Bartter's syndrome and diabetes mellitus

Raman, Gowri; Albano, J. D. M.; Millar, Jane; Lee, H. A.

doi:10.1111/j.1365-2796.1990.tb00273.x

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…Example of drugs used for treating comorbid conditions like hypertension in diabetes are thiazide or loop diuretics, Angiotensin Converting Enzyme Inhibitors (ACEIs) and Angiotensin 2 Receptor Blockers (ARBs) which may also result in EI. Furthermore insulin secretion is decreased in hypokalemia 7,8 , and K+ infusions improve glucose tolerance by increasing insulin and proinsulin concentrations 9 .…”

mentioning

confidence: 99%

Electrolyte Imbalance in Admitted Diabetic Patients: Patterns and Factors Responsible- A Cross Sectional Study

Ahmed

Nur²,

Ullah

et al. 2017

KYAMC j.

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Diabetes Mellitus (DM) is a major burden upon health-care facilities in all countries. Electrolyte imbalances (EI) are very common in admitted patients with diabetes which leads to substantial morbidity and mortality. Every patient with diabetes needs thorough evaluation for the etiology and precipitating factors responsible for EI and therefore rational management. Data regarding the incidence of EI in DM in our country is limited. There is no existing record for profiling of EI in Bangladeshi diabetic subjects. The objective of this study was to find out the common types of EI in hospitalized diabetic patients and to determine the influencing factors responsible for them. Samples were selected from all adult nonpregnant diabetic patients admitted in the indoor, department of Medicine with electrolyte disturbances irrespective of their cause of admission. A total number of 150 admitted diabetic patients with electrolyte imbalance were interviewed, examined physically and laboratory specimen taken for biochemical analysis. Information was collected in a semi structured data collection form for analysis. Hyponatremia was found to be the most common EI in admitted diabetic patients. Electrolyte imbalance was found to be more common in the aged and female populations. Common factors influencing EI were vomiting, diarrhea, sweating, uncontrolled diabetes with severe hyperglycemia and certain drugs especially diuretics. Among the other well established complications of diabetes like acute metabolic complications, microangiopathy and macroangiopathy, EI should also be considered especially in the admitted patients.KYAMC Journal Vol. 5, No.-1, Jul 2014, Page 458-466

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confidence: 99%

Electrolyte Imbalance in Admitted Diabetic Patients: Patterns and Factors Responsible- A Cross Sectional Study

Ahmed

Nur²,

Ullah

et al. 2017

KYAMC j.

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“…The potential causal relationship between BS and type 2 diabetes mellitus remains uncertain 18. Venkat et al 19 reported that patients with BS displayed elevated insulin concentrations and hyperplasia of the islets of Langerhans was noted during autopsies and also described worsened glycaemic control following a late-onset BS diagnosis. However, it is worth noting that hypokalaemia can lead to decreased insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

Bartter syndrome-like phenotype in a patient with type 2 diabetes mellitus

Kumar,

Shreshta,

Samdarshi

et al. 2024

BMJ Case Rep

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Bartter syndrome (BS) is a rare genetic tubulopathy affecting the loop of Henle leading to salt wasting. It is commonly seen in utero or in the early neonatal period. Rare cases of acquired BS are reported in association with infections like tuberculosis, granulomatous conditions like sarcoidosis, autoimmune diseases and drugs. The mainstay of management includes potassium, calcium and magnesium supplementation. We report the case of a woman in her 50s with a history of type 2 diabetes mellitus for the last 10 years, who presented with diabetic foot ulcers and generalised weakness with ECG changes suggestive of hypokalaemia. She had severe hypokalaemia with high urine potassium excretion and hypochloraemic metabolic alkalosis. She poorly responded to intravenously administered potassium supplements and had persistent hypokalaemia. On further evaluation of the persistent hypokalaemia, a diagnosis of idiopathic Bartter-like phenotype was made. She responded well to tablet indomethacin and is presently asymptomatic and is being maintained on tablet indomethacin after 6 months of follow-up.

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“…In the literature a few case reports describe idiopathic BS-like phenotype in association with type 2 diabetes. Venkat et al described patients with BS who displayed elevated insulin concentrations, with hyperplasia of the islets of Langerhans noted at autopsy [ 18 ]. Worsening of glycemic control following a diagnosis of late onset BS was described in another case report [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Bartter syndrome-like phenotype in a patient with diabetes: a case report

2018

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BackgroundBartter’s syndrome is a rare genetic tubulopathy affecting the loop of Henle leading to salt wasting. It is commonly seen in utero or in early neonatal period. Rare cases of acquired Bartter’s syndrome are reported in association with infections like tuberculosis, granulomatous conditions like sarcoidosis, autoimmune diseases, and drugs. The mainstay of management includes potassium, calcium, and magnesium supplementation.Case presentationWe report the case of a 62-year-old Sri Lankan Sinhalese man with diabetes and hypertension presenting with generalized weakness with clinical evidence of proximal myopathy. He was severely hypokalemic with high urinary potassium excretion and hypochloremic metabolic alkalosis. He poorly responded to intravenously administered potassium supplements. A diagnosis of idiopathic Bartter-like phenotype was made. He responded well to spironolactone and indomethacin.ConclusionsPatients presenting with body weakness need serum potassium estimation. Acquired Bartter’s syndrome although rare, should be ruled out in those with hypokalemia and metabolic alkalosis with increased urinary potassium loss with poor response to potassium replacement.

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Bartter's syndrome and diabetes mellitus

Cited by 8 publications

References 22 publications

Electrolyte Imbalance in Admitted Diabetic Patients: Patterns and Factors Responsible- A Cross Sectional Study

Electrolyte Imbalance in Admitted Diabetic Patients: Patterns and Factors Responsible- A Cross Sectional Study

Bartter syndrome-like phenotype in a patient with type 2 diabetes mellitus

Bartter syndrome-like phenotype in a patient with diabetes: a case report

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