Wedenberg C, Lindskog S. Experimental internal resorption iti monkey teelh. Endod Dctit Traumatol 1985; 1: 221-227.Abstract -Internal resorption is a rare pathological finding except in pulpeetomized deciduous teeth. Although its etiology is largely unknown, infection and trauma have been suggested in a tiutnber of eases. The aim of this study was to explore the possibility of provoking internal resorption in vivo, to study etiologieal factors sueh as trauma and infection, and to describe the cells colonizing the walls of the pulp ehamber. Monkey itieisors were opened, injected with Freund's complete adjuvant and sealed or left open to the oral cavity. After vai-ying observation periods, the teeth were extracted and ]Drepared for examination with seanning electron tnicroscopy, tnicroradiography, light microscopy and ctizytne histochemistry. Colonization of the walls of the ]3ulp chamber by macrophage-like cells was observed iti both experitnctital groups. However, it appeared to be transient in the sealed, non-infected teeth and tiiore extensive atid ptolotiged iti the open, infected teeth. In sections of pulp tissue a tartrateresistant acid phosphatase activity characteristic of mineralized tissue resorbing cells was evident. It is suggested that internal resorption may be divided into a transient type and a ]3rogressive type, the latter requiring a contitiuous stitnulatioti by itifectioti.
– The ability of stimulated and unstimulated peritoneal macrophages to spread in vitro on different inorganic and organic components of dental tissues was studied in order to establish morphologic evidence in favor of a resorption inhibitor in dentin. Macrophages were seeded onto enamel, dentin, predentin, demineralized dentin and collagen‐coated coverslips and examined with scanning electron microscopy after varying incubation periods. The cells readily attached and spread on enamel, dentin and collagen‐coated coverslips. Cells attached but showed no signs of spreading when incubated on predentin or demineralized dentin. It was concluded that the resistance to resorption of predentin and dentin rests in the organic, non‐collagenous component of the tissue, indicating the presence of a resorption inhibitor in dentin.
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