Basaloid Squamous Cell Carcinoma of the Larynx: A Report of Four New Cases

Erişen, Levent; Çoşkun, Hakan; Özuysal, Sema; Basut, Oğuz; Onart, Selçuk; Hizalan, Ibrahim; Tezel, Ilker

doi:10.1097/00005537-200407000-00009

Cited by 42 publications

(23 citation statements)

References 21 publications

(59 reference statements)

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“…Winzenburg et al [35] showed significant differences in survival of BSCC with and without lymph node metastases, with survivals of 18.6 and 47.6 months respectively, and our experience confirms it. Distant metastases do also occur in BSCCs with wide numbers ranging from 10% [4,36] to around 50% [1,2,37] or even to 75% [38]. We found them in 15% of our patients.…”

Section: Discussionsupporting

confidence: 60%

Basaloid Squamous Cell Carcinoma of the Head and Neck

Ereño

Gaafar

Oiarbide

et al. 2008

Head and Neck Pathol

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Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of cancer that mainly arises in the upper aerodigestive tract. This study reviews the clinico-pathological features and follow-up of a series of cases occurring in the head and neck. During a 32-year period (1974-2005), a total of 40 BSCCs have been diagnosed in the head and neck in our Institution. Males predominated in the series (35M/5F). The average age was 60.2 years (range, 40-85). Tobacco and alcohol consumption was found in more than 80% of the cases. Topographic distribution was as follows: larynx and hypopharynx, 22 cases (55%); oropharynx, 12 cases (30%); and oral cavity 6 cases (15%). The basaloid component predominated in 29 cases (72.5%). Vasculo-lymphatic invasion was detected in 5 cases (12.5%). Lymph node metastases were seen in 25 cases (62.5%, levels II and III in the neck dissection). Local recurrences appeared in 11 cases (27.5%) and distant metastases in 6 (15%). In 7 cases (17.5%) a second primary tumour was detected. The 2002 TNM staging was as follows: Stage I, 5 cases (12.5%); Stage II, 7 cases (17.5%); Stage III, 8 cases (20%), and Stage IV, 20 cases (50%). On follow-up, 21 cases (52.5%) are alive and 19 (47.5%) died of disease. Three- and 5-year overall survival was 50% and 38.5%, respectively. A significant shorter survival was detected in node positive patients (P<0.05).

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Section: Discussionsupporting

confidence: 60%

Basaloid Squamous Cell Carcinoma of the Head and Neck

Ereño

Gaafar

Oiarbide

et al. 2008

Head and Neck Pathol

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“…The numbers of patients with BSCC in these studies ranged from 4 to 49 (median, 10 patients). Eleven of these studies suggest that patients with BSCC have a worse prognosis, 1,2,10,11,13,15,18,20,[24][25][26] whereas the remaining studies either suggest that the behavior of BSCC is not different from SCC, 5,12,14,16,17,[21][22][23]27,28 or did not address the issue of comparative prognosis. 19,29 The common factor suggesting that BSCC has a worse prognosis in these studies has been the pro- pensity for BSCC to present in advanced stages and to have higher rates of hematogenous spread.…”

Section: Discussionmentioning

confidence: 99%

Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck

Thariat

Ahamad

El‐Naggar

et al. 2008

Cancer

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BACKGROUND.Basaloid squamous cell carcinoma (BSCC) is an uncommon, high‐grade variant of squamous cell carcinoma (SCC) of the head and neck. Its poorer prognosis compared with common SCC remains controversial. The authors investigated the outcomes of patients with BSCC who received radiotherapy and compared them with the outcomes of patients with SCC.METHODS.From 1994 to 2004, 1007 patients received radiotherapy for head and neck carcinoma with lymph node involvement. The histologic types consisted of 51 BSCC, 431 poorly differentiated SCC (PSCC), and 525 well or moderately differentiated SCC (WMSCC). A case–control analysis was performed with BSCC matched against both PSCC and WMSCC to compare disease‐control and survival rates.RESULTS.Patients with BSCC received treatment modalities similar to those received by patients with SCC: They received induction chemotherapy (12%) or concurrent chemotherapy (33%), and a median radiation dose of 70 Gray. Posttreatment viable tumor was present in 44%, 13%, and 28% of neck dissection specimens from patients with BSCC, PSCC, and WMSCC, respectively. The 5‐year disease‐free survival rates (63%, 77%, and 76%, respectively) and overall survival rates (85%, 70%, and 71%, respectively) demonstrated no statistically significant differences for BSCC, PSCC, or WMSCC, respectively.CONCLUSIONS.In this study, a poorer prognosis could not be demonstrated for irradiated patients with BSCC compared with either PSCC or WMSCC. All patients in this study had positive lymph node status, and the majority of patients (84%) had oropharyngeal cancer. The BSCC cohort did have a relatively high rate of viable tumor in their posttreatment neck dissections, and they had a relatively high rate of distant disease. On the basis of the high rate of lung metastases and the possibility of efficient salvage, the authors recommend obtaining a chest computed tomography scan during initial staging and follow‐up. Cancer 2008. © 2008 American Cancer Society.

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“…In their study the 5 year survival is estimated to be 17,5% and metastases (regional and/or distant) were found in 86,67% of their cases (6). Others studies, that present cases diagnosed in an early stage of the disease, show similar prognosis to the classic squamous cell carcinoma (3,5,10,14). However, due to their presentation in advanced stages the global prognosis of this type of tumor tends to be poorer.…”

Section: Dicussionmentioning

confidence: 93%

Basaloid squamous cell carcinoma: Report of five cases

Puebla¹,

Toro-Rojas²,

Segura-Saint-Gerons³

et al. 2010

Med Oral

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Objectives: To document the clinical and histopathological characteristics of basaloid squamous cell carcinoma (BSCC). To add five new cases to the literature and compare them with another published series. Cases: retrospective review of five cases with the diagnosis of BSCC of the larynx. Results: all the patients were male. They were heavy smokers and drinkers. Most of the tumours were supraglottic. Three patients presented with stage-IV disease and the other two with stage-I disease. Surgery supplemented with radiation was used in three patients, partial surgery was used in another case and radiation and associated chemotherapy in the other one. Eight neck dissections were performed, six of them were functional and the other two radical dissections. Two cases were found to have metastatic lymph nodes. There were not any distant metastases but two patients had tumoral relapse. Conclusions: BSCC has well defined histological features. Central comedonecrosis within the cells nests, cell with nuclear palisading and high-grade dysplasia in overlaying mucosa are the main characteristics.

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Basaloid Squamous Cell Carcinoma of the Larynx: A Report of Four New Cases

Abstract: In contrast with the literature reporting the tendency of more aggressive clinical behavior of the BSCC, we can say that BSCC has a behavior similar to conventional squamous cell carcinoma based on our 4 cases.

Cited by 42 publications

References 21 publications

Basaloid Squamous Cell Carcinoma of the Head and Neck

Basaloid Squamous Cell Carcinoma of the Head and Neck

Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck

Basaloid squamous cell carcinoma: Report of five cases

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