Basal cell carcinoma with monster cells

Elston, Dirk M.; Bergfeld, Wilma F.; Petroff, Nina

doi:10.1111/j.1600-0560.1993.tb01253.x

Cited by 29 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All cases evaluated by static image analysis cytometry have proven to be aneuploid 49 but paradoxically, mitoses, although present with roughly the same frequency as seen in typical nodular BCCs, are not often atypical. 48,49 As these pleomorphic monster cells impart no prognostic significance from the standpoint of enhanced biological aggressiveness, we speculate that this represents a form of senescent atypia.…”

Section: Follicular Bccmentioning

confidence: 86%

“…These are termed pleomorphic BCC or 'basal cell epithelioma with monster cells'. 48 Typically, these mis-shapen giant nuclei are either scattered individually through tumor lobules or show clustering suggesting that they are components of a similar clone ( Figure 13). All cases evaluated by static image analysis cytometry have proven to be aneuploid 49 but paradoxically, mitoses, although present with roughly the same frequency as seen in typical nodular BCCs, are not often atypical.…”

Section: Follicular Bccmentioning

confidence: 99%

“…These include, but are not restricted, to keratotic BCC, 39 infundibulocystic BCC (Figure 12), 42,43 follicular BCC, [44][45][46][47] which shows collision features with pilomatricoma, pleomorphic BCC ( Figure 13), 48,49 BCC with eccrine differentiation, [50][51][52] BCC with sebaceous differentiation, the fibroepithelioma of Pinkus (Figure 14), 53 and the BCC with myoepithelial differentiation. 54 Keratotic BCC Also known as pilar BCC as it appears to differentiate along pilosebaceous lines, the keratotic BCC manifests large basaloid tumor nests that are rounded and show central keratinization and degeneration.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Basal cell carcinoma: biology, morphology and clinical implications

2006

View full text Add to dashboard Cite

Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

show abstract

Section: Follicular Bccmentioning

confidence: 86%

Section: Follicular Bccmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Basal cell carcinoma: biology, morphology and clinical implications

2006

View full text Add to dashboard Cite

show abstract

“…Extensive ossification with only small remnant foci of typical BCC may eclipse diagnostic histology. BCC with monster cells 12 show scattered pleomorphic epithelial tumor cells within the tumor nodule rather than being within the stromal component. Mixed tumor of the skin can show ossification within the chondromyxoid stroma and may show follicular differentiation mimicking the BCC component.…”

Section: Discussionmentioning

confidence: 97%

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

Menamin

Goh

Poblet

et al. 2006

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Primary cutaneous carcinomas rarely show heterologous malignant mesenchymal differentiation. We report 11 cases of sarcomatoid basal cell carcinoma (BCC) with osteosarcomatous differentiation. The patients (7 men and 4 women) ranged in age from 61 to 92 years (median 75 y). The tumors presented as exophytic nodules (0.3 to 7 cm) on the head (n=6), upper limb (n=3), and lower limb (n=2). All lesions were completely excised. Seven patients were alive without evidence of disease (follow-up interval 5 to 24 mo) and 1 patient died of unrelated causes at 7 months without evidence of disease. On histology, the tumors were dermal in location with 2 cases showing focal subcutaneous involvement. Ten tumors were well-circumscribed and 1 tumor showed focally infiltrative edges. Ten tumors revealed conventional BCC associated with varying proportions of osteosarcomatous and undifferentiated sarcomatous stroma. Transition from neoplastic epithelial to mesenchymal cells was seen in 8 cases. One case showed a purely osteoclastic giant cell rich malignant mesenchyme, interpreted as representing early stages of osteosarcomatous transformation. Previously unreported in sarcomatoid BCC, the mesenchymal component of another two cases displayed predominant malignant giant cell tumor like areas and 1 further case disclosed areas reminiscent of telangiectatic osteosarcoma. Pancytokeratins (AE1/3 and MNF116) and smooth muscle actin stained occasional undifferentiated sarcomatous cells in 2 and 3 tumors, respectively. MNF116 and EMA were focally positive in osteosarcomatous tumor cells of 1 case. Although the follow-up interval is short, our data suggest an excellent prognosis for polypoid and exophytic sarcomatoid BCC after complete surgical resection.

show abstract

“…[4][5][6][7][8] Of particular concern are those found in Spitz and ''ancient'' nevi where immunohistochemical staining may support a diagnosis of a melanocytic process. Garcia et al 5 described 15 patients with 19 basal cell carcinomas containing monster cells and termed them ''pleomorphic''.…”

Section: Discussionmentioning

confidence: 98%

Monster Cells in Malignant Melanoma

Boyd¹,

Wu²,

Shyr³

2005

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Cells with significantly enlarged nuclei have been described in basal cell carcinomas, dermatofibromas, and pleomorphic fibromas, to name a few. These cells are typically visible using low power microscopy and have been termed "pleomorphic" or "monster cells." They have not been previously described in cutaneous melanomas. We sought to determine the prevalence of monster cells in otherwise conventional biopsies of primary cutaneous melanomas and its association with other histopathologic features of this malignancy. Ninety-nine superficial spreading melanomas, nodular melanomas, and acral lentiginous melanomas/lentigo malignas were retrospectively evaluated for the presence of monster cells, multinucleated giant cells, ulceration, inflammation, and depth of invasion (Breslow level). Thirteen cases of melanoma containing monster cells were found. A statistically significant association was noted between the presence of these cells, the histologic subtype of nodular melanoma (P = 0.0125), ulceration (P = 0.0127), the depth of invasion (P = 0.0103), and the presence of multinucleated giant cells (P = 0.0016). The finding of monster cells is not an uncommon occurrence and is seen more often in nodular melanomas.

show abstract

Basal cell carcinoma with monster cells

Cited by 29 publications

References 9 publications

Basal cell carcinoma: biology, morphology and clinical implications

Basal cell carcinoma: biology, morphology and clinical implications

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

Monster Cells in Malignant Melanoma

Contact Info

Product

Resources

About