Baseline Nutritional Status Is Predictive of Response to Treatment and Survival in Patients Treated by Definitive Chemoradiotherapy for a Locally Advanced Esophageal Cancer

Fiore, Frédéric Di; Lecleire, Stéphane; Pop, Daniela; Rigal, Olivier; Hamidou, H.; Paillot, B; Ducrotté, Philippe; Lerebours, Éric; Michel, Pierre

doi:10.1111/j.1572-0241.2007.01437.x

Cited by 161 publications

(123 citation statements)

References 29 publications

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“…Undernutrition has been reported to be as frequent as 79% in patients with advanced esophageal cancer before starting treatment (31). In these patients, anorexia and dysphagia are the main factors involved in the onset of undernutrition (32). Basically, limitation of oral intake can be caused by tumor obstruction.…”

Section: Discussionmentioning

confidence: 99%

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Sato

Kunisaki

Suematsu

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Sato

Kunisaki

Suematsu

et al. 2018

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“…Malnutrition and inflammation suppress albumin synthesis (Yeun et al, 1998). In an adult the normal range of serum albumin is defined as 3.5-5.0 g/dL and levels <3.5 g/dL is called hypoalbuminemia (Di Fiore et al, 2007;Ishizuka et al, 2007). The inverse correlation between albumin synthesis and body weight index in cancer patients supports the possibility of a compensatory enhanced albumin synthesis in these metabolically affected patients.…”

Section: Discussionmentioning

confidence: 99%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

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“…A few reports that specifically focused on BMI suggested that pretreatment BMI was not associated with differential outcome with regard to OS or DFS. [12][13][14] However, the largest study to date is by Trivers et al 17 18 demonstrated that a BMI of >18 kg/m 2 was one of the independent prognostic factors in 105 patients treated with definitive chemoradiotherapy (P ¼ .003). However, in this study, the cutpoint for BMI was nontraditional and the sample size was small.…”

Section: Discussionmentioning

confidence: 99%

The influence of high body mass index on the prognosis of patients with esophageal cancer after surgery as primary therapy

Hayashi¹,

Correa²,

Hofstetter³

et al. 2010

Cancer

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BACKGROUND: High body mass index (BMI), a prevalent condition in the United States, is associated with esophageal adenocarcinoma (EAC). Its influence on a patient's outcome remains unclear. In the current study, the authors examined the impact of BMI on survival and complications in patients with esophageal cancer (EC) who underwent surgery as their primary therapy. METHODS: The authors retrospectively reviewed 301 consecutive EC patients who underwent surgery but received no adjunctive therapy. Patients were segregated into 2 subgroups based on their baseline BMI: normal/low (<25 kg/m 2 ) and high ( 25 kg/m 2 ). RESULTS: Seventy-six (25%) patients had a BMI <25 kg/m 2 and 225 (75%) patients had a BMI 25 kg/m 2 . In the high BMI group, there were more men (P < .001), fewer upper ECs (P ¼ .021), a lower baseline clinical stage (P ¼ .006), and frequent EAC (P < .001). Postoperative morbidity was similar in both groups, with the exception of gastrointestinal complications (P ¼ .016). The 5-year overall survival (OS) rates were 44% in the normal/low BMI group and 60% in the high BMI group (P ¼ .017). The 5-year disease-free survival (DFS) rates were 41% in the normal/low BMI group and 60% in the high BMI group (P ¼ .005). On multivariable analysis, age, weight loss, peripheral vascular disease (PVD), and both clinical and pathological stage of disease were found to be independent prognosticators for OS. Older age (hazard ratio [HR]

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Baseline Nutritional Status Is Predictive of Response to Treatment and Survival in Patients Treated by Definitive Chemoradiotherapy for a Locally Advanced Esophageal Cancer

Cited by 161 publications

References 29 publications

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

The influence of high body mass index on the prognosis of patients with esophageal cancer after surgery as primary therapy

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