Changes in metabolic hormones after bariatric surgery and their predictive impact on weight loss

Kruljac, Ivan; Mirošević, Gorana; Kirigin, Lora Stanka; Nikolić, Marko; Ljubičić, Neven; Budimir, Ivan; Bešlin, Miroslav Bekavac; Vrkljan, Milan

doi:10.1111/cen.13160

Cited by 17 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The sample size of these trials ranged from 10 to 245 patients. Fourteen trials were nonrandomized, prospective observational studies, [16,19,22–25,27,28,33,37,39,41,45,47] 18 were retrospective cohort studies, [17,18,20,21,26,29–32,34–36,38,40,42–44,46] and 1 was a prospective RCT. [48] The improvement or remission of diabetes and hypertension is recorded in different follow-up periods, and all patients were followed for less than 4 years.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the effectiveness of laparoscopic adjustable gastric banding versus laparoscopic sleeve gastrectomy for obesity

Yu²,

Liang

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the effectiveness of laparoscopic adjustable gastric banding versus laparoscopic sleeve gastrectomy for obesity

Yu²,

Liang

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

“…It is also characterized as a state of low GH function resulting from blunted GH secretion or increased GH clearance [ 14 , 15 ]. Significant weight loss not only improves glycemic control and fatty liver disease [ 16 , 17 ] but is also accompanied by an amelioration or restoration of GH metabolism [ 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic effects of reduced growth hormone action in fatty liver disease

et al. 2018

View full text Add to dashboard Cite

BackgroundAdult growth hormone (GH) deficiency is associated with fatty liver disease and shows several features of the metabolic syndrome. Vice versa obesity is characterized as a state of low GH function. Here, we aimed to define the role of hepatic GH signaling and its metabolic consequences in non-alcoholic fatty liver disease.MethodsIn humans, GHR and IGF-1 levels were determined in liver samples of 29 obese patients with non-alcoholic steatohepatitis (NASH) or simple steatosis. Cellular effects of GH on insulin signaling were investigated in GH receptor (GHR) knockdown HepG2 cells.ResultsHepatic IGF-1 expression levels reflecting GH action were significantly lower and fasting glucose concentrations higher in patients with NASH than in patients with simple steatosis. GHR knockdown in hepatocytes resulted in a scenario of high glucose output displayed by reduced glycogen content, increased gluconeogenesis and diminished insulin signaling.ConclusionsOur data suggest that GH signaling in the liver is diminished in patients with NASH and associated with deteriorated hepatic insulin sensitivity and metabolic activity. Reduced hepatic GH action might contribute to insulin resistance in obese patients with NASH.

show abstract

“…The mechanisms of TSH decrease after bariatric surgery remain incompletely understood and remain to be further elucidated. One of the most plausible explanations is the decrease of leptin levels following bariatric surgery [31]. With decreasing amount of body fat, the decreasing leptin circulating levels [32] reduce the central stimulation of the thyroid axis [29,30] and promote a decrease of TSH.…”

Section: Discussionmentioning

confidence: 99%

Effect of Weight Loss after Bariatric Surgery on Thyroid-Stimulating Hormone Levels in Patients with Morbid Obesity and Normal Thyroid Function

et al. 2017

View full text Add to dashboard Cite

Background Several studies have reported that morbid obesity is associated with increased thyroid-stimulating hormone (TSH) levels. However, it is not clear what is the impact of bariatric surgery on postoperative thyroid function. The aim of this study was to evaluate the effect of weight loss after bariatric surgery on TSH levels in euthyroid patients with morbid obesity. TSH, free thyroxine (FT4), free triiodothyronine (FT3), type of surgery, and excessive body weight loss (EBWL) on TSH variation 12 months after surgery was evaluated. MethodsResults The high-normal TSH group (24.3% of patients) included more women, presented a higher BMI, higher systolic blood pressure, and higher FT3 levels. There was a significant decrease of TSH 12 months after surgery that was more marked in the high-normal TSH group (normal TSH group: 1.57 ± 0.49 to 1.53 ± 0.69 mIU/L, p = 0.063; high-normal TSH group: 3.23 ± 0.59 to 2.38 ± 0.86 mIU/L, p < 0.001). In a multivariate analysis, after adjusting for relevant covariates, EBWL, baseline BMI, and baseline FT3 were significantly associated with TSH decrease 12 months after bariatric surgery.Conclusion Bariatric surgery promotes a decrease of TSH that is significantly greater in patients with high-normal TSH and is independently associated with EBWL after surgery.

show abstract

Changes in metabolic hormones after bariatric surgery and their predictive impact on weight loss

Cited by 17 publications

References 22 publications

Meta-analysis of the effectiveness of laparoscopic adjustable gastric banding versus laparoscopic sleeve gastrectomy for obesity

Meta-analysis of the effectiveness of laparoscopic adjustable gastric banding versus laparoscopic sleeve gastrectomy for obesity

Metabolic effects of reduced growth hormone action in fatty liver disease

Effect of Weight Loss after Bariatric Surgery on Thyroid-Stimulating Hormone Levels in Patients with Morbid Obesity and Normal Thyroid Function

Contact Info

Product

Resources

About