Basaloid squamous cell carcinoma: Report of five cases

Abstract

Objectives: To document the clinical and histopathological characteristics of basaloid squamous cell carcinoma (BSCC). To add five new cases to the literature and compare them with another published series. Cases: retrospective review of five cases with the diagnosis of BSCC of the larynx. Results: all the patients were male. They were heavy smokers and drinkers. Most of the tumours were supraglottic. Three patients presented with stage-IV disease and the other two with stage-I disease. Surgery supplemented with radiation was used in three patients, partial surgery was used in another case and radiation and associated chemotherapy in the other one. Eight neck dissections were performed, six of them were functional and the other two radical dissections. Two cases were found to have metastatic lymph nodes. There were not any distant metastases but two patients had tumoral relapse. Conclusions: BSCC has well defined histological features. Central comedonecrosis within the cells nests, cell with nuclear palisading and high-grade dysplasia in overlaying mucosa are the main characteristics.

Basaloid squamous cell carcinoma of the esophagus

“…BSCC is an uncommon but distinctive neoplasm that most often occurs in the upper aerodigestive tract, especially the hypopharynx, larynx, and base of the tongue (Wang et al 2011;Morales-Puebla et al 2010). Considering the recent recognition of this tumor, the true incidence of BSCC in the esophagus is still uncertain.…”

Basaloid squamous cell carcinoma of uterine cervix in a young adult - A case report

“…Single cases at a younger age were also described. 2,6 The basaloid carcinoma has different locations: laryngopharynx, the base of the tongue, salivary glands, oesophagus, anal canal, prostate, thymus, vulva, and urinary bladder. The finding of involvement of the uterine cervix is exceptionally rare.…”

Basaloid Squamous Cell Carcinoma and Petrous Bone

“…comedonecrosis areas can be seen in the center of the neoplastic lobules and is also possible to see smaller glandlike spaces filled with mucin or hyalinized material. Furthermore, foci of squamous differentiation or conventional SCC may be found (1,3). Immunohistochemical studies are very helpful for diagnosis.…”