Basal cell carcinoma of the head region: therapeutical results of 350 lesions treated with Mohs micrographic surgery

Veronese, Federica; Farinelli, Pamela; Zavattaro, Elisa; Zuccoli, Riccardo; Bonvini, Daniele; Leigheb, Giorgio; Colombo, Enrico

doi:10.1111/j.1468-3083.2011.04165.x

Cited by 35 publications

(36 citation statements)

References 22 publications

(45 reference statements)

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“…La edad media de nuestros pacientes fue de 68 años, con un rango comprendido entre 33 y 90 años. Veronese y colaboradores, en su experiencia de 14 años de CMM en CBC de cabeza, reportan una media de edad de 65 años con un rango de 30 a 91 (12) . Macfarlane y colaboradores reportan una media de 69 años con un rango entre 22 y 92 años (13) .…”

Section: Discussionunclassified

Cirugía micrográfica de Mohs en Uruguay: primeros 130 casos en carcinomas cutáneos

Magliano

Navarrete

Martı́nez

et al. 2018

RMU

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ResumenIntroducción: la cirugía micrográfica de Mohs es una técnica para la exéresis de cánceres de piel con el examen histológico del 100% de los márgenes quirúrgicos, logrando la tasa de curación más alta con máxima preservación de tejido sano.Objetivo: realizar una descripción clínico-epidemiológica de nuestras primeras 130 cirugías en el Hospital de Clínicas. Método: análisis descriptivo de todos los pacientes operados por un único cirujano de Mohs en nuestra Unidad de CirugíaDermatológica desde noviembre de 2013 hasta junio de 2016. Se registraron datos clínicos, tumorales y quirúrgicos.Resultados: se estudiaron 130 cirugías en 90 pacientes; 62,3% fueron realizadas en hombres y 37,7% en mujeres. La edad media fue de 68 años (rango: 33-90 años). El 67,7% provenía de Montevideo y el 32,3% del interior del país. El 68% correspondía a carcinoma basocelular y 32% a carcinoma espinocelular. El 91,5% eran tumores primarios y el 8,5% recurrentes. El 75,3% se encontraba en cabeza y cuello. El tipo más frecuente de cierre fueron los colgajos en 43% (56). Hasta el momento, 70 pacientes han completado seguimiento de al menos un año, donde se vio recidiva tumoral en un solo caso (1/70; 1,43%).Conclusiones: la cirugía de Mohs es un procedimiento seguro y eficaz, y nuestros resultados coinciden con lo descrito en centros de referencia internacional. Este es el primer centro de Uruguay que cuenta con un cirujano de Mohs y presentamos el primer estudio en pacientes uruguayos.

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Section: Discussionunclassified

Cirugía micrográfica de Mohs en Uruguay: primeros 130 casos en carcinomas cutáneos

Magliano

Navarrete

Martı́nez

et al. 2018

RMU

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“…51 The recurrence rate for MMS is estimated at between 1–3% for primary BCCs and 5–7% for recurrent BCCs. This compares favorably to reported rates for treatment with surgical excision, which are estimated at 3–10% in primary BCC and >17% in recurrent BCCs.…”

Section: Discussionmentioning

confidence: 99%

Needs Assessment for Mohs Micrographic Surgery

Asgari

Olson

Alam

2012

Dermatologic Clinics

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“…In 85% cases the metastasis occurs from the primary tumor situated in the head and neck (face) region and is infrequent from BCC over back and extremities [3]. Naso-cheek, paranasal and retroauricular folds, and inner canthus are considered to be critical sites, but there is no consensus as to whether any one histologic variety (basosquamous, micronodular, infiltrative, or morphea BCC) of the primary tumor has any predisposition for high rate of recurrence/metastasis [6, 8]. The incidence of metastasis is 2% for tumors larger than 3 cm in diameter; it increases to 25% for tumors larger than 5 cm in diameter and 50% for tumors larger than 10 cm in diameter [9].…”

Section: Discussionmentioning

confidence: 99%

“…The recurrence rate following surgical excision varies between 5% for complete excision and 30% for excisions with positive margins [14]. Mohs' micrographic surgery is the treatment of choice for histopathologically aggressive BCC subtypes owing to low recurrence rate, it has shown [8]. Several chemotherapeutic agents including 5-FU, cis platin, vincristine, etoposide, bleomycin, cyclophosphamide, methotrexate, and doxorubicin have been used alone or in combination [15–17].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma?

Mehta

Mahajan

Chauhan

et al. 2012

Case Reports in Dermatological Medicine

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Basal cell carcinoma (BCC) accounts for 80% of all nonmelanoma skin cancers. Its metastasis is extremely rare, ranging between 0.0028 and 0.55 of all BCC cases. The usual metastasis to lymph nodes, lungs, bones, or skin is from the primary tumor situated in the head and neck region in nearly 85% cases. A 69-year-old male developed progressively increasing multiple, fleshy, indurated, and at places pigmented noduloulcerative plaques over back, chest, and left axillary area 4 years after wide surgical excision of a pathologically diagnosed basal cell carcinoma. The recurrence was diagnosed as infiltrative BCC and found metastasizing to skin, soft tissue and muscles, and pretracheal and axillary lymph nodes. Three cycles of chemotherapy comprising intravenous cisplatin (50 mg) and 5-florouracil (5-FU, 750 mg) on 2 consecutive days and repeated at every 21 days were effective. As it remains unclear whether metastatic BCC is itself a separate subset of basal cell carcinoma, we feel that early BCC localized at any site perhaps constitutes a biological continuum that may ultimately manifest with metastasis in some individuals and should be evaluated as such. Long-standing BCC is itself potentially at risk of recurrence/dissemination; it is imperative to diagnose and appropriately treat all BCC lesions at the earliest.

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Basal cell carcinoma of the head region: therapeutical results of 350 lesions treated with Mohs micrographic surgery

Abstract: Low recurrence rate can be achieved when treated with MMS; it is the treatment of choice for many BCC of the head. Aggressive histopathological subtypes, critical head sites and recurrence after incomplete excision are the most important indications for MMS.

Cited by 35 publications

References 22 publications

Cirugía micrográfica de Mohs en Uruguay: primeros 130 casos en carcinomas cutáneos

Cirugía micrográfica de Mohs en Uruguay: primeros 130 casos en carcinomas cutáneos

Needs Assessment for Mohs Micrographic Surgery

Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma?

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