Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey

Kartı, Ömer; Karti, Dilek Top; Kılıç, İlay Hilal; Gökçay, Figen; Çelebisoy, Neşe

doi:10.1007/s10792-017-0799-5

Cited by 4 publications

(10 citation statements)

References 52 publications

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“…4 , 32 – 34 A study in Turkey revealed that idiopathic-ON and MS were the most frequent etiologies, whereas NMOSD was the least frequent etiology. 35 These studies suggest that the frequency of ON etiologies varies among patients of different ethnic backgrounds. Early recognition of the specific cause of ON is important to prevent severe visual loss and avoid inappropriate treatments.…”

Section: Discussionmentioning

confidence: 99%

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

Vanikieti

Janyaprasert

Lueangram

et al. 2020

OPTH

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Purpose: To analyze the demographic patterns, clinical characteristics and etiologies of acute optic neuritis (ON). Methods: This retrospective observational study included patients with acute ON who presented to a university hospital in Bangkok, Thailand, between January 2010 and March 2020. The demographic details, clinical characteristics and etiologies of acute ON were evaluated. Results: A total of 171 patients were included in the study (78.4% [n=134] female; mean age 45 years [standard deviation 15.4 years]; 32.2% [n=55] bilateral involvement). The most common type of acute ON was idiopathic (51.5%), followed by neuromyelitis optica spectrum disorder (NMOSD, 30.9%), other autoimmune disorders (9.9%), myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD, 5.3%), multiple sclerosis (MS, 1.8%), and postinfection (0.6%). In the other autoimmune disorders group, 2 patients developed systemic lupus erythematosus (1.2%), 2 Sjogren's syndrome (1.2%), 1 RA (0.6%), 1 anti-NMDAR (0.6%), 3 anti-Jo1 (1.8%), 2 c-ANCA (1.2%), 1 anti-centromere (0.6%), and 5 nonspecific autoimmune disorders (2.9%). In the idiopathic group, 38.6% developed single isolated ON, 1.8% relapsing isolated ON and 11.1% chronic relapsing inflammatory optic neuropathy. Conclusion: The most common form of acute ON in this study, similar to other Asian countries, was idiopathic. Idiopathic-ON shared some phenotypes with NMOSD and MOGAD. We also reported patients with anti-NMDAR, anti-Jo1, c-ANCA and anti-centromere disorders. Improvements in antibody detection have widened the range of possible etiologies of acute ON. The study highlighted the important role of antibodies in creating effective treatments in the future.

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Section: Discussionmentioning

confidence: 99%

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

Vanikieti

Janyaprasert

Lueangram

et al. 2020

OPTH

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“…Although previous studies didn't prove any effective role but later on researchers found out that it is effective if given early 20 . Karti et al 9 , showed a promising role of steroids in cases of ischemic, MS related and NMOSD related ON however few authors didn't agree 21,22 .…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, literature search using pubmed and other search engines the subject topic is scarcely studied. Dhiman et al 8 , and Karti et al 9 , studied it in Indian and Turkish population respectively. However no such study is done so far in Pakistani population.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Optic Neuropathies Presenting in Neuroophthalmology Clinic at Afio

Ijaz

Habib

Rathore

et al. 2021

PAFMJ

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Objective: To study the spectrum of optic neuropathies in patient’s presenting at AFIO Rawalpindi. Study Design: Descriptive study/retrospective study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi, from Jan 2017 to Dec 2017. Methodology: Retrospective analysis of hospital record of patients coming to neuro-ophthalmic clinic of ArmedForces Institute of Ophthalmology (AFIO), Rawalpindi, from Jan to Dec 2017 was done. Only patients with clearfinal diagnosis of neurophthalmic disease were included. Those with vague diagnosis were excluded. Data wasentered in SPSS version 22 and grouped into variables before analysis. Chi-square test was used for statisticalanalysis. The p<0.05 was considered significant. Results: Forty-five patients were included in study including 33 (73.3%) males and 12 (26.6%) females. Mean age of patients was 41.64 ± 17.74 years. Patients were grouped into ischemic optic neuropathy 20%, toxic optic neuropathies 20%, compressive optic neuropathies 17.7%, inflammatory optic neuropathies 11%, neuroretinitis 6.7%, hereditary optic neuropathies 6.7%, multiple sclerosis (MS) related 4.4%, neuromylitis optics spectrum (NMO-SD) related 4.4%, traumatic optic neuropathies 4.4% and nutritional optic neuropathies 4.4%. Deficiency of vitamin B12 and vitamin D was strongly associated with nutritional optic neuropathies while raised TLC was most common association with inflammatory optic neuropathies (57.14%) and of neuroretinitis (66%). Anti-tuberculosis drugs were most common cause of toxic optic neuropathies (88.88%). Chi square test was used for statistical analysis and p<0.05 was considered significant. Conclusion: Ischemic optic neuropathy is the most common presentation in our population according to ourstudy. However...........

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“…Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acquired primary optic neuropathy in individuals over the age of 50. 1 Factors which predispose certain eyes to develop NAION have been recognized. The primary risk factor for NAION appears to be a small-crowded optic disc.…”

Section: Introductionmentioning

confidence: 99%

“…Suggested additional identified factors associated with NAION include atherosclerotic vascular disease, diabetes mellitus, hypertension, hyperlipidemia, obesity and use of specific medications such as phosphodiesterase 5 inhibitors. [1][2][3][4] It has been suggested that NAION arise as a consequence of the obstruction of the axoplasmic flow due to the ischemia. NAION has been reported in cases, some relatively young, with optic nerve head drusen (ONHD).…”

Section: Introductionmentioning

confidence: 99%

Acute Unilateral Anterior Ischemic Optic Neuropathy Secondary to Optic Nerve Head Drusen: Report of a Rare Coexistence

Kartı

Karti

Zengin

et al. 2018

Neuro-Ophthalmology

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A 45-year-old white male noticed on awakening the painless loss of inferior vision in the left eye 2 days ago. He was otherwise well and his medical history was unremarkable. Visual acuity was 20/20 in OD and 20/32 in OS with a left inferior altitudinal defect and right blind spot enlargement demonstrable on visual field test. On fundus examination, both disc margins were blurred and the left disc was diffusely oedematous, with linear haemorrhages in the adjacent nerve fibre layer. Radiologic imaging and laboratory tests were unremarkable. Bilateral optic nerve head drusen (ONHD) was demonstrated by optical coherence tomography and fundus autofluorescence imaging. Unilateral acute non-arteritic anterior ischemic optic neuropathy (NAION) and concomitant bilateral ONHD were diagnosed. NAION may develop secondary to ONHD. Therefore, clinicians should be aware of this rare association and inform the patients about this risk. Patients with ONHD should be followed-up periodically in terms of possible ischemic complications.

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Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey

Cited by 4 publications

References 52 publications

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

Spectrum of Optic Neuropathies Presenting in Neuroophthalmology Clinic at Afio

Acute Unilateral Anterior Ischemic Optic Neuropathy Secondary to Optic Nerve Head Drusen: Report of a Rare Coexistence

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