Basal-Cell Epithelioma Metastasizing to Lymph Nodes

Binkley, George W.

doi:10.1001/archderm.1962.01590090074017

Cited by 54 publications

(8 citation statements)

References 9 publications

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“…A metastatic basal cell carcinoma has been reported in a black woman, but this is the exceptional event. 2 The age at onset of the primary lesion varied over a wide range from 24 to 84 years with an average of 51 years. The lesions occurred on the head, except in 4 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-five cases were available for study from the files of the AFIP, submitted from civilian and military sources. They were coded under the following categories: metastatic basal cell carcinoma (20 cases), metastatic adnexal carcinoma (2), basal cell carcinoma of bone and muscle (l), mixed carcinoma of lung (l), and unclassified carcinoma (1). Follow-up of each patient was attempted, and additional information and material were studied when available.…”

Section: Methodsmentioning

confidence: 99%

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Metastatic basal cell carcinoma: A clinicopathologic study of seventeen cases

Farmer¹,

Helwig²

1980

Cancer

239

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Basal cell carcinoma is a common cutaneous neoplasm that rarely metastasizes. We studied the clinical and pathologic features of 17 patients with metastatic basal cell carcinoma as recorded in the files of the Armed Forces Institute of Pathology (AFIP). Sixteen of the patients were male, and as far as it could be determined, all were white. The most frequent site of metastasis was lung (9 cases), followed by bone (9, lymph nodes (4), liver (3), spleen (l) , and adrenal gland (1). Thirteen of the patients had metastatic lesions involving only one organ system. Mean survival time after metastasis was 1.6 years. Features of metatypical (basosquamous) basal cell carcinoma were common in the primary and recurrent tumors, and metastatic lesions generally had a metatypical or adenoid pattern. Two of the five bony metastases demonstrated shadow cells characteristic of pilomatrixoma. The metatypical pattern of a basal cell carcinoma is a feature of an aggressive lesion with the ability to metastasize. Cancer 46:748-757. 1980. N 1827, ARTHUR JACOB, an Irish surgeon, provided I the first clinical description of a basal cell carcinoma when he detailed findings of extensive rodent ulcers on the faces of 3 patients.14 Cecil Beadles 67 years later reported the first case of a metastatic rodent ulcer' in a 46-year-old man with a primary lesion on the face and metastases to a submandibular lymph node. Beadles provided for the first time a histologic description of the metastatic lesion. In 1900, Krompecher began publishing a series of papers on the detailed histologic features of basal cell carcinomas,lS which he believed were derived from the basal cells of the epidermis. Over the past three-quarters of a century, numerous case reports and reviews of the literature have been published on metastatic basal cell carcinomas. The questions generally asked have been as follows: 1. What is the incidence? 2. What are the demographic and clinical features of the patients? 3. the response to therapy? 4. What are the pathologic features? and 5. What are the conditions that allow or promote the occurrence of a metastatic lesion? We have studied 17 cases of metastatic basal cell carcinoma from the files of the AFIP. Our purpose was to find answers to all of the above except the question dealing with incidence. Since material submitted to AFIP is selected and not random, a true incidence could not be obtained. Recent reviews of the literature, however , have estimated the incidence to range from 0.028% to 0.55% depending upon the population These figures reinforce the general concept that metas-tasis from a basal cell carcinoma is a relatively rare event. Materials and Methods Twenty-five cases were available for study from the files of the AFIP, submitted from civilian and military sources. They were coded under the following categories: metastatic basal cell carcinoma (20 cases), metastatic adnexal carcinoma (2), basal cell carcinoma of bone and muscle (l), mixed carcinoma of lung (l), and unclassified carcinoma (1). Follow-up of each pati...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Metastatic basal cell carcinoma: A clinicopathologic study of seventeen cases

Farmer¹,

Helwig²

1980

Cancer

239

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“…100 Only a few cases of metastatic BCC have been reported in North American blacks. 41,93,96,[105][106][107] Preexisting conditions were present in 3 of the 4 cases, as 2 metastatic BCCs arose from long-standing venous stasis ulcers 41,93 and one developed from a gunshot wound scar of the shoulder. 96 Epidemiologic evidence suggests that persons with BCC or SCC of the skin are at elevated risk for the development of other malignancies.…”

Section: Bccmentioning

confidence: 99%

Skin cancer in skin of color

Gloster

Neal

2006

Journal of the American Academy of Dermatology

570

474

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“…[12][13][14][15][16][17] Similar to risk factors associated with other types of skin cancers, a fair complexion, Fitzpatrick skin type I and II, prior history of excessive sun exposure (i.e., childhood, occupation), degree of actinic damage, and personal or family history of skin cancer may all contribute to the development of MBCC. [18][19][20] Our two patients were Caucasian with Fitzpatrick skin type II.…”

Section: Incidencementioning

confidence: 99%