Basaloid squamous cell carcinoma of the maxilla

Wedenberg, Cecilia; Jesslén, Per; Lundqvist, Gerd; Lundgren, Jan T.; Hellquist, Henrik

doi:10.1016/s0964-1955(96)00063-2

Cited by 23 publications

(20 citation statements)

References 25 publications

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“…[14]), oral mucosa and maxillary tuberosity (C. Wedenberg et al . [15]), floor of the mouth (Kunal Sah et al . [16]), retromolar trigone (Marcia Sampaio Campose et al .…”

Section: Case Reportmentioning

confidence: 99%

Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature

Rachel

Kumar

Jain

2011

J Oral Maxillofac Pathol

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Basaloid squamous cell carcinoma (BSCC) is a rare distinct histologic variant of squamous - cell carcinoma of the head and neck region. BSCC is more aggressive and has a poorer prognosis, although histologically, it is associated with squamous cell carcinoma and squamous atypia. The usual site of occurrence for BSCC is the upper aerodigestive tract, floor of the mouth and base of the tongue. This is a case report of an unusual case of BSCC of retromolar trigone, which is quite rare.

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“…[14]), oral mucosa and maxillary tuberosity (C. Wedenberg et al . [15]), floor of the mouth (Kunal Sah et al . [16]), retromolar trigone (Marcia Sampaio Campose et al .…”

Section: Case Reportmentioning

confidence: 99%

Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature

Rachel

Kumar

Jain

2011

J Oral Maxillofac Pathol

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“…Additionally, distinguishing AM‐BC from other variants of AM is of paramount importance (Sridhar et al, ). Many scholars believe that pathologists can make a confirmatory diagnosis of lesions with histological perplexity by immunohistochemical (IHC) analysis, such as the analysis of Ber‐EP4, CD117, cytokeratins (CKs), p53, and epithelial membrane antigen (Emanuel, Wang, Wu, & Burstein, ; Ide et al, ; Del Rosario, Barr, Jensen, & Cantos, ; Wedenberg, Jesslen, Lundqvist, Lundgren, & Hellquist, ). Several mutations in oncogenes, such as cysteine‐rich protein with Kazal motifs ( RECK ), B‐type Raf kinase ( BRAF ), smoothened ( SMO ), and rat sarcoma ( Ras ) genes, have been reported in AM; of these, the BRAF mutation is the most frequent (Heikinheimo, Kurppa, & Elenius, ; Kumamoto, Izutsu, Ohki, Takahashi, & Ooya, ; Kumamoto, Takahashi, & Ooya, ; Sweeney et al, ; Zhang, Wang, Liu, Zhang, & Dong, ).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic study on a rare variant of ameloblastoma with basal cell features

et al. 2019

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Objectives: To investigate the clinical features, pathologic manifestations, and biologic behaviors of a variant of ameloblastoma with basal cell features (AM-BC). Materials and methods: Following retrospective review of the clinical and pathological data of six cases of AM-BC, we described their histological and immunohistochemical (IHC) features and discussed the biologic behaviors, prognoses, pathogenesis, and clinical relevance of AM-BC. Direct sequencing of polymerase chain reaction products was also performed in all cases. Results: The six cases of AM-BC involved four women and two men, aged 22-82 years. Four lesions occurred in the maxilla and two in the mandible. Histologically, the basal cells tended to be arranged as unequally sized follicles, strands, or cords of odontogenic epithelium in the connective tissue stroma. Little or no stellate reticulum was present in the central portion of the nest. Expression of CKs was consistent with other histological variants of ameloblastoma (AM), but AM-BC had significantly higher p53 and Ki-67 (p < 0.05) labeling indices than other histological variants of AM. Two patients had BRAF gene mutations.

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“…BSCC is particularly uncommon in the oral cavity and more so in the gingiva. According to Hirai et al (4), only eight cases of BSCC in the gingiva have been reported in the English literature (4,7–9), with only one case of BSCC occurring in the maxillary gingiva.…”

Section: Discussionmentioning

confidence: 99%

Basaloid squamous cell carcinoma of the maxillary gingiva: A case report and review of the literature

et al. 2014

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Basaloid squamous cell carcinoma (BSCC) is a rare, but distinct histologic variant of squamous cell carcinoma in the head and neck region. It is considered to have a poor prognosis due to its aggressive behavior and tendency to metastasize. The usual sites of BSCC are the floor of the mouth, hypopharynx and base of the tongue, and according to the English-language literature its presentation in the gingiva is somewhat uncommon. In the current report, the unusual case of a 40-year-old male is presented; the patient exhibited a painless irregular mass in the maxillary gingiva, which infiltrated the maxillary sinus, as observed by computed tomography. Hematoxylin and eosin-stained sections revealed a diagnosis of BSCC with typical central necrosis in the cancer nests, which contained basaloid and squamous cells. Immunohistochemistry revealed that p63 was weakly positive, high molecular weight cytokeratin (CK) was focally positive, and S-100, CK7, CK14 and vimentin were negative. It must be noted that histopathology results may be incorrectly interpreted as adenoid cystic carcinoma, undifferentiated carcinoma and basal cell adenocarcinoma.

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Basaloid squamous cell carcinoma of the maxilla

Cited by 23 publications

References 25 publications

Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature

Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature

Clinicopathologic study on a rare variant of ameloblastoma with basal cell features

Basaloid squamous cell carcinoma of the maxillary gingiva: A case report and review of the literature

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