Bartonella spp. bacteremia in high-risk immunocompetent patients

Maggi, Ricardo G.; Mascarelli, Patricia E.; Pultorak, Elizabeth L.; Hegarty, Barbara C.; Bradley, Julie M.; Mozayeni, B. Robert; Breitschwerdt, Edward B.

doi:10.1016/j.diagmicrobio.2011.09.001

Cited by 83 publications

(157 citation statements)

References 53 publications

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“…bacteremia had been confirmed by enrichment PCR 1. In people and dogs with B. henselae bacteremia, poor correlation between IFA seroreactivity and PCR has been documented 19. Investigating the presence of bacteremia with BAPGM blood enrichment culture techniques, as described by Duncan et al, also could have been considered 20…”

mentioning

confidence: 99%

Identification of Bartonella henselae in the Liver of a Thoroughbred Foal with Severe Suppurative Cholangiohepatitis

Setlakwe

Sweeney

Engiles

et al. 2014

Veterinary Internal Medicne

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mentioning

confidence: 99%

Identification of Bartonella henselae in the Liver of a Thoroughbred Foal with Severe Suppurative Cholangiohepatitis

Setlakwe

Sweeney

Engiles

et al. 2014

Veterinary Internal Medicne

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“…At least 17 Bartonella species have been associated with an expanding spectrum of human diseases, ranging from acute self-limiting illness to more severe disease manifestations, including encephalopathy, endocarditis, neurologic dysfunction, pleural and pericardial effusion, pneumonia, and hemolytic anemia (2,(5)(6)(7)(8). To enhance the diagnostic documentation of infection with Bartonella spp., our laboratory has combined enrichment cultures that utilize an insect cell culture liquid growth medium, Bartonella Alphaproteobacteria growth medium (BAPGM), with highly sensitive PCR assays (7,9). When used to test blood, cerebrospinal and joint fluids, or pathological effusions from dogs or horses, PCR following enrichment culture has enhanced the diagnostic sensitivity over blood PCR testing alone (10)(11)(12)(13).…”

mentioning

confidence: 99%

Serial Testing from a 3-Day Collection Period by Use of the Bartonella Alphaproteobacteria Growth Medium Platform May Enhance the Sensitivity of Bartonella Species Detection in Bacteremic Human Patients

et al. 2013

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Patients with infection from bacteremic Bartonella spp., tested using Bartonella Alphaproteobacteria growth medium (BAPGM), were retrospectively categorized into one of two groups that included those whose blood was collected once (group 1; n ‫؍‬ 55) or three times (group 2; n ‫؍‬ 36) within a 1-week period. Overall, 19 patients (20.8%) were PCR positive for one or more Bartonella spp. using the BAPGM platform. Seven patients (12.7%) in group 1 tested positive, and 12 patients (33.3%) in group 2 tested positive. Detection was improved when the patients were tested three times within a 1-week period (odds ratio, 3.4 [95% confidence interval, 1.2 to 9.8]; P ‫؍‬ 0.02). Obtaining three sequential blood samples during a 1-week period should be considered a diagnostic approach when bartonellosis is suspected.

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“…Rather than being confined to CSD, it is apparent that human and canine bartonellosis encompass pathological syndromes of vasoproliferative pathology, granulomatous inflammation, and endocarditis [59] associated with long incubation times, persistent infections, and arthropod transmission [59]. Animal contact, and therefore contact with their ectoparasites, puts certain individuals at risk of contracting Bartonella-associated disease, which may remain undiagnosed for many years [59,60].…”

Section: Paradigm 3: Fleas Are More Than Simply a Nuisancementioning

confidence: 99%

“…Through their occupation, veterinary professionals (veterinary surgeons, veterinary nurses, and technicians) and animal carers (animal welfare workers, rangers, shelter staff, etc.) are in contact with a wide range of companion, production, and wild animal species and, by extension, are frequently exposed to arthropod vectors such as ticks, fleas, and lice that infest these animals ( Figure 3) [60].…”

Section: Paradigm 4: Cvbd Veterinarians and Public Healthmentioning

confidence: 99%

“…Indeed, the same study found that small animal practitioners were three times less likely than their large animal colleagues to use adequate personal protective equipment (PPE) [61]. In the USA, Bartonella seroreactivity and bacteraemia were documented in approximately one half (49.5%) and a quarter (23.9%) of the individuals, respectively, of persons (n=192) who reported animal exposure, most of whom also reported animal scratches and/or bites [60].…”

Section: Paradigm 4: Cvbd Veterinarians and Public Healthmentioning

confidence: 99%

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It shouldn’t happen to a dog … or a veterinarian: clinical paradigms for canine vector-borne diseases

Irwin

2014

Trends in Parasitology

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Keywords:Canine, vector-borne diseases, zoonosis, emerging disease, diagnosis, travel medicine, compliance AbstractCanine vector-borne diseases (CVBDs) comprise a diverse group of viral, bacterial, protozoal, and helminth pathogens, transmitted predominantly by ticks and fleas, and cause significant health problems for dogs worldwide. Growing numbers of reports indicate that CVBDs are emerging in regions where they previously did not exist and this, combined with pathogens that are inherently difficult to detect, is providing companion animal veterinarians with some significant diagnostic challenges. This review discusses six paradigms concerning the diagnosis, treatment, prevention, and zoonotic implications of CVBDs from a veterinary clinical perspective. Veterinarians are the key professionals at the companion animal: human interface. Not only do they provide the traditional medical and surgical services for pets, their training in the disciplines of parasitology, microbiology, epidemiology, and public health place them in a unique position to provide advice about matters pertaining to vector-borne diseases. Despite this, emerging canine vector-borne diseases (CVBDs) pose a number of significant and complex challenges for veterinarians in clinical practice whose responsibility it is to diagnose and treat these companion animals, while at the same time remaining mindful of the potential for disease transmission to the owners and other people living in close proximity, as well as to other susceptible animals [5]. As will be discussed here, many CVBDs are caused by organisms that are inherently difficult to detect, frequently cause nebulous clinical signs in their canine hosts, and are sometimes zoonotic. In addition, the rapid progress of scientific research in this area itself poses further challenges of how best to distil and disseminate this knowledge to busy veterinary practitioners worldwide at a time when every aspect of clinical practice is becoming more complex. How should practitioners keep current with information in this area so that they can provide appropriate evidence-based advice to their clients?

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Bartonella spp. bacteremia in high-risk immunocompetent patients

Cited by 83 publications

References 53 publications

Identification of Bartonella henselae in the Liver of a Thoroughbred Foal with Severe Suppurative Cholangiohepatitis

Identification of Bartonella henselae in the Liver of a Thoroughbred Foal with Severe Suppurative Cholangiohepatitis

Serial Testing from a 3-Day Collection Period by Use of the Bartonella Alphaproteobacteria Growth Medium Platform May Enhance the Sensitivity of Bartonella Species Detection in Bacteremic Human Patients

It shouldn’t happen to a dog … or a veterinarian: clinical paradigms for canine vector-borne diseases

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