Baseline oxidative defense and survival after 5–7 years among elderly stroke patients at nutritional risk: Follow-up of a randomized, nutritional intervention trial

Iversen, Per Ole; Ha, Lisa; Blomhoff, Rune; Hauge, Truls; Veierød, Marit B.

doi:10.1016/j.clnu.2014.07.002

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…detected a relationship between serum concentrations of total carotenoids and survival of ischemic stroke. [ 34 ] This cohort included 165 patients aged above 65 years admitted to hospital for acute stroke. The authors found that plasma levels above the median for total carotenoids were associated with reduced risk of death with adjusted hazard ratio of 0.29 (95% confidence interval [CI]: 0.12–0.71).…”

Section: Discussionmentioning

confidence: 99%

Carotenoids as potential antioxidant agents in stroke prevention: A systematic review

et al. 2017

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Stroke and other cerebrovascular diseases are among the most common causes of death worldwide. Prevention of modifiable risk factors is a cost-effective approach to decrease the risk of stroke. Oxidative stress is regarded as the major flexible operative agent in ischemic brain damage. This review presents recent scientific advances in understanding the role of carotenoids as antioxidants in lowering stroke risk based on observational studies. We searched Medline using the following terms: (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR “lycopene [Supplementary Concept]” [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR “Cerebrovascular Accident” [tiab] OR “Cerebrovascular Apoplexy” [tiab] OR “Brain Vascular Accident” [tiab] OR “Cerebrovascular Stroke” [tiab]) AND (“oxidative stress” [MeSH] OR “oxidative stress”[tiab]). This search considered papers that had been published between 2000 and 2017. Recent studies indicated that high dietary intake of six main carotenoids (i.e., lycopene, <- and®-carotene, lutein, zeaxanthin, and astaxanthin) was associated with reduced risk of stroke and other cardiovascular outcomes. However, the main mechanism of the action of these nutrients was not identified, and multiple mechanisms except antioxidant activity were suggested to be involved in the observed beneficial effects. The dietary intake of six major carotenoids should be promoted as this may have a substantial positive effect on stroke prevention and stroke mortality reduction.

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Section: Discussionmentioning

confidence: 99%

Carotenoids as potential antioxidant agents in stroke prevention: A systematic review

et al. 2017

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“…In the study that analyzed the body composition of this cohort of patients [365], the group that received the individualized nutritional treatment plan suffered less from unintentional weight loss in the first week of hospitalization, and the intervention subgroup of women had a smaller loss of body fat at 3 months, when compared with the control subgroup of women. The long term mortality (5e7 years post stroke) for this cohort was later analyzed [366] and results showed no statistically significant difference in this outcome between both groups. It should be noted that the nutritional intervention was delivered for a relatively short period of time (i.e.…”

Section: Recommendation 54mentioning

confidence: 99%

“…Another two papers from the same author and using the same cohort of patients were found [365,366]. In the study that analyzed the body composition of this cohort of patients [365], the group that received the individualized nutritional treatment plan suffered less from unintentional weight loss in the first week of hospitalization, and the intervention subgroup of women had a smaller loss of body fat at 3 months, when compared with the control subgroup of women.…”

Section: Recommendation 54mentioning

confidence: 99%

ESPEN guideline clinical nutrition in neurology

et al. 2018

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Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may be involved in the pathogenesis of neurological diseases. Multiple causes for the development of malnutrition in patients with neurological diseases are known including oropharyngeal dysphagia, impaired consciousness, perception deficits, cognitive dysfunction, and increased needs. The present evidence- and consensus-based guideline addresses clinical questions on best medical nutrition therapy in patients with neurological diseases. Among them, management of oropharyngeal dysphagia plays a pivotal role. The guideline has been written by a multidisciplinary team and offers 88 recommendations for use in clinical practice for amyotrophic lateral sclerosis, Parkinson's disease, stroke and multiple sclerosis.

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“…Literature data indicate that plasma carotenoids levels are reduced after stroke and are associated with infarct volume and the level of neurological deficits [ 29 , 30 ]. In a cohort study involving 165 post-stroke patients (age >65 years, 50.3% woman), it was shown that higher plasma carotenoids levels were associated with a lower risk of death from stroke (HR 0.29, 95% CI 0.12–0.71) [ 31 ]. Stroke-prone spontaneously hypertensive rat studies showed that β-carotene decreased fibroblast growth factor-1 (FGF1)-mediated gliosis of astrocytes by increasing the expression of genes related to cholesterol regulation: Abcg2, Abca1, Hmgcr, and Apoe [ 32 ].…”

Section: Natural Compoundsmentioning

confidence: 99%

The Role of Supplementation with Natural Compounds in Post-Stroke Patients

Cichoń

Saluk‐Bijak

Miller

et al. 2021

IJMS

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Malnutrition is a serious problem in post-stroke patients. Importantly, it intensifies with hospitalization, and is related to both somatic and psychological reasons, as well as is associated with the insufficient knowledge of people who accompany the patient. Malnutrition is a negative prognostic factor, leading to a reduction in the quality of life. Moreover, this condition significantly extends hospitalization time, increases the frequency of treatment in intensive care units, and negatively affects the effectiveness of rehabilitation. Obtaining growing data on the therapeutic effectiveness of new compounds of natural origin is possible through the use of pharmacodynamic and analytical methods to assess their therapeutic properties. The proper supply of nutrients, as well as compounds of natural origin, is an important element of post-stroke therapy, due to their strong antioxidant, anti-inflammatory, neuroprotective and neuroplasticity enhancing properties. Taking the above into account, in this review we present the current state of knowledge on the benefits of using selected substances of natural origin in patients after cerebral stroke.

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Baseline oxidative defense and survival after 5–7 years among elderly stroke patients at nutritional risk: Follow-up of a randomized, nutritional intervention trial

Cited by 7 publications

References 9 publications

Carotenoids as potential antioxidant agents in stroke prevention: A systematic review

Carotenoids as potential antioxidant agents in stroke prevention: A systematic review

ESPEN guideline clinical nutrition in neurology

The Role of Supplementation with Natural Compounds in Post-Stroke Patients

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