The combined CO2 laser and photodynamic therapy of multiple BCC's in a facial port wine stain

Javed, Muhammad; Murison, Maxwell

doi:10.1016/j.bjps.2015.09.003

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Laser therapy with carbon dioxide (CO 2 ), pulsed dye, erbium:yttrium aluminum garnet (Er:YAG), and neodymium: yttrium aluminum garnet (Nd:YAG) has been explored for treatment of BCCs. [5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, laser therapy is yet to become a widely used treatment because the skin is either vaporized or coagulated, and there is no tissue available for immediate histopathological confirmation of clearance of tumor. Consequently, the resulting efficacy and cure rate have been variable, and thus a major barrier against further advances and more widespread use.…”

Section: Introductionmentioning

confidence: 99%

Reflectance confocal microscopy-guided laser ablation of basal cell carcinomas: initial clinical experience

et al. 2017

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Laser ablation offers a procedure for precise, fast, and minimally invasive removal of superficial and early nodular basal cell carcinomas (BCCs). However, the lack of histopathological confirmation has been a limitation toward widespread use in the clinic. A reflectance confocal microscopy (RCM) imaging-guided approach offers cellular-level histopathology-like feedback directly on the patient, which may then guide and help improve the efficacy of the ablation procedure. Following an ex vivo benchtop study (reported in our earlier papers), we performed an initial study on 44 BCCs on 21 patients in vivo, using a pulsed erbium:ytterbium aluminum garnet laser and a contrast agent (aluminum chloride). In 10 lesions on six patients, the RCM imaging-guided detection of either presence of residual tumor or complete clearance was immediately confirmed with histopathology. Additionally, 34 BCCs on 15 patients were treated with RCM imaging-guided laser ablation, with immediate confirmation for clearance of tumor (no histopathology), followed by longer-term monitoring, currently in progress, with follow-up imaging (again, no histopathology) at 3, 6, and 18 months. Thus far, the imaging resolution appears to be sufficient and consistent for monitoring efficacy of ablation in the wound, both immediately postablation and subsequently during recovery. The efficacy results appear to be promising, with observed clearance in 19 cases of 22 cases with follow-ups ranging from 6 to 21 months. An additional 12 cases with 1 to 3 months of follow-ups has shown clearance of tumor but a longer follow-up time is required to establish conclusive results. Further instrumentation development will be necessary to cover larger areas with a more automatically controlled instrument for more uniform, faster, and deeper imaging of margins.

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Section: Introductionmentioning

confidence: 99%

Reflectance confocal microscopy-guided laser ablation of basal cell carcinomas: initial clinical experience

et al. 2017

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“…It occurs in 0.3% of neonates [3]. Basal cell carcinoma is the most common type of skin cancer, and it usually affects elderly patients [4,5]. There are few well-documented risk factors for developing BCC such as sun exposure and ionizing radiation treatment [5].…”

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confidence: 99%

“…The surgery of BCC in PWS should be the treatment of choice. In some very selected cases of BCC in PWS, especially in patients with a high risk of perioperative bleeding, it is possible to use optional treatment with combined CO 2 laser and photodynamic therapy [5].…”

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confidence: 99%