costs of LDCT examination. Materiał i metody:Badaniem objęto 1619 kolejnych osób z 8649, które zostały poddane LDCT w ramach Pomorskiego Pilotażo-wego Programu Badań Przesiewowych Raka Płuca (PPPBPRP). Badanie przeprowadzono z wykorzystaniem ankiety oceniającej dane społeczno-demograficzne uczestników należących do grupy wysokiego ryzyka zachorowania na raka płuca. Wyniki: Wśród uczestników PPPBPRP znalazło się 777 (48%) aktualnych palaczy tytoniu. Większość z nich reprezentowała niski lub średni stopień zamożności. Badani pozytywnie ocenili sposób przeprowadzenia kampanii promocyjnej programu, jednak 43% z nich wskazało rodzinę i znajomych jako równie ważne źródło uzyskiwania wiedzy o projekcie. Za główny bodziec skłaniający do brania udziału w podobnym programie 46% uczestnikó...

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Baseline results of the Depiscan study: A French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR)

Cited by 241 publications

References 41 publications

Lung Cancer Screening with CT

Lung Cancer Screening with CT

A phantom study investigating the relationship between ground‐glass opacity visibility and physical detectability index in low‐dose chest computed tomography

The Influence of Selected Factors on the Attendance of the High-Risk Population in the Early Lung Cancer Detection Program

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