The Role of Supplementation with Natural Compounds in Post-Stroke Patients

Cichoń, Natalia; Saluk‐Bijak, Joanna; Miller, Elżbieta; Gorniak, Leslaw; Redlicka, Justyna; Niwald, Marta; Bijak, Michał

doi:10.3390/ijms22157893

Cited by 5 publications

(1 citation statement)

References 172 publications

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“…Complementary and alternative medicine (CAM), otherwise known as an unorthodox health approach, involves the use of nutritional, consisting of medicinal plants and herbs, phytochemicals, antioxidants, special diets, dietary supplements, probiotics, and microbial-based therapy; [157][158][159] physiological, including hypnosis, meditation, prayer/spirituality, music, and relaxation therapy; physical, comprising massage, acupuncture, and spinal manipulation; 160,161 and combination of physiological and physical approaches, such as dance, yoga, tai chi, and art therapy, or a variety of nutritional and physiological processes, such as mindful eating to treat and manage diseases and infections. 27,162 CAM is self-prescribed and administered by patients without the assistance of health care providers or physicians.…”

Section: Complementary and Alternative Medicine: Potential Elixirs Fo...mentioning

confidence: 99%

Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis

Arunsi

Chioma

Etusim

et al. 2022

Exp Biol Med (Maywood)

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Rheumatoid arthritis (RA) is a debilitating disease associated with locomotion impairment, and conventional therapeutic drugs are not optimal for managing RA. There is an avalanche of medications used for the management of RA. Still, studies have shown that they are associated with severe side effects, including hepatotoxicity, retinopathy, and cardiotoxicity disorders of the central nervous system (CNS), skin, blood, and infections. Complementary and alternative medicine (CAM) is currently gaining attention as a novel panacea for managing debilitating diseases, such as RA. Nigerian folk herbal remedies are replete with a plethora of curative medicine, albeit unvalidated scientifically but with seemingly miraculous provenance. Studies of the identification of bioactive compounds present in these botanicals using advanced spectral analytical techniques have enhanced our understanding of the role of Nigerian herbal remedies in the treatment and management of RA. Interestingly, experimental studies abound that the bioactive compounds present in the extracts of plant botanicals protected animals from the development of RA in different experimental models and reduced the toxicity associated with conventional therapeutics. Validated mechanisms of RA amelioration in human and animal models include suppression of the expression of NF-κB, IL-1β, TNF-α, IL-6, IL-8, IL-17, IL-23, chemokines, TGF-β, RANKL, RANK, iNOS, arginase, COX-2, VEGFA, VEGFR, NFATC1, and TRAP in the synoviocytes. Decreased ROS, NO, MDA, carbonyl groups, and PGE2 in the synovial fluid increased the expression of PPARα/γ; antioxidant and anti-inflammatory molecules also improve RA etiology. In this mini-review, we discuss the global burden of RA, the novel role of plant-based botanicals as potential therapeutics against signaling pathways in RA. Also addressed is the possible repurposing/reprofiling of plant botanicals to increase their therapeutic index among RA patients that patronize traditional healers in Nigeria with a global projection.

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