Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects

Kaykhaei, Mahmoud Ali; Khodadoost, Mahdieh; Dashipour, Alireza; Haidari, Zahra; Karimkoshteh, Azra; Sandoughi, Mahnaz

doi:10.1007/s12020-019-01881-5

Cited by 6 publications

(8 citation statements)

References 45 publications

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“…Previously, a study on 114 vitamin D deficient subjects indicated an inverse relationship between baseline serum levels of 25(OH)D 3 and its increment following treatment with vitamin D 3 , based on weekly 50,000 IU dosing for 8 weeks 24 . Based on our dataset covering a wide dose range, we demonstrated that such inverse relationship existed when the graph was stratified by dosing duration, BMI, age, sex, season, and location (Figure 2b–i).…”

Section: Discussionmentioning

confidence: 99%

Personalise vitamin D₃ using physiologically based pharmacokinetic modelling

Huang¹,

You²

2021

CPT Pharmacom & Syst Pharma

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Section: Discussionmentioning

confidence: 99%

Personalise vitamin D₃ using physiologically based pharmacokinetic modelling

Huang¹,

You²

2021

CPT Pharmacom & Syst Pharma

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“…Baseline serum 25-OH-VitD level was previously highlighted as a probable factor affecting bioavailability of ingested vitamin D [ 19 ]. Kaykhaei et al recently showed this consistently using considerably higher dosages (1250 µg (50.000 IU) per week; 8 weeks) of cholecalciferol [ 33 ], while Williams also noted higher efficiency of Vitamin D3 absorption in subjects with lower baseline serum 25-OH-VitD levels [ 32 ]. Although in our study the interval of baseline serum 25-OH-VitD levels was quite narrow (due to selective inclusion of subjects with suboptimal vitamin D status), we observed that the magnitude of increase in serum 25-OH-VitD concentration is higher in subjects with lower baseline levels even in this narrow interval ( p = 0.0474, Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Efficiency of Vitamin D Supplementation in Healthy Adults is Associated with Body Mass Index and Baseline Serum 25-Hydroxyvitamin D Level

et al. 2020

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Vitamin D (VitD) has a critical role in phosphorous–calcium metabolism as well as an important role in the immune system. In the human body, VitD is synthesized as cholecalciferol in the skin, but this process requires sunlight (UVB) radiation. Numerous reports showed high prevalence of VitD deficiency, particularly during the winter season, indicating the importance of VitD supplementation. Various factors can affect the absorption of VitD, including dosage and formulation. The primary study objective was to examine the efficiency of supplementation with three different formulations containing cholecalciferol in comparison with the control group. The secondary objective was to identify other factors affecting increase in serum 25-OH-VitD. A randomized controlled intervention study was conducted in Slovenia during wintertime (January– March) on 105 apparently healthy subjects (aged 18–65 years) with suboptimal VitD status (25-OH-VitD 30–50 nmol/L). Subjects were randomized into four groups: three treatment groups receiving (A) capsules with starch-adsorbed VitD, (B) oil-based Valens VitD oral spray, or (C) water-based Valens VitD oral spray and a control group (D) which did not receive supplemental VitD. Two months of supplementation with cholecalciferol (1000 IU; 25 µg daily) resulted in significant increase in serum 25-OH-VitD levels in comparison with control group (pooled Δc 32.8 nmol/L; 95% CI: 23.0, 42.5, p < 0.0001). While we did not observe any significant differences between the tested formulations, the efficiency of supplementation was associated with body mass index and baseline serum 25-OH-VitD level. Higher supplementation efficiency was observed in participants with normal body weight (BMI < 25) and in those with more pronounced VitD insufficiency. We also determined that tested dosage was not sufficient to achieve recommended 25-OH-VitD levels in all subjects.

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“…Drincic and colleagues reported that 2.5 U/kg VitD is needed to increase 25(OH)D level in serum by as much as 1 ng/ml (Drincic et al, 2013). Recently, Kaykhaei observed that the increase in VitD levels were 26.4, 18.5, and 8.3 ng/ml, in participants with baseline VitD concentrations below 10, 10–20, and 20–30 ng/ml, respectively (Kaykhaei et al, 2019). Because hepatic hydroxylation of VitD is possibly a saturable trend, response to VitD supplementation may be influenced via baseline 25(OH)D levels (Barger-Lux et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks

et al. 2020

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Background: Vitamin D has recently attracted interest for its pleiotropic effects. Vitamin D supplements are a potentially important public health intervention, but the response to supplementation varies between individuals. Aim: We aimed to assess the association between several neuropsychological parameters and the magnitude of response to vitamin D supplementation using an artificial neural network method. Methods: Neuropsychological function was assessed in 619 participants using standard questionnaires. The study participants received vitamin D capsules containing 50,000 IU vitamin D per week over 9 weeks. To assess the relationship between responsiveness to vitamin D supplements and the impact on these neuropsychological parameters, the best-performing artificial neural network algorithms were selected from a combination of different transfer functions in hidden and output layers and variable numbers of hidden layers (between two and 50). The performance of the artificial neural network algorithm was assessed by receiver operating characteristic analysis and variables of importance were identified. Results: The artificial neural network algorithm with sigmoid transfer function in both hidden and output layers could predict responsiveness to vitamin D supplementation effectively. The sensitivity and specificity were between 0.60 and 0.70 and 0.66 and 0.70, respectively. Cognitive abilities (42.5%), basal vitamin D (21.3%), body mass index (9.5%), and daytime sleepiness (8%) are the most widely used variables to predict changes in serum vitamin D levels. Conclusions: Cognitive abilities status and baseline 25-hydroxyvitamin D are important novel modifiers of the enhancement in circulating 25-hydroxyvitamin D after vitamin D supplementation.

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Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects

Cited by 6 publications

References 45 publications

Personalise vitamin D₃ using physiologically based pharmacokinetic modelling

Personalise vitamin D₃ using physiologically based pharmacokinetic modelling

Efficiency of Vitamin D Supplementation in Healthy Adults is Associated with Body Mass Index and Baseline Serum 25-Hydroxyvitamin D Level

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks

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Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects

Cited by 6 publications

References 45 publications

Personalise vitamin D3 using physiologically based pharmacokinetic modelling

Personalise vitamin D3 using physiologically based pharmacokinetic modelling

Efficiency of Vitamin D Supplementation in Healthy Adults is Associated with Body Mass Index and Baseline Serum 25-Hydroxyvitamin D Level

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks

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Personalise vitamin D₃ using physiologically based pharmacokinetic modelling

Personalise vitamin D₃ using physiologically based pharmacokinetic modelling