Immunohistopathologic Characterization of a Dermal Melanocytoma-Acanthoma in a German Shepherd Dog

Abstract

Abstract.A cutaneous melanocytoma-acanthoma in a 2-year-old female German Shepherd Dog was characterized by the presence of two populations of neoplastic cells: epithelial and melanocytic. The epithelial component consisted of nests of well-differentiated stratified squamous epithelium closely associated with neoplastic melanocytes. The epithelial cells immunoreacted with both monoclonal and polyclonal anti-cytokeratin antibodies, and immunoreaction to S-100 protein and vimentin was observed in the melanocytic cells. This rare pigmented skin neoplasm of the dog apparently has a benign behavior.

Collision Tumour of Squamous Cell Carcinoma and Malignant Melanoma in the Oral Cavity of a Dog

“…The degree of pigmentation and the microscopical appearance of oral melanomas make it necessary to include in the differential diagnosis carcinomas, soft tissue sarcomas, round cell neoplasms and osteogenic tumors (Ramos-Vara et al, 2000). S100 protein, melan A, NSE and vimentin are widely used as melanocytic markers in the diagnosis of canine melanomas (Espinosa de los Monteros et al, 2000;Ramos-Vara et al, 2000;Head et al, 2002), and were detected in the present case. The location of the SCC is in agreement with reports that indicate that maxilary SCC is twice as common as SCC of mandibular origin (Todoroff and Brodey, 1979).…”

“…The term 'collision tumour' indicates two co-existent, but independent, neoplasms with distinct morphology that may be adjacent to each other or intermingled (Pool et al, 1999;Head et al, 2002). A benign dermal melanocytomaeacanthoma, composed of two different mature cell populations, epithelial and melanocytic, was described in a German shepherd dog (Espinosa de los Monteros et al, 2000).…”

Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review

“…An investigation by the Publisher found it to be one of a group of articles we have identified as showing evidence suggestive of attempts to subvert the peer review and publication system to inappropriately obtain or allocate authorship. This article showed evidence of plagiarism (most notably from the articles cited [2–5]) and authorship manipulation.…”

Oral Malignant Squamo-Melanocytic Tumor in a Dog

“…The term melanoacanthoma has been used to describe a simultaneous benign mixed tumor of keratinocytes and the pigment-laden dendritic melanocytes. 6,7 Like cutaneous melanoacanthoma, oral melanoacanthoma demonstrates hyperplasia of spinous keratinocytes and melanocytes, but unrelated to seborrheic keratosis. [21][22][23] In the veterinary literature, melanoacanthoma has been infrequently described only on the skin of dogs as melanocytoma-acanthoma.…”

“…[1][2][3][4] There is no apparent breed predilection for oral squamous cell carcinoma, however Cocker Spaniels have an increased risk for oral melanoma. 6,7 A case of an unusual malignant oral neoplasm from a 10.5year-old spayed/female Cocker Spaniel dog with a combination of both malignant melanoma and squamous cell carcinoma is reported here. 2,3,5 Only two case reports in the veterinary literature have described a cutaneous benign tumor with features of both melanoma and acanthoma.…”