Baseline circulating ghrelin does not predict weight regain neither maintenance of weight loss after gastric bypass at long term

Pellitero, Sílvia; Pérez-Romero, Noelia; Martínez, Eva; Granada, María Luisa; Moreno, Pau; Tarascó, Jordi; Lucas, Anna; Puig-Domingo, Manel

doi:10.1016/j.amjsurg.2014.08.040

Cited by 15 publications

(5 citation statements)

References 34 publications

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“…Our study is in accordance with studies that found no significant changes in ghrelin following RYGB . A recent study that followed RYGB patients for six years found that leptin, insulin and ghrelin at baseline or their changes over time did not predict long‐term excess weight loss . The authors found significantly higher ghrelin levels and significantly lower leptin and insulin levels at 12 months compared to baseline, but no significant changes were found between 12 and 24 months.…”

Section: Discussionsupporting

confidence: 91%

“…[14][15][16] A recent study that followed RYGB patients for six years found that leptin, insulin and ghrelin at baseline or their changes over time did not predict long-term excess weight loss. 17 The authors found significantly higher ghrelin levels and significantly lower leptin and insulin levels at 12 months compared to baseline, but no significant changes were found between 12 and 24 months. An intact vagal nerve is required for the appetite-stimulating effect of ghrelin, 18 and the variability of data among ghrelin studies could be attributed to the degree of vagal dysfunction.…”

Section: Discussionmentioning

confidence: 92%

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Changes in metabolic hormones after bariatric surgery and their predictive impact on weight loss

Kruljac

Mirošević

Kirigin

et al. 2016

Clinical Endocrinology

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 92%

Changes in metabolic hormones after bariatric surgery and their predictive impact on weight loss

Kruljac

Mirošević

Kirigin

et al. 2016

Clinical Endocrinology

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“…Gender and age: Male gender is also significantly associated with suboptimal weight loss in studies, even after possible adjustment ( 29 , 46 , 58 ); however, numerous cultural factors might confound this association ( 9 ). Age as an RF remains controversial; therefore, some studies have declared old age (age > 60 years) as an RF for IWL and WR post-BMS; nevertheless, some studies have introduced young age as an RF ( 56 , 57 ).…”

Section: Resultsmentioning

confidence: 99%

What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery

Zefreh,

Amani-Beni,

Sheikhbahaei

et al. 2023

Int J Endocrinol Metab

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Context: This review study aimed to investigate the definition, etiology, risk factors (RFs), management strategy, and prevention of insufficient weight loss (IWL) and weight regain (WR) following bariatric metabolic surgery (BMS). Evidence Acquisition: Electronic databases were searched to retrieve relevant articles. The inclusion criteria were English articles with adult participants assessing the definition, prevalence, etiology, RFs, management strategy, and prevention of IWL/WR. Results: Definition: The preferred definition for post-BMS IWL/WR are the terms "Lack of maintenance of total weight loss (TWL)>20%" and "weight change in percentage compared to nadir weight or weight loss". Prevalence: The exact prevalence of IWL/WR is still being determined due to the type of BMS and various definitions. Etiology: Several mechanisms, including hormonal/metabolic, dietary non-adherence, physical inactivity, mental health, and anatomic surgical failure, are possible etiologies of post-BMS IWL/WR. RFs: Preoperative body mass index (BMI), male gender, psychiatric conditions, comorbidities, age, poor diet, eating disorders, poor follow-ups, insufficient physical activity, micronutrients, and genetic-epigenetic factors are the most important RFs. Management Strategy: The basis of treatment is lifestyle interventions, including dietary, physical activity, psychological, and behavioral therapy. Pharmacotherapy can be added. In the last treatment line, different techniques of endoscopic surgery and revisional surgery can be used. Prevention: Behavioral and psychotherapeutic interventions, dietary therapy, and physical activity therapy are the essential components of prevention. Conclusions: Many definitions exist for WR, less so for IWL. Etiologies and RFs are complex and multifactorial; therefore, the management and prevention strategy is multidisciplinary. Some knowledge gaps, especially for IWL, exist, and these gaps must be filled to strengthen the evidence used to guide patient counseling, selection, and improved outcomes.

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“…Bariatric surgery was demonstrated to achieve favorable outcomes in both women and men. Few studies found that there is a difference in postsurgical weight regain between the two groups, and those studies pointed towards different directions [ 29 , 30 , 55 ].…”

Section: Predictors Of Success In Bariatric Surgerymentioning

confidence: 99%

Towards precision medicine in bariatric surgery prescription

Pereira

Guimarães

Monteiro

2023

Rev Endocr Metab Disord

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Obesity is a complex, multifactorial and chronic disease. Bariatric surgery is a safe and effective treatment intervention for obesity and obesity-related diseases. However, weight loss after surgery can be highly heterogeneous and is not entirely predictable, particularly in the long-term after intervention. In this review, we present and discuss the available data on patient-related and procedure-related factors that were previously appointed as putative predictors of bariatric surgery outcomes. In addition, we present a critical appraisal of the available evidence on which factors could be taken into account when recommending and deciding which bariatric procedure to perform. Several patient-related features were identified as having a potential impact on weight loss after bariatric surgery, including age, gender, anthropometrics, obesity co-morbidities, eating behavior, genetic background, circulating biomarkers (microRNAs, metabolites and hormones), psychological and socioeconomic factors. However, none of these factors are sufficiently robust to be used as predictive factors. Overall, there is no doubt that before we long for precision medicine, there is the unmet need for a better understanding of the socio-biological drivers of weight gain, weight loss failure and weight-regain after bariatric interventions. Machine learning models targeting preoperative factors and effectiveness measurements of specific bariatric surgery interventions, would enable a more precise identification of the causal links between determinants of weight gain and weight loss. Artificial intelligence algorithms to be used in clinical practice to predict the response to bariatric surgery interventions could then be created, which would ultimately allow to move forward into precision medicine in bariatric surgery prescription.

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Baseline circulating ghrelin does not predict weight regain neither maintenance of weight loss after gastric bypass at long term

Cited by 15 publications

References 34 publications

Changes in metabolic hormones after bariatric surgery and their predictive impact on weight loss

Changes in metabolic hormones after bariatric surgery and their predictive impact on weight loss

What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery

Towards precision medicine in bariatric surgery prescription

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