Bartonella bacilliformis: colonial types and erythrocyte adherence

Walker, T S; Winkler, Herbert H.

doi:10.1128/iai.31.1.480-486.1981

Cited by 42 publications

(26 citation statements)

References 11 publications

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“…Bacterial uptake must therefore be actively triggered by the pathogen. Consistently, energy depletion in bacteria impeded invasion of B. bacilliformis into erythrocytes (Walker and Winkler, ). One of likely several energy‐dependent steps in B. bacilliformis uptake into erythrocytes is the initial attachment to the erythrocyte membrane.…”

Section: Infection Of Erythrocytesmentioning

confidence: 84%

“…Indeed, a block of flagella by antibodies diminishes the association with erythrocytes (Scherer et al ., ). Non‐motile B. bacilliformis do not attach to erythrocytes at all (Walker and Winkler, ), yet flagella isolated from B. bacilliformis do not bind to erythrocytes. The role of flagella in erythrocytic adherence thus remains controversial.…”

Section: Infection Of Erythrocytesmentioning

confidence: 99%

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Bartonellaentry mechanisms into mammalian host cells

Eicher

Dehio

2012

Cellular Microbiology

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SummaryThe Gram-negative genus Bartonella comprises arthropod-borne pathogens that typically infect mammals in a host-specific manner. Bartonella bacilliformis and Bartonella quintana are humanspecific pathogens, while several zoonotic bartonellae specific for diverse animal hosts infect humans as an incidental host. Clinical manifestations of Bartonella infections range from mild symptoms to life-threatening disease. Following transmission by blood-sucking arthropods or traumatic contact with infected animals, bartonellae display sequential tropisms towards endothelial and possibly other nucleated cells and erythrocytes, the latter in a host-specific manner. Attachment to the extracellular matrix (ECM) and to nucleated cells is mediated by surface-exposed bacterial adhesins, in particular trimeric autotransporter adhesins (TAAs). The subsequent engulfment of the pathogen into a vacuolar structure follows a unique series of events whereby the pathogen avoids the endolysosomal compartments. For Bartonella henselae and assumingly most other species, the infection process is aided at different steps by Bartonella effector proteins (Beps). They are injected into host cells through the type IV secretion system (T4SS) VirB/D4 and subvert host cellular functions to favour pathogen uptake. Bacterial binding to erythrocytes is mediated by Trw, another T4SS, in a strictly hostspecific manner, followed by pathogen-forced uptake involving the IalB invasin and subsequent replication and persistence within a membranebound intra-erythrocytic compartment.

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Section: Infection Of Erythrocytesmentioning

confidence: 84%

Section: Infection Of Erythrocytesmentioning

confidence: 99%

Bartonellaentry mechanisms into mammalian host cells

Eicher

Dehio

2012

Cellular Microbiology

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“…infection in their reservoir hosts, but not in the incidental hosts, is a longlasting intraerythrocytic bacteremia. This also applies to the human-specific B. quintana (Rolain et al, 2002;Rolain et al, 2003c), a louse-transmitted bacterium that was initially detected during World War I as the causative agent of trench fever (5-day fever), and B. bacilliformis (Walker & Winkler, 1981;Benson et al, 1986), a sand fly-transmitted bacterium (Maguiña et al, 2009). Bartonella bacilliformis is so far the only known species of Bartonella spp.…”

Section: Adhesion To the Erythrocytesmentioning

confidence: 99%

Persistence ofBartonellaspp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation

2012

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Bartonella spp. are facultative intracellular bacteria that typically cause a long-lasting intraerythrocytic bacteremia in their mammalian reservoir hosts, thereby favoring transmission by blood-sucking arthropods. In most cases, natural reservoir host infections are subclinical and the relapsing intraerythrocytic bacteremia may last weeks, months, or even years. In this review, we will follow the infection cycle of Bartonella spp. in a reservoir host, which typically starts with an intradermal inoculation of bacteria that are superficially scratched into the skin from arthropod feces and terminates with the pathogen exit by the blood-sucking arthropod. The current knowledge of bacterial countermeasures against mammalian immune response will be presented for each critical step of the pathogenesis. The prevailing models of the still-enigmatic primary niche and the anatomical location where bacteria reside, persist, and are periodically seeded into the bloodstream to cause the typical relapsing Bartonella spp. bacteremia will also be critically discussed. The review will end up with a discussion of the ability of Bartonella spp., namely Bartonella henselae, Bartonella quintana, and Bartonella bacilliformis, to induce tumor-like vascular deformations in humans having compromised immune response such as in patients with AIDS.

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“…Some characterization of erythrocyte receptors and bartonella ligands has been attempted, yielding somewhat conflicting results, although there does appear to be a carbohydrate component to the receptor. 29 Molecular studies have identified two genetic loci that encode proteins that appear to have a role in erythrocyte association. The first of these loci, the ial locus, comprising two genes ialA and ialB, was identified by its ability to confer an erythrocyte-invading phenotype on E. coli cells into which it had been introduced.…”

Section: Exploitation Of Erythrocytesmentioning

confidence: 99%

Bartonellae as Elegant Hemotropic Parasites

Birtles

2005

Annals of the New York Academy of Sciences

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Bartonella species are hemotropic bacterial parasites of a wide range of mammals that occasionally cause disease in humans. The low prevalence of clinical manifestations compared to the high prevalence of infection underlines the elegance of these parasites that carefully exploit their hosts in a manner that optimizes their transmission. Recent research efforts have begun to determine the strategies involved in this exploitation, and significant progress has been made in unraveling an unusually complex natural cycle. Studies aimed at determining bacterial attributes involved in parasitism characterized several "virulence" factors and explored their modes of action. These efforts have provided an intriguing foundation on which future efforts aimed at comprehending these sophisticated parasites can be soundly based.

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Bartonella bacilliformis: colonial types and erythrocyte adherence

Cited by 42 publications

References 11 publications

Bartonellaentry mechanisms into mammalian host cells

Bartonellaentry mechanisms into mammalian host cells

Persistence ofBartonellaspp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation

Bartonellae as Elegant Hemotropic Parasites

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