Basal cell carcinoma in seborrheic keratosis

Mikhail, George R.; Mehregan, Amir H.

doi:10.1016/s0190-9622(82)70042-8

Cited by 59 publications

(53 citation statements)

References 3 publications

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“…The aggregation of basalioma cells can increase the light scattering in these types of malignant lesions. The progression of seborrheic keratosis into basal cell carcinoma and squamous cell carcinoma is rare [45,46]. However, SKs can clinically resemble SCCs, and for this reason SKs are commonly removed or biopsied for histopathologic examination [47].…”

Section: Resultsmentioning

confidence: 99%

In Vivo Diagnosis of Melanoma and Nonmelanoma Skin Cancer Using Oblique Incidence Diffuse Reflectance Spectrometry

et al. 2012

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Early detection and treatment of skin cancer can significantly improve patient outcome. However, present standards for diagnosis require biopsy and histopathologic examinations that is relatively invasive, expensive and difficult for patients with many early stage lesions. Here we show an oblique incidence diffuse reflectance spectroscopic (OIDRS) system that can be used for rapid skin cancer detection in vivo. This system was tested under clinical conditions by obtaining spectra from pigmented and non-pigmented skin lesions, including melanomas, differently staged dysplastic nevi and common nevi that were validated by standard patho-histological criteria. For diagnosis of pigmented melanoma, the data obtained achieved 90% sensitivity and specificity for a blinded test set. In a second analysis, we demonstrated that this spectroscopy system can also differentiate non-pigmented basal cell or squamous cell carcinomas from non-cancerous skin abnormalities such as actinic keratoses and seborrheic keratoses, achieving 92% sensitivity and specificity. Taken together, our findings establish how oblique incidence diffuse reflectance spectrometry can be used to more rapidly and easily diagnose skin cancer in an accurate and automated manner in the clinic.

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Section: Resultsmentioning

confidence: 99%

In Vivo Diagnosis of Melanoma and Nonmelanoma Skin Cancer Using Oblique Incidence Diffuse Reflectance Spectrometry

et al. 2012

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“…Some researchers have expressed doubt about malignant transformation of seborrheic keratosis, and suggested that coexistences of seborrheic keratosis and malignant tumors were only a coincidence, an infringement of a malignant tumor onto seborrheic keratosis, a pseudoepitheliomatous hyperplasia, or irritated seborrheic keratosis (9). On the other hand, several researchers have insisted that malignant tumors that can arise in seborrheic keratosis include basal cell carcinoma (3)(4)(5), squamous cell carcinoma (8), Bowen's disease and in situ carcinoma (6,7,10), keratoacanthoma (11), and malignant melanoma (12). However, the development of a secondary malignant tumor is very rare.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor is thought to derive from normal epidermis (1) or hair follicule epithelium (2), and is not considered to present any risk of malignancy. However, a few cases with epidermal malignant transformation such as basal cell carcinoma (3)(4)(5), Bowen's disease (6,7) and squamous cell carcinoma (8) have been reported. To the best of our knowledge, transformation from seborrheic keratosis into a sweat duct tumor has not been reported.…”

Section: Introductionmentioning

confidence: 99%

A Possible Case of Eccrine Poroma Arising in Seborrheic Keratosis with Partial Intermediate Malignancy and Tumor of the Follicular Infundibulum

Akasaka

Kon

1997

The Journal of Dermatology

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An eighty-year-old woman presented with a eccrine poroma that appeared to have arisen in a seborrheic keratosis lesion on the right side of her abdomen. The tumor consisted of a brownish, flat, elevated lesion with an eroded nodule at its periphery. Histopathological analysis of the flat, elevated lesion revealed benign basaloid and squamoid cells that showed acanthotic upward proliferation, suggesting a seborrheic keratosis. The eroded nodule showed irregular proliferation of slight atypical squamoid cells with, in parts, ductal structures in the upper dermis, suggesting that it was an eccrine poroma with partial intermediate malignancy. In addition to the eroded nodule, an occult tumor clinically accompanied the seborrheic keratosis. Histopathology of the occult tumor revealed fenestrated columns and cords of pale epithelial cells attached to the base of the seborrheic keratosis lesion, which was diagnosed as a tumor of the follicular infundibulum. Although reports of seborrheic keratosis transforming into a sweat gland tumor are rare, the present case suggests that seborrheic keratosis may develop into benign or malignant adnexal tumors, including sweat gland and follicular tumors. Thus, seborrheic keratosis should be considered as a possible precursor of adnexal tumor.

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“…Malignant changes with seborrhoeic keratosis, represented by basal cell carcinomas and squamous cell carcinomas, have been documented in humans. 7 Because this tumor occurred in only one dog and there is little clinical data in the previous report, no conclusions concerning age, breed, sex, or site predilections can be made. The dog was in good health 2.5 years after tumor excision, and there was no evidence of local regrowth or metastasis.…”

mentioning

confidence: 92%

Immunohistopathologic Characterization of a Dermal Melanocytoma-Acanthoma in a German Shepherd Dog

Monteros¹,

Mulas²,

Fernández³

et al. 2000

Vet Pathol

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Abstract.A cutaneous melanocytoma-acanthoma in a 2-year-old female German Shepherd Dog was characterized by the presence of two populations of neoplastic cells: epithelial and melanocytic. The epithelial component consisted of nests of well-differentiated stratified squamous epithelium closely associated with neoplastic melanocytes. The epithelial cells immunoreacted with both monoclonal and polyclonal anti-cytokeratin antibodies, and immunoreaction to S-100 protein and vimentin was observed in the melanocytic cells. This rare pigmented skin neoplasm of the dog apparently has a benign behavior.

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Basal cell carcinoma in seborrheic keratosis

Cited by 59 publications

References 3 publications

In Vivo Diagnosis of Melanoma and Nonmelanoma Skin Cancer Using Oblique Incidence Diffuse Reflectance Spectrometry

In Vivo Diagnosis of Melanoma and Nonmelanoma Skin Cancer Using Oblique Incidence Diffuse Reflectance Spectrometry

A Possible Case of Eccrine Poroma Arising in Seborrheic Keratosis with Partial Intermediate Malignancy and Tumor of the Follicular Infundibulum

Immunohistopathologic Characterization of a Dermal Melanocytoma-Acanthoma in a German Shepherd Dog

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