Basal Cell Carcinoma of the Ala Nasi Arising in a Port Wine Stain Treated Using Mohs Micrographic Surgery and Local Flap Reconstruction

Basal cell carcinoma arising in port wine stains: coincidence or correlation?

“…Basal cell carcinoma (BCC) developing in port wine stains (PWS) has rarely been reported in the literature [1]. Most of those patients were treated in childhood with radiotherapy for PWS [2]. On the other hand there is an ongoing discussion on possible connections between BCC and PWS [1][2][3].…”

“…Most of those patients were treated in childhood with radiotherapy for PWS [2]. On the other hand there is an ongoing discussion on possible connections between BCC and PWS [1][2][3]. A port wine stain is a vascular anomaly which is present at birth and persists during life.…”

“…To the best of our knowledge, there are only eight described cases of BCC arising in PWS in patients without any prior therapy. All of them are single case reports from different European and Asian surgical centres and most of them have been reported in recent years [2]. Beyond prior radiation therapy (such as thorium X, Grenz ray and the topical radiotherapy), sun light exposure, Fitzpatrick skin type 1 and 2 and advanced age might also be considered as risk factors for developing BCC in PWS [3].…”

Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis

“…Port-wine stains (PWSs) are a congenital form of vascular malformation that are characterized by ectatic capillaries and postcapillary venules in the papillary and mid-reticular layers of the dermis, often occurring on the face and neck. PWSs are the most common type of vascular malformation, with a prevalence of approximately 0.3% in newborns 1 2 . Over time, the diameters of the vessels would progress, resulting in clinical condition and even a disfiguring lesion 3 .…”