Basal cell carcinoma after radiation therapy in breast cancer

Marques-Antunes, Joana; Braga, José Wilson Ramos; Santos, Teresa; Nora, Mário; Scigliano, Horácio

doi:10.1111/tbj.14266

Cited by 1 publication

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“…Another study confirmed the association between chemotherapy in breast cancer patients and an elevated risk of leukemia (Cole and Strair, 2010). Additionally, a study reported a case of basal cell carcinoma following radiotherapy for breast cancer in 2021 (Marques-Antunes et al, 2021). Moreover, the associations between breast cancer and pulmonary sarcoidosis, ischemic diseases, spinal cord injuries, Ewing's sarcoma and Lymphoma have been validated in the literature (Dong et al, 2021;Sawatzky et al, 2021;Altshuler et al, 2023).…”

Section: Case Studies Of Mirna Set Enrichment Analysismentioning

confidence: 72%

MHIF-MSEA: a novel model of miRNA set enrichment analysis based on multi-source heterogeneous information fusion

Li,

Ma,

Lin

et al. 2024

Front. Genet.

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Introduction: MicroRNAs (miRNAs) are a class of non-coding RNA molecules that play a crucial role in the regulation of diverse biological processes across various organisms. Despite not encoding proteins, miRNAs have been found to have significant implications in the onset and progression of complex human diseases.Methods: Conventional methods for miRNA functional enrichment analysis have certain limitations, and we proposed a novel method called MiRNA Set Enrichment Analysis based on Multi-source Heterogeneous Information Fusion (MHIF-MSEA). Three miRNA similarity networks (miRSN-DA, miRSN-GOA, and miRSN-PPI) were constructed in MHIF-MSEA. These networks were built based on miRNA-disease association, gene ontology (GO) annotation of target genes, and protein-protein interaction of target genes, respectively. These miRNA similarity networks were fused into a single similarity network with the averaging method. This fused network served as the input for the random walk with restart algorithm, which expanded the original miRNA list. Finally, MHIF-MSEA performed enrichment analysis on the expanded list.Results and Discussion: To determine the optimal network fusion approach, three case studies were introduced: colon cancer, breast cancer, and hepatocellular carcinoma. The experimental results revealed that the miRNA-miRNA association network constructed using miRSN-DA and miRSN-GOA exhibited superior performance as the input network. Furthermore, the MHIF-MSEA model performed enrichment analysis on differentially expressed miRNAs in breast cancer and hepatocellular carcinoma. The achieved p-values were 2.17e(-75) and 1.50e(-77), and the hit rates improved by 39.01% and 44.68% compared to traditional enrichment analysis methods, respectively. These results confirm that the MHIF-MSEA method enhances the identification of enriched miRNA sets by leveraging multiple sources of heterogeneous information, leading to improved insights into the functional implications of miRNAs in complex diseases.

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