Basal Cell Carcinoma of the Penis: A Case Report and Review of the Literature

Roewe, R. J.; Uhlman, Matthew A.; Bockholt, Nathan A.; Gupta, Amit

doi:10.1155/2014/173076

Cited by 10 publications

(9 citation statements)

References 6 publications

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“…Vulvar basal cell carcinoma represents 1–5% of all vulvar cancers, 115 while penile and scrotal basal cell carcinoma is even more rare, accounting for less than 0.03% of all BCCs in men 116,117 . Dermoscopy features have been described for vulvar basal cell carcinoma only, revealing fine, reddish, well‐focused arborizing or linear vessels 18,118–120 .…”

Section: Resultsmentioning

confidence: 99%

Dermoscopy of genital diseases: a review

Lacarrubba

Borghi

Verzì

et al. 2020

Acad Dermatol Venereol

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The male and female external genital regions are anatomical areas in which various types of skin disorders may occur. Although most of these conditions can be diagnosed by means of clinical examination and an accurate medical history, in most cases further investigations with time-consuming and/or invasive procedures are needed in order to reach the correct diagnosis. Dermoscopy, as a modern non-invasive tool, is able to better diagnose pigmented and non-pigmented skin tumours along with various inflammatory and infectious skin and appendage disorders. The aim of this paper was to provide a review of the use of dermoscopy in genital disorders based on published data and to include personal experience gained from real life, focusing on any possible gender difference and whether disease mucosal/ semimucosal dermoscopy features may differ from those observed on the skin. In conclusion, genital dermoscopy should always be considered during clinical inspection in order to enhance the diagnosis or to rule out those conditions that may look similar but that show a different dermoscopy pattern, thus narrowing down the differential diagnoses and avoiding unnecessary invasive investigations.

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Section: Resultsmentioning

confidence: 99%

Dermoscopy of genital diseases: a review

Lacarrubba

Borghi

Verzì

et al. 2020

Acad Dermatol Venereol

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“…Consistent with previous reports ( 24 ), in this cohort, most vulvar BCCs occurred on the labia majus, accounting for 89.6% of all vulvar BCC cases with known explicit location. BCCs of the penis were less frequently reported than BCCs of the scrotum ( 25 ), and in this cohort, the total number of penis BCCs accounted for only one-third of the scrotum BCCs. We found that penis BCCs showed poorer prognosis than scrotum BCC, with about 1.8 times higher risk of death.…”

Section: Discussionmentioning

confidence: 59%

Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

et al. 2021

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IntroductionBasal cell carcinoma (BCC) located on the genitalia is rare; data on the clinicopathologic features and survival outcomes are only available through case reports and small case series studies.PurposeThis study aimed to explore the epidemiology and identify the prognostic factors of genital BCCs.MethodsWe queried the 18 registries of the Surveillance, Epidemiology, and End Results database for patients with primary BCCs of the genital skin from 2000 through 2017. The primary endpoint was overall survival (OS) and disease specific survival (DSS). Kaplan-Meier survival analysis was conducted to assess the impact of clinicopathological variables on OS and DSS. Multivariate Cox proportional hazards model was performed to evaluate risk factors for OS.ResultsA total of 1,607 cases of genital BCCs were identified. The cohort was composed of 1,352 women (84.1%) and 255 men (15.9%). The median (P25, P75) age of the entire cohort was 73(63–82)years. White patients accounted for 87.2% of the cases. For women and men, the most common site of involvement was the labia majora (89.6%) and scrotum (74.5%), respectively. The majority of patients with genital BCC had localized disease (75.5%). Kaplan-Meier survival analysis showed that female genital BCCs experienced better DSS than men (209.1 months vs 194.8 months); for men, BCCs located on the scrotum had better DSS and OS than those on the penis (P < 0.05 for both endpoints). All patients with distant disease died of disease-specific death, and the average survival time was 8.2 months. Multivariate analysis revealed that age, primary site, and stage were independent determinants of OS for men, while tumor size, histologic subtype, and race were not. For women, factors associated with worse OS included increasing age, tumor size more than 2 cm, and distant disease; factors associated with a decreased risk included “other” and “unknown” races.ConclusionThe prognosis of genital BCCs is excellent, while the survival of distant disease is very poor. Despite similar clinicopathologic features and overall survival outcomes, men and women should be treated as two different entities when making survival predictions.

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“…When assessed according to the genital site, BCCs were found to occur far more frequently on the scrotum compared to other penile cancers. Previous reviews of the literature have reported that most penile BCCs occur on the penile shaft 10,11 . The number of reported cases is relatively small.…”

Section: Discussionmentioning

confidence: 99%

“…The BCCs in our study ranged from 8 × 8 mm to 11 × 13 mm in surface size. Although BCCs generally have a favorable prognosis due to minimal risk of spread, late presentations in this site may result in more extensive surgical management with associated physical and psychological morbidity 11 . Genital BCCs have significantly increased rates of metastasis compared to extragenital BCCs, accounting for 7% of all metastatic BCCs 12,13 .…”

Section: Discussionmentioning

confidence: 99%

Genital premalignant and malignant diseases: a retrospective study of male genital skin biopsies

et al. 2021

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Background Genital skin malignancies are a rare entity encountered by clinicians that may result in significant morbidity and mortality. Lack of familiarity or expertise in this area among clinicians can delay appropriate management of these conditions and may result in disease progression. Methods We performed a retrospective descriptive cohort study of male patients who received a genital skin biopsy reported by one major dermatopathology laboratory between January 2017 and December 2018 with a histological diagnosis of a premalignant or malignant condition. Patient age, type of clinician, clinical notes, genital site, type of biopsy performed, and histopathological diagnosis were evaluated. Results Of the 1525 male genital skin biopsies available for analysis, 5% (74/1525) were premalignant or malignant diseases. These included penile intraepithelial neoplasia (PeIN) (42/74, 57%), followed by invasive squamous cell carcinoma (SCC) (11/74, 15%), Bowenoid papulosis (BP) (9/74, 12%), basal cell carcinoma (8/74, 11%), malignant melanoma (2/74, 2.7%), extramammary Paget’s (1/74, 1.4%), and metastatic cutaneous deposits (1/74, 1.4%). PeIN and BP most commonly affected the penile shaft ([18/42] 43% and [4/9] 44%, respectively), invasive SCCs most commonly affected the glans penis (4/11, 36%), and all BCCs (8/8, 100%) were located on the scrotum. Invasive SCCs were most biopsied by urologists, BP was most biopsied by dermatologists, and PeINs and BCCs were most biopsied by general practitioners. Conclusions A variety of genital malignancy types were found in males. A greater understanding of male genital premalignant and malignant conditions may help guide education and further research in this area.

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Basal Cell Carcinoma of the Penis: A Case Report and Review of the Literature

Cited by 10 publications

References 6 publications

Dermoscopy of genital diseases: a review

Dermoscopy of genital diseases: a review

Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

Genital premalignant and malignant diseases: a retrospective study of male genital skin biopsies

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